Search Results - "Panda, Siva S"

Natural Products as Potential Anti-Alzheimer Agents by Panda, Siva S, Jhanji, Nancy

“…Medicinal plants have curative properties due to the presence of various complex chemical substances of different composition, which are found as secondary…”
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Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold by Panda, Siva S, Girgis, Adel S, Aziz, Marian N, Bekheit, Mohamed S

“…Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising…”
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Ursolic Acid Analogs as Potential Therapeutics for Cancer by Panda, Siva S, Thangaraju, Muthusamy, Lokeshwar, Bal L

“…Ursolic acid (UA) is a pentacyclic triterpene isolated from a large variety of vegetables, fruits and many traditional medicinal plants. It is a structural…”
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DNA Gyrase as a Target for Quinolones by Spencer, Angela C, Panda, Siva S

“…Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to DNA substrates and is a clinically-relevant target for the…”
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Azomethine Ylides-Versatile Synthons for Pyrrolidinyl-Heterocyclic Compounds by Panda, Siva S, Aziz, Marian N, Stawinski, Jacek, Girgis, Adel S

“…Azomethine ylides are nitrogen-based three-atom components commonly used in [3+2]-cycloaddition reactions with various unsaturated 2π-electron components…”
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Spirooxindoles as Potential Pharmacophores by Panda, Siva S, Jones, Rachel A, Bachawala, Praveen, Mohapatra, Prabhu P

“…The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Over the past few decades,…”
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Plant-Based Natural Products and Extracts: Potential Source to Develop New Antiviral Drug Candidates by Thomas, Eyana, Stewart, Laura E, Darley, Brien A, Pham, Ashley M, Esteban, Isabella, Panda, Siva S

“…Viral infections are among the most complex medical problems and have been a major threat to the economy and global health. Several epidemics and pandemics…”
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Molecular Hybridization of Alkaloids Using 1,2,3-Triazole-Based Click Chemistry by Buchanan, Devan, Pham, Ashley M, Singh, Sandeep K, Panda, Siva S

“…Alkaloids found in multiple species, known as ‘driver species’, are more likely to be included in early-stage drug development due to their high biodiversity…”
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Indole-Based Compounds as Potential Drug Candidates for SARS-CoV-2 by Girgis, Adel S, Panda, Siva S, Kariuki, Benson M, Bekheit, Mohamed S, Barghash, Reham F, Aboshouk, Dalia R

“…The COVID-19 pandemic has posed a significant threat to society in recent times, endangering human health, life, and economic well-being. The disease quickly…”
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Modified Curcumins as Potential Drug Candidates for Breast Cancer: An Overview by Flint, Abigail L, Hansen, David W, Brown, LaVauria D, Stewart, Laura E, Ortiz, Eduardo, Panda, Siva S

“…Breast cancer (BC), the most common malignancy in women, results from significant alterations in genetic and epigenetic mechanisms that alter multiple…”
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Editorial: Advances in natural product chemistry: Yunnan University 100th anniversary by Chen, Wen, Dong, Jianwei, Panda, Siva S

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New NSAID Conjugates as Potent and Selective COX-2 Inhibitors: Synthesis, Molecular Modeling and Biological Investigation by Bokhtia, Riham M, Panda, Siva S, Girgis, Adel S, Samir, Nermin, Said, Mona F, Abdelnaser, Anwar, Nasr, Soad, Bekheit, Mohamed S, Dawood, Abdelhameed S, Sharma, Horrick, Wade, Margaret, Sharma, Swapnil K, Ghanim, Amany M

“…New sets of ibuprofen and indomethacin conjugates comprising triazolyl heterocycle were synthesized via click chemistry, adopting an optimized protocol through…”
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Synthesis, antibacterial properties and 2D-QSAR studies of quinolone-triazole conjugates by Faidallah, Hassan M., Girgis, Adel S., Tiwari, Anand D., Honkanadavar, Hitesh H., Thomas, Sean J., Samir, Ahmed, Kalmouch, Atef, Alamry, Khalid A., Khan, Khalid A., Ibrahim, Tarek S., AL-Mahmoudy, Amany M.M., Asiri, Abdullah M., Panda, Siva S.

“…A set of 1,2,3-triazole incorporated quinolone antibiotic conjugates 10–15, 17–19 were synthesized via microwave assisted click chemistry technique. Some of…”
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Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach by Wyman, Kailey A, Girgis, Adel S, Surapaneni, Pragnakiran S, Moore, Jade M, Abo Shama, Noura M, Mahmoud, Sara H, Mostafa, Ahmed, Barghash, Reham F, Juan, Zou, Dobaria, Radha D, Almalki, Ahmad J, Ibrahim, Tarek S, Panda, Siva S

“…We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates…”
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Development of spiro-3-indolin-2-one containing compounds of antiproliferative and anti-SARS-CoV-2 properties by Fawazy, Nehmedo G., Panda, Siva S., Mostafa, Ahmed, Kariuki, Benson M., Bekheit, Mohamed S., Moatasim, Yassmin, Kutkat, Omnia, Fayad, Walid, El-Manawaty, May A., Soliman, Ahmed A. F., El-Shiekh, Riham A., Srour, Aladdin M., Barghash, Reham F., Girgis, Adel S.

“…A series of 1″-(alkylsulfonyl)-dispiro[indoline-3,2′-pyrrolidine-3′,3″-piperidine]-2,4″-diones 6a‒o has been synthesized through regioselective multi-component…”
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Indole Compounds in Oncology: Therapeutic Potential and Mechanistic Insights by Hassan, Sara M, Farid, Alyaa, Panda, Siva S, Bekheit, Mohamed S, Dinkins, Holden, Fayad, Walid, Girgis, Adel S

“…Cancer remains a formidable global health challenge, with current treatment modalities such as chemotherapy, radiotherapy, surgery, and targeted therapy often…”
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Design, Synthesis, and Molecular Docking Studies of Curcumin Hybrid Conjugates as Potential Therapeutics for Breast Cancer by Panda, Siva S, Tran, Queen L, Rajpurohit, Pragya, Pillai, Girinath G, Thomas, Sean J, Bridges, Allison E, Capito, Jason E, Thangaraju, Muthusamy, Lokeshwar, Bal L

“…Curcumin (CUR) has received great attention over the past two decades due to its anticancer, anti-inflammatory, and antioxidant properties. Similarly,…”
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Novel Curcumin Inspired Antineoplastic 1-Sulfonyl-4-Piperidones: Design, Synthesis and Molecular Modeling Studies by Fawzy, Nehmedo G, Panda, Siva S, Fayad, Walid, El-Manawaty, May A, Srour, Aladdin M, Girgis, Adel S

“…Curcumin is a well-known example of plant origin exhibiting promising diverse biological properties such as, anti-inflammatory and antitumor as well as poor…”
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Microwave-Assisted Synthesis of Tri-Substituted 1,3,5-Triazines from Metformin Using Benzotriazole Chemistry by Panda, Siva S., Thomas, Eyana, Pham, Ashley M.

“…A simple, metal-free, cost-effective, and eco-friendly protocol for the preparation of trisubstituted 1,3,5 triazine from metformin using benzotriazole…”
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Editorial: Current approaches in infectious disease drug discovery by Silva-Jr, Floriano P, Panda, Siva S, Andrade, Carolina Horta, Furnham, Nicholas

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