Search Results - "Pan, Jin‐Xiu"

Clinical features of LRP4/agrin‐antibody–positive myasthenia gravis: A multicenter study by Rivner, Michael H., Quarles, Brandy M., Pan, Jin‐Xiu, Yu, Zheng, Howard, James F., Corse, Andrea, Dimachkie, Mazen M., Jackson, Carlayne, Vu, Tuan, Small, George, Lisak, Robert P., Belsh, Jerry, Lee, Ikjae, Nowak, Richard J., Baute, Vanessa, Scelsa, Stephen, Fernandes, J. Americo, Simmons, Zachary, Swenson, Andrea, Barohn, Richard, Sanka, R. Bhavaraju, Gooch, Clifton, Ubogu, Eroboghene, Caress, James, Pasnoor, Mamatha, Xu, Hongyan, Mei, Lin

“…Introduction Our aim in this study was to identify the prevalence and clinical characteristics of LRP4/agrin‐antibody–positive double‐seronegative myasthenia…”
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YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating β-catenin signaling by Pan, Jin-Xiu, Xiong, Lei, Zhao, Kai, Zeng, Peng, Wang, Bo, Tang, Fu-Lei, Sun, Dong, Guo, Hao-Han, Yang, Xiao, Cui, Shun, Xia, Wen-Fang, Mei, Lin, Xiong, Wen-Cheng

“…YAP (yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo pathway, a conserved pathway for the development and size…”
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Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption by Xiong, Lei, Jung, Ji-Ung, Wu, Haitao, Xia, Wen-Fang, Pan, Jin-Xiu, Shen, Chengyong, Mei, Lin, Xiong, Wen-Cheng

“…Significance This study provides in vivo evidence that Lrp4 loss in osteoblast (OB)-lineage cells results in high–bone-mass deficit. Lrp4 in OB-lineage cells…”
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Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency by Xiong, Lei, Zhao, Kai, Cao, Yu, Guo, Hao-Han, Pan, Jin-Xiu, Yang, Xiao, Ren, Xiao, Mei, Lin, Xiong, Wen-Cheng

“…The nuclear lamina protein lamin A/C is a key component of the nuclear envelope. Mutations in the lamin A/C gene (LMNA) are identified in patients with various…”
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Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast‐Lineage Cells by Wang, Bo, Pan, Jin‐Xiu, Yu, Huali, Xiong, Lei, Zhao, Kai, Xiong, Shan, Guo, Jun‐Peng, Lin, Sen, Sun, Dong, Zhao, Lu, Guo, Haohan, Mei, Lin, Xiong, Wen‐Cheng

“…ABSTRACT Normal bone mass is maintained by balanced bone formation and resorption. Myosin X (Myo10), an unconventional “myosin tail homology 4‐band 4.1, ezrin,…”
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Linking cortical astrocytic neogenin deficiency to the development of Moyamoya disease–like vasculopathy by Ren, Xiao, Yao, Ling-Ling, Pan, Jin-Xiu, Zhang, Jun-Shi, Mei, Lin, Wang, Yong-Gang, Xiong, Wen-Cheng

“…Moyamoya-like vasculopathy, the “puff of smoke”-like small vessels in the brain, is initially identified in patients with Moyamoya disease (MMD), a rare…”
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Hippocampal astrocytic neogenin regulating glutamate uptake, a critical pathway for preventing epileptic response by Sun, Dong, Tan, Zhi-Bing, Sun, Xiang-Dong, Liu, Zhi-Peng, Chen, Wen-Bing, Milibari, Leena, Ren, Xiao, Yao, Ling-Ling, Lee, Daehoon, Shen, Chen, Pan, Jin-Xiu, Huang, Zhi-Hui, Mei, Lin, Xiong, Wen-Cheng

“…Epilepsy, a common neurological disorder, is featured with recurrent seizures. Its underlying pathological mechanisms remain elusive. Here, we provide evidence…”
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APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress by Pan, Jin-Xiu, Tang, Fulei, Xiong, Fei, Xiong, Lei, Zeng, Peng, Wang, Bo, Zhao, Kai, Guo, Haohan, Shun, Cui, Xia, Wen-Fang, Mei, Lin, Xiong, Wen-Cheng

“…Amyloid precursor protein (APP) is ubiquitously expressed in various types of cells including bone cells. Mutations in App gene result in early-onset…”
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Muscular Swedish mutant APP-to-Brain axis in the development of Alzheimer’s disease by Pan, Jin-Xiu, Lee, Daehoon, Sun, Dong, Zhao, Kai, Xiong, Lei, Guo, Hao-Han, Ren, Xiao, Chen, Peng, Lopez de Boer, Raquel, Lu, Yuyi, Lin, Helena, Mei, Lin, Xiong, Wen-Cheng

“…Alzheimer’s disease (AD) is the most common form of dementia. Notably, patients with AD often suffer from severe sarcopenia. However, their direct link and…”
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Osteoblastic Lrp4 promotes osteoclastogenesis by regulating ATP release and adenosine-A2AR signaling by Xiong, Lei, Jung, Ji-Ung, Guo, Hao-Han, Pan, Jin-Xiu, Sun, Xiang-Dong, Mei, Lin, Xiong, Wen-Cheng

“…Bone homeostasis depends on the functional balance of osteoblasts (OBs) and osteoclasts (OCs). Lrp4 is a transmembrane protein that is mutated in patients with…”
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Hepcidin contributes to Swedish mutant APP-induced osteoclastogenesis and trabecular bone loss by Guo, Hao-Han, Xiong, Lei, Pan, Jin-Xiu, Lee, Daehoon, Liu, Kevin, Ren, Xiao, Wang, Bo, Yang, Xiao, Cui, Shun, Mei, Lin, Xiong, Wen-Cheng

“…Patients with Alzheimer's disease (AD) often have lower bone mass than healthy individuals. However, the mechanisms underlying this change remain elusive…”
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Iron Chelation Inhibits Osteoclastic Differentiation In Vitro and in Tg2576 Mouse Model of Alzheimer's Disease by Guo, Jun-Peng, Pan, Jin-Xiu, Xiong, Lei, Xia, Wen-Fang, Cui, Shun, Xiong, Wen-Cheng

“…Patients of Alzheimer's disease (AD) frequently have lower bone mineral density and higher rate of hip fracture. Tg2576, a well characterized AD animal model…”
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Parkinson's in the bone by Xiong, Lei, Pan, Jin-Xiu, Guo, Hao-han, Mei, Lin, Xiong, Wen-Cheng

“…Abstract Patients with Parkinson’s disease (PD) exhibit systemic deficits, including arthritis and osteoporosis-like symptoms. However, the questions, how the…”
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Osteoblastic Swedish mutant APP expedites brain deficits by inducing endoplasmic reticulum stress-driven senescence by Pan, Jin-Xiu, Sun, Dong, Lee, Daehoon, Xiong, Lei, Ren, Xiao, Guo, Hao-han, Yao, Ling-Ling, Lu, Yuyi, Jung, Caroline, Xiong, Wen-Cheng

“…Patients with Alzheimer’s disease (AD) often have osteoporosis or osteopenia. However, their direct link and relationship remain largely unclear. Previous…”
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Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response by Xiong, Lei, Xia, Wen-Fang, Tang, Fu-Lei, Pan, Jin-Xiu, Mei, Lin, Xiong, Wen-Cheng

“…Parathyroid hormone (PTH) plays critical, but distinct, roles in bone remodeling, including bone formation (anabolic response) and resorption (catabolic…”
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Critical Roles of Embryonic Born Dorsal Dentate Granule Neurons for Activity-Dependent Increases in BDNF, Adult Hippocampal Neurogenesis, and Antianxiety-like Behaviors by Sun, Dong, Milibari, Leena, Pan, Jin-Xiu, Ren, Xiao, Yao, Ling-Ling, Zhao, Yang, Shen, Chen, Chen, Wen-Bing, Tang, Fu-Lei, Lee, Daehoon, Zhang, Jun-Shi, Mei, Lin, Xiong, Wen-Cheng

“…Dentate gyrus (DG), a “gate” that controls information flow into the hippocampus, plays important roles in regulating both cognitive (e.g., spatial learning…”
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Induction of Anti-agrin Antibodies Causes Myasthenia Gravis in Mice by Yan, Min, Liu, Ziyang, Fei, Erkang, Chen, Wenbing, Lai, Xinsheng, Luo, Bin, Chen, Peng, Jing, Hongyang, Pan, Jin-xiu, Rivner, Michael H., Xiong, Wen-Cheng, Mei, Lin

“…•Immunization with recombinant agrin reduces muscle strength.•The morphology and function of the neuromuscular junction are compromised in immunized…”
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Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development by Yu, Hua-Li, Peng, Yun, Zhao, Yang, Lan, Yong-Sheng, Wang, Bo, Zhao, Lu, Sun, Dong, Pan, Jin-Xiu, Dong, Zhao-Qi, Mei, Lin, Ding, Yu-Qiang, Zhu, Xiao-Juan, Xiong, Wen-Cheng

“…Myosin X (Myo X) transports cargos to the tips of filopodia for cell adhesion, migration, and neuronal axon guidance. Deleted in Colorectal Cancer (DCC) is one…”
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Neogenin in Amygdala for Neuronal Activity and Information Processing by Sun, Xiang-Dong, Chen, Wen-Bing, Sun, Dong, Huang, Jie, Li, Yuan-Quan, Pan, Jin-Xiu, Wang, Ya-Nan, Zhao, Kai, Dong, Zhao-Qi, Wang, Hong-Sheng, Xiong, Lei, Xuan, Aiguo, Zhao, Shen-Ting, Pillai, Anilkumar, Xiong, Wen-Cheng, Mei, Lin

“…Fear learning and memory are vital for livings to survive, dysfunctions in which have been implicated in various neuropsychiatric disorders. Appropriate…”
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Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior by Sun, Dong, Sun, Xiang-Dong, Zhao, Lu, Lee, Dae-Hoon, Hu, Jin-Xia, Tang, Fu-Lei, Pan, Jin-Xiu, Mei, Lin, Zhu, Xiao-Juan, Xiong, Wen-Cheng

“…Adult neurogenesis in hippocampal dentate gyrus (DG) is a complex, but precisely controlled process. Dysregulation of this event contributes to multiple…”
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