Search Results - "Pan, Xiaobei"

Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome by Pan, Xiaobei, Nasaruddin, Muhammad Bin, Elliott, Christopher T, McGuinness, Bernadette, Passmore, Anthony P, Kehoe, Patrick G, Hölscher, Christian, McClean, Paula L, Graham, Stewart F, Green, Brian D

“…Abstract The pathogenesis of Alzheimer's disease (AD) is complex involving multiple contributing factors. The extent to which AD pathology affects the…”
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Metabolomic Profiling of Bile Acids in Clinical and Experimental Samples of Alzheimer's Disease by Pan, Xiaobei, Elliott, Christopher T, McGuinness, Bernadette, Passmore, Peter, Kehoe, Patrick G, Hölscher, Christian, McClean, Paula L, Graham, Stewart F, Green, Brian D

“…Certain endogenous bile acids have been proposed as potential therapies for ameliorating Alzheimer's disease (AD) but their role, if any, in the…”
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Metabolomics and computational analysis of the role of monoamine oxidase activity in delirium and SARS-COV-2 infection by Cuperlovic-Culf, Miroslava, Cunningham, Emma L., Teimoorinia, Hossen, Surendra, Anuradha, Pan, Xiaobei, Bennett, Steffany A. L., Jung, Mijin, McGuiness, Bernadette, Passmore, Anthony Peter, Beverland, David, Green, Brian D.

“…Delirium is an acute change in attention and cognition occurring in ~ 65% of severe SARS-CoV-2 cases. It is also common following surgery and an indicator of…”
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Cerebrospinal Fluid Spermidine, Glutamine and Putrescine Predict Postoperative Delirium Following Elective Orthopaedic Surgery by Pan, Xiaobei, Cunningham, Emma L., Passmore, Anthony P., McGuinness, Bernadette, McAuley, Daniel F., Beverland, David, O’Brien, Seamus, Mawhinney, Tim, Schott, Jonathan M., Zetterberg, Henrik, Green, Brian D.

“…Delirium is a marker of brain vulnerability, associated with increasing age, pre-existing cognitive impairment and, recently, cerebrospinal fluid (CSF)…”
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Dietary inclusion of nitrite-containing frankfurter exacerbates colorectal cancer pathology and alters metabolism in APCmin mice by Crowe, William, Pan, Xiaobei, Mackle, James, Harris, Adam, Hardiman, Gary, Elliott, Christopher T., Green, Brian D.

“…Colorectal cancer (CRC) is the second most prevelant malignancy in Europe and diet is an important modifiable risk factor. Processed meat consumption,…”
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Quinolone Alkaloids from Fructus Euodiae Show Activity Against Methicillin-Resistant Staphylococcus aureus by Pan, Xiaobei, Bligh, S. W. Annie, Smith, Eileen

“…Fructus Euodiae is used in Traditional Chinese Medicine to treat infection. In this study, four of the quinolone alkaloids isolated from Fructus Euodiae showed…”
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Plasma metabolites distinguish dementia with Lewy bodies from Alzheimer's disease: a cross-sectional metabolomic analysis by Pan, Xiaobei, Donaghy, Paul C, Roberts, Gemma, Chouliaras, Leonidas, O'Brien, John T, Thomas, Alan J, Heslegrave, Amanda J, Zetterberg, Henrik, McGuinness, Bernadette, Passmore, Anthony P, Green, Brian D, Kane, Joseph P M

“…In multifactorial diseases, alterations in the concentration of metabolites can identify novel pathological mechanisms at the intersection between genetic and…”
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Metabolomic changes in tear fluid following zinc biofortification in the BiZiFED nutritional study: a feasibility study by Brown, Connor N, Shahzad, Babar, Zaman, Mukhtiar, Pan, Xiaobei, Green, Brian D, Lowe, Nicola M, Lengyel, Imre

“…Biofortified Zinc Flour to Eliminate Deficiency in Pakistan (BiZiFED) is a nutritional research program that evaluates the impact of consuming zinc…”
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Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells by Pan, Xiaobei, Hartley, Janet M., Hartley, John A., White, Kenneth N., Wang, Zhengtao, Bligh, S.W. Annie

“…DNA topoisomerases are nuclear enzymes that are the targets for several anticancer drugs. In this study we investigated the antiproliferative activity against…”
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The Health Promoting Bioactivities of Lactuca sativa can be Enhanced by Genetic Modulation of Plant Secondary Metabolites by Ismail, Hammad, Gillespie, Anna L, Calderwood, Danielle, Iqbal, Haroon, Gallagher, Colene, Chevallier, Olivier P, Elliott, Christopher T, Pan, Xiaobei, Mirza, Bushra, Green, Brian D

“…Plant secondary metabolites are protective dietary constituents and genes evidently increase the synthesis of these versatile phytochemicals. This study…”
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Evidence That Parietal Lobe Fatty Acids May Be More Profoundly Affected in Moderate Alzheimer's Disease (AD) Pathology Than in Severe AD Pathology by Nasaruddin, Muhammad L, Pan, Xiaobei, McGuinness, Bernadette, Passmore, Peter, Kehoe, Patrick G, Hölscher, Christian, Graham, Stewart F, Green, Brian D

“…Brain is a lipid-rich tissue, and fatty acids (FAs) play a crucial role in brain function, including neuronal cell growth and development. This study used…”
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The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and their Associations with the Incidence of Postoperative Delirium by Jung, Mijin, Pan, Xiaobei, Cunningham, Emma L, Passmore, Anthony P, McGuinness, Bernadette, McAuley, Daniel F, Beverland, David, O'Brien, Seamus, Mawhinney, Tim, Schott, Jonathan M, Zetterberg, Henrik, Green, Brian D

“…The mechanisms underlying the occurrence of postoperative delirium development are unclear and measurement of plasma metabolites may improve understanding of…”
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Abstract 1039 Quantifying the levels of Queuosine metabolites in the human diet by Chandrasekaran, Swathine, Pan, Xiaobei, Woodside, Jayne, Green, Brian

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Temporal Effects of Neuron-specific beta-secretase 1 (BACE1) Knock-in on the Mouse Brain Metabolome: Implications for Alzheimer's Disease by Pan, Xiaobei, Green, Brian D.

“…•Neuron-specific knock-in of human BACE1 age-dependently affects the brain metabolome.•More brain metabolites were significantly altered in ‘old’ PLB4 mice…”
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Development, validation and application of an LC–MS/MS method quantifying free forms of the micronutrients queuine and queuosine in human plasma using a surrogate matrix approach by Pan, Xiaobei, Chandrasekaran, Swathine, Woodside, Jayne V., Riedel-Heller, Steffi G., Scherer, Martin, Wagner, Michael, Ramirez, Alfredo, Green, Brian D.

“…Queuosine (Q) is a hypermodified 7-deaza-guanosine nucleoside exclusively synthesized by bacteria. This micronutrient and its respective nucleobase form…”
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Targeted biochemical profiling of brain from Huntington's disease patients reveals novel metabolic pathways of interest by Graham, Stewart F., Pan, Xiaobei, Yilmaz, Ali, Macias, Shirin, Robinson, Andrew, Mann, David, Green, Brian D.

“…Huntington's disease (HD) is a devastating, progressive neurodegenerative disease with a distinct phenotype characterized by chorea and dystonia,…”
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Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate by Hung, Shr-Hau, Elliott, Gregory I, Ramkumar, Thakku R, Burtnyak, Lyubomyr, McGrenaghan, Callum J, Alkuzweny, Sana, Quaiyum, Samia, Iwata-Reuyl, Dirk, Pan, Xiaobei, Green, Brian D, Kelly, Vincent P, de Crécy-Lagard, Valérie, Swairjo, Manal A

“…Eukaryotic life benefits from-and ofttimes critically relies upon-the de novo biosynthesis and supply of vitamins and micronutrients from bacteria. The…”
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Dynamic queuosine changes in tRNA couple nutrient levels to codon choice in Trypanosoma brucei by Dixit, Sameer, Kessler, Alan C, Henderson, Jeremy, Pan, Xiaobei, Zhao, Ruoxia, D’Almeida, Gabriel Silveira, Kulkarni, Sneha, Rubio, Mary Anne T, Hegedűsová, Eva, Ross, Robert L, Limbach, Patrick A, Green, Brian D, Paris, Zdeněk, Alfonzo, Juan D

“…Abstract Every type of nucleic acid in cells undergoes programmed chemical post-transcriptional modification. Generally, modification enzymes use substrates…”
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Dietary inclusion of nitrite-containing frankfurter exacerbates colorectal cancer pathology and alters metabolism in APC min mice by Crowe, William, Pan, Xiaobei, Mackle, James, Harris, Adam, Hardiman, Gary, Elliott, Christopher T, Green, Brian D

“…Colorectal cancer (CRC) is the second most prevelant malignancy in Europe and diet is an important modifiable risk factor. Processed meat consumption,…”
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Detailed characterisation of STC-1 cells and the pGIP/Neo sub-clone suggests the incretin hormones are translationally regulated by Gillespie, Anna L., Pan, Xiaobei, Marco-Ramell, Anna, Meharg, Caroline, Green, Brian D.

“…•pGIP/Neo cells are STC-1 cells transfected with a plasmid encoding the GIP promoter.•Glucagon-like peptide-1 (GLP-1) and GLP-2 were lower in pGIP/Neo cells…”
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