Search Results - "Pan, Hongchao"

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years by Pan, Hongchao, Gray, Richard, Braybrooke, Jeremy, Davies, Christina, Taylor, Carolyn, McGale, Paul, Peto, Richard, Pritchard, Kathleen I, Bergh, Jonas, Dowsett, Mitch, Hayes, Daniel F

“…In a meta-analysis of 88 trials involving nearly 63,000 women with breast cancer who were disease-free after 5 years of endocrine therapy, the risk of…”
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Expression and function of chondroitin 4‐sulfate and chondroitin 6‐sulfate in human glioma by Pan, Hongchao, Xue, Weikang, Zhao, Weijiang, Schachner, Melitta

“…Key molecules promoting migration and invasion exist in the extracellular matrix, and include chondroitin 4‐sulfate (C4S) and chondroitin 6‐sulfate (C6S),…”
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Considerations in boosting COVID-19 vaccine immune responses by Krause, Philip R, Fleming, Thomas R, Peto, Richard, Longini, Ira M, Figueroa, J Peter, Sterne, Jonathan A C, Cravioto, Alejandro, Rees, Helen, Higgins, Julian P T, Boutron, Isabelle, Pan, Hongchao, Gruber, Marion F, Arora, Narendra, Kazi, Fatema, Gaspar, Rogerio, Swaminathan, Soumya, Ryan, Michael J, Henao-Restrepo, Ana-Maria

“…A new wave of COVID-19 cases caused by the highly transmissible delta variant is exacerbating the worldwide public health crisis, and has led to consideration…”
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Histone deacetylase 2 knockout suppresses immune escape of triple-negative breast cancer cells via downregulating PD-L1 expression by Xu, Pengfei, Xiong, Wei, Lin, Yun, Fan, Liping, Pan, Hongchao, Li, Yaochen

“…The PD-L1 overexpression is an important event of immune escape and metastasis in triple-negative breast cancer (TNBC), but the molecular mechanism remains to…”
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Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group by Nielsen, Torsten O, Leung, Samuel C. Y, Rimm, David L, Dodson, Andrew, Acs, Balazs, Badve, Sunil, Denkert, Carsten, Ellis, Matthew J, Fineberg, Susan, Flowers, Margaret, Kreipe, Hans H, Laenkholm, Anne-Vibeke, Pan, Hongchao, Penault-Llorca, Frédérique M, Polley, Mei-Yin, Salgado, Roberto, Smith, Ian E, Sugie, Tomoharu, Bartlett, John M. S, McShane, Lisa M, Dowsett, Mitch, Hayes, Daniel F

“…Abstract Ki67 immunohistochemistry (IHC), commonly used as a proliferation marker in breast cancer, has limited value for treatment decisions due to…”
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Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial by Davies, Christina, Dr, Pan, Hongchao, PhD, Godwin, Jon, DPhil, Gray, Richard, Prof, Arriagada, Rodrigo, Prof, Raina, Vinod, Prof, Abraham, Mirta, MD, Alencar, Victor Hugo Medeiros, MD, Badran, Atef, PhD, Bonfill, Xavier, MD, Bradbury, Joan, Clarke, Michael, Prof, Collins, Rory, Prof, Davis, Susan R, Prof, Delmestri, Antonella, PhD, Forbes, John F, Prof, Haddad, Peiman, Prof, Hou, Ming-Feng, Prof, Inbar, Moshe, Prof, Khaled, Hussein, Prof, Kielanowska, Joanna, MD, Kwan, Wing-Hong, MD, Mathew, Beela S, MD, Mittra, Indraneel, Prof, Müller, Bettina, MD, Nicolucci, Antonio, MD, Peralta, Octavio, MD, Pernas, Fany, Petruzelka, Lubos, Prof, Pienkowski, Tadeusz, Prof, Radhika, Ramachandran, MD, Rajan, Balakrishnan, MD, Rