Search Results - "Pan, Zhenrui"

The Role of mTORC1 Pathway and Autophagy in Resistance to Platinum-Based Chemotherapeutics by Pan, Zhenrui, Zhang, Hanxiao, Dokudovskaya, Svetlana

“…Cisplatin ( -diamminedichloroplatinum I) is a platinum-based drug, the mainstay of anticancer treatment for numerous solid tumors. Since its approval by the…”
Get full text

Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology by Pan, Zhenrui, Zhang, Yuanyuan, Luo, Jianhua, Li, Danyang, Zhou, Yao, He, Liuqing, Yang, Qi, Dong, Min, Tao, Liang

“…Clostridioides difficile toxin B (TcdB) is a key virulence factor that causes C. difficile associated diseases (CDAD) including diarrhea and pseudomembranous…”
Get full text

Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions by Li, Xingxing, He, Liuqing, Luo, Jianhua, Zheng, Yangling, Zhou, Yao, Li, Danyang, Zhang, Yuanyuan, Pan, Zhenrui, Li, Yanyan, Tao, Liang

“…Hemorrhagic toxin (TcsH) is an important exotoxin produced by Paeniclostridium sordellii , but the exact role of TcsH in the pathogenesis remains unclear,…”
Get full text

Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin by Zhou, Yao, Li, Diyin, Luo, Jianhua, Chen, Aizhong, Li, Xingxing, Pan, Zhenrui, Wan, Li, He, Liuqing, Li, Danyang, Li, Yanyan, Dong, Min, Tao, Liang

Get full text

Structural dynamics of the CROPs domain control stability and toxicity of Paeniclostridium sordellii lethal toxin by Zhou, Yao, Zhan, Xiechao, Luo, Jianhua, Li, Diyin, Zhou, Ruoyu, Zhang, Jiahao, Pan, Zhenrui, Zhang, Yuanyuan, Jia, Tianhui, Zhang, Xiaofeng, Li, Yanyan, Tao, Liang

“…Paeniclostridium sordellii lethal toxin (TcsL) is a potent exotoxin that causes lethal toxic shock syndrome associated with fulminant bacterial infections…”
Get full text

Subtyping analysis reveals new variants and accelerated evolution of Clostridioides difficile toxin B by Shen, Enhui, Zhu, Kangli, Li, Danyang, Pan, Zhenrui, Luo, Yun, Bian, Qiao, He, Liuqing, Song, Xiaojun, Zhen, Ying, Jin, Dazhi, Tao, Liang

“…Clostridioides difficile toxins (TcdA and TcdB) are major exotoxins responsible for C. difficile infection (CDI) associated diseases. The previously reported…”
Get full text

Polyphenols from Polygonum cuspidatum Reactivate Latent HIV by Yang, Shuiyuan, Tian, Wenjing, Pan, Zhenrui, Lin, Ting, Wang, Guanghui, Zhou, Qiang, Xue, Yuhua, Chen, Haifeng

Get full text

Design, synthesis, and biological evaluation of AV6 derivatives as novel dual reactivators of latent HIV-1 by Ao, Mingtao, Pan, Zhenrui, Qian, Yuqing, Tang, Bowen, Feng, Zeming, Fang, Hua, Wu, Zhen, Chen, Jingwei, Xue, Yuhua, Fang, Meijuan

“…The "shock and kill" strategy might be a promising therapeutic approach for HIV/AIDS due to the existence of latent viral reservoirs. A major challenge of the…”
Get full text

Quantitative Proteomics of the CDK9 Interactome Reveals a Function of the HSP90-CDC37-P-TEFb Complex for BETi-Induced HIV‑1 Latency Reactivation by Wang, Cong, Chen, Chunjing, Pan, Zhenrui, He, Yaohui, Zhang, Zhanming, Liu, Rongdiao, Xue, Yuhua, Zhou, Qiang, Gao, Xiang

“…Brd4 has been intensively investigated as a promising drug target because of its implicated functions in oncogenesis, inflammation, and HIV-1 transcription…”
Get full text

LncRNA‐LET relieves hypoxia‐induced injury in H9c2 cells through regulation of miR‐138 by Li, Yugeng, Li, Jianwei, Zhang, Pengzhen, Jiang, Xiaoying, Pan, Zhenrui, Zheng, Wenjian, Lin, Hongli

“…Ischemic heart disease (IHD) is a common cardiovascular disease, occurs when coronary artery blood circularity cannot match with the heart's need. The present…”
Get full text

Retracted : LncRNA‐LET relieves hypoxia‐induced injury in H9c2 cells through regulation of miR‐138 by Li, Yugeng, Li, Jianwei, Zhang, Pengzhen, Jiang, Xiaoying, Pan, Zhenrui, Zheng, Wenjian, Lin, Hongli

“…Abstract Ischemic heart disease (IHD) is a common cardiovascular disease, occurs when coronary artery blood circularity cannot match with the heart's need. The…”
Get full text

Polyphenol Extracts from Grape Seeds and Apple Can Reactivate Latent HIV-1 Transcription through Promoting P-TEFb Release from 7SK snRNP by Wang, Cong, Wang, Huiru, Pan, Zhenrui, Wu, Jun, Guo, Yafei, Zhang, Jing, Xiang, Zixun, Lu, Wei, Xue, Yuhua

“…The principal barrier for the eradication of HIV/AIDS is the virus latency. One of the effective strategies so called “shock and kill” is to use…”
Get full text