Synthesis, characterization and pharmacological screening of novel benzimidazole derivatives

In present study o-phenylenediamine and phenoxyacetic acid were used as starting material through series of steps 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]acetohydrazide 5 was obtained. Various derivatives of 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]-N′-[(Z)-phenylmethylidene]acetohydrazide and so...

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Bibliographic Details
Published in:	Arabian journal of chemistry Vol. 9; no. S1; pp. S342 - S347
Main Authors:	Shaharyar, Mohammad, Mazumder, Avijit, Salahuddin, Garg, Ruchika, Pandey, Rishabh D
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-09-2016 Elsevier
Subjects:	Anticonvulsant activity Benzimidazole Pharmacological screening Anticonvulsant activity Pharmacological screening Benzimidazole
Online Access:	Get full text
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Summary:	In present study o-phenylenediamine and phenoxyacetic acid were used as starting material through series of steps 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]acetohydrazide 5 was obtained. Various derivatives of 2-[2-(phenoxymethyl)-1H-benzimidazol-1-yl]-N′-[(Z)-phenylmethylidene]acetohydrazide and some compounds containing oxadiazole bearing benzimidazole were synthesized by using various aromatic aldehyde, cyanogens bromide and carbon disulfide/potassium hydroxide. These were elucidated by IR, NMR and elemental analysis and their in vivo anticonvulsant screening was performed using MES and scPTZ. Two compounds 7g and j were found to be potent in both the screens and their protective index was found to be better than standard drugs used.
ISSN:	1878-5352 1878-5379
DOI:	10.1016/j.arabjc.2011.04.013