Search Results - "Pan, Xiaojing"

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution by Shen, Huaizong, Zhou, Qiang, Pan, Xiaojing, Li, Zhangqiang, Wu, Jianping, Yan, Nieng

“…Voltage-gated sodium (Na ) channels are responsible for the initiation and propagation of action potentials. They are associated with a variety of…”
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Structural basis for the modulation of voltage-gated sodium channels by animal toxins by Shen, Huaizong, Li, Zhangqiang, Jiang, Yan, Pan, Xiaojing, Wu, Jianping, Cristofori-Armstrong, Ben, Smith, Jennifer J, Chin, Yanni K Y, Lei, Jianlin, Zhou, Qiang, King, Glenn F, Yan, Nieng

“…Animal toxins that modulate the activity of voltage-gated sodium (Na ) channels are broadly divided into two categories-pore blockers and gating modifiers. The…”
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Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA by Pan Xiaojing, Li Zhangqiang, Huang Xiaoshuang, Huang Gaoxingyu, Gao Shuai, Shen Huaizong, Liu, Lei, Lei Jianlin, Nieng, Yan

“…Targeting sodium channelsVoltage-gated sodium (Nav) channels have been implicated in cardiac and neurological disorders. There are many subtypes of these…”
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Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1 by Pan Xiaojing, Li Zhangqiang, Zhou, Qiang, Shen Huaizong, Wu, Kun, Huang Xiaoshuang, Chen Jiaofeng, Zhang Juanrong, Zhu Xuechen, Lei Jianlin, Xiong, Wei, Gong Haipeng, Xiao Bailong, Nieng, Yan

“…Structures of voltage-gated sodium channelsIn “excitable” cells, like neurons and muscle cells, a difference in electrical potential is used to transmit…”
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Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine by Li, Zhangqiang, Jin, Xueqin, Wu, Tong, Huang, Gaoxingyu, Wu, Kun, Lei, Jianlin, Pan, Xiaojing, Yan, Nieng

“…Nav1.5, the primary voltage‐gated Na+ (Nav) channel in heart, is a major target for class I antiarrhythmic agents. Here we present the cryo‐EM structure of…”
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Structure of human Nav1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome by Li, Zhangqiang, Jin, Xueqin, Wu, Tong, Zhao, Xin, Wang, Weipeng, Lei, Jianlin, Pan, Xiaojing, Yan, Nieng

“…Nav1.5 is the primary voltage-gated Na⁺ (Nav) channel in the heart. Mutations of Nav1.5 are associated with various cardiac disorders exemplified by the type 3…”
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Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2 by Peng, Wei, Shen, Huaizong, Wu, Jianping, Guo, Wenting, Pan, Xiaojing, Wang, Ruiwu, Chen, S. R. Wayne, Yan, Nieng

“…RyR2 is a high-conductance intracellular calcium (Ca ) channel that controls the release of Ca from the sarco(endo)plasmic reticulum of a variety of cells…”
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Structural mapping of Nav1.7 antagonists by Wu, Qiurong, Huang, Jian, Fan, Xiao, Wang, Kan, Jin, Xueqin, Huang, Gaoxingyu, Li, Jiaao, Pan, Xiaojing, Yan, Nieng

“…Voltage-gated sodium (Na v ) channels are targeted by a number of widely used and investigational drugs for the treatment of epilepsy, arrhythmia, pain, and…”
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Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies by Pan, Xiaojing, Li, Zhangqiang, Jin, Xueqin, Zhao, Yanyu, Huang, Gaoxingyu, Huang, Xiaoshuang, Shen, Zilin, Cao, Yong, Dong, Mengqiu, Lei, Jianlin, Yan, Nieng

“…Among the nine subtypes of human voltage-gated sodium (Nav) channels, the brain and cardiac isoforms, Nav1.1 and Nav1.5, each carry more than 400 missense…”
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Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors by Deng, Dong, Yan, Chuangye, Pan, Xiaojing, Mahfouz, Magdy, Wang, Jiawei, Zhu, Jian-Kang, Shi, Yigong, Yan, Nieng

