Excessive plasma concentration of tricyclic antidepressants resulting from usual doses: a report of six cases

Six patients are described who achieved very high plasma concentrations of imipramine and desipramine during chronic therapy with usual doses. Side effects were minimal. Speculation as to apparent tolerance includes the presence of low metabolite concentrations. Plasma concentration monitoring may b...

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Bibliographic Details
Published in:	The journal of clinical psychiatry Vol. 42; no. 4; p. 143
Main Authors:	Devane, C L, Wolin, R E, Rovere, R A, Panahon, N C, Sutfin, T A, Jusko, W J
Format:	Journal Article
Language:	English
Published:	United States 01-04-1981
Subjects:	Adult Depressive Disorder - blood Depressive Disorder - drug therapy Desipramine - blood Desipramine - therapeutic use Dose-Response Relationship, Drug Female Humans Imipramine - blood Imipramine - therapeutic use Liver Cirrhosis, Alcoholic - blood Male Middle Aged
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Summary:	Six patients are described who achieved very high plasma concentrations of imipramine and desipramine during chronic therapy with usual doses. Side effects were minimal. Speculation as to apparent tolerance includes the presence of low metabolite concentrations. Plasma concentration monitoring may be indicated to identify the occasional patient who achieves potentially toxic plasma concentrations while taking recommended doses of tricyclics.
ISSN:	0160-6689