“…TAL (transcription activator-like) effectors, secreted by phytopathogenic bacteria, recognize host DNA sequences through a central domain of tandem repeats…”
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The therapeutic efficacy of CdTe and CdSe quantum dots for photothermal cancer therapy by Chu, Maoquan, Pan, Xiaojing, Zhang, Ding, Wu, Qiang, Peng, Jinliang, Hai, Wangxi

“…Abstract Fluorescent quantum dots (QDs) used for biomedical imaging and diagnostics have attracted considerable attention over the past decade. Here, we report…”
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Structural basis for urate recognition and apigenin inhibition of human GLUT9 by Shen, Zilin, Xu, Li, Wu, Tong, Wang, Huan, Wang, Qifan, Ge, Xiaofei, Kong, Fang, Huang, Gaoxingyu, Pan, Xiaojing

“…Urate, the physiological form of uric acid and a potent antioxidant in serum, plays a pivotal role in scavenging reactive oxygen species. Yet excessive…”
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A comparison of IOLMaster 500 and IOLMaster 700 in the measurement of ocular biometric parameters in cataract patients by Jiang, Jianhong, Pan, Xiaojing, Zhou, Mingming, Wang, Xiaoyun, Zhu, Hai, Li, Dongfang

“…To compare the agreement of ocular biometric parameters measured by IOLMaster 500 and IOLMaster 700. This is a prospective study. IOLMaster 500 and IOLMaster…”
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Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na⁺ channels in nanodisc by Gao, Shuai, Valinsky, William C., On, Nguyen Cam, Houlihan, Patrick R., Qu, Qian, Liu, Lei, Pan, Xiaojing, Clapham, David E., Yan, Nieng

“…NaChBac, the first bacterial voltage-gated Na⁺ (Nav) channel to be characterized, has been the prokaryotic prototype for studying the structure–function…”
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Correlation between temporomandibular joints and craniocervical posture in patients with bilateral anterial disc displacement by Xiang, Wanfang, Wang, Min, Li, Zhihui, Cai, Mingqin, Pan, Xiaojing

“…To study the changes of temporomandibular joints and craniocervical posture in adult patients with bilateral anterior disc displacement, and to explore their…”
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TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism by Munson, Mary, Eathiraj, Sudharshan, Pan, Xiaojing, Lambright, David G

“…Rab GTPases regulate membrane trafficking by cycling between inactive (GDP-bound) and active (GTP-bound) conformations. The duration of the active state is…”
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Long-term outcomes of “open iridectomy” for secondary anterior chamber epithelial iris cysts by Lan, Jie, Liu, Ting, Huang, Yusen, Pan, Xiaojing, Wei, Yufen, Xie, Pingzhong, Kong, Qianqian, Guo, Xiang, Xie, Lixin

“…Epithelial cysts run a high risk of recurrence and conversion to sheet-like ingrowth after surgical intervention. In this retrospective study, we introduced a…”
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Structure of a bacterial energy-coupling factor transporter by Wang, Tingliang, Fu, Guobin, Pan, Xiaojing, Wu, Jianping, Gong, Xinqi, Wang, Jiawei, Shi, Yigong

“…The crystal structure of a nucleotide-free energy-coupling factor transporter from Lactobacillus brevis at a resolution of 3.5 Å suggests a plausible working…”
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Efficacy and safety of single Ultrasound Cyclo-Plasty to treat refractory glaucoma: Results at 1 year by Longfang, Zhou, Die, Hu, Jie, Lan, Yameng, Liu, Mingyuan, Lv, Xiaojing, Pan

“…Purpose: To evaluate clinical efficacy and safety of single Ultrasound Cyclo-Plasty (UCP) in the treatment of advanced refractory glaucoma. Methods: From…”
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Aqueous humour outflow imaging: seeing is believing by Lee, Jong Yeon, Akiyama, Goichi, Saraswathy, Sindhu, Xie, Xiaobin, Pan, Xiaojing, Hong, Young-Kwon, Huang, Alex S.

“…Elevated intraocular pressure (IOP) is the primary risk factor for blindness in glaucoma. IOP is determined by many factors including aqueous humour production…”
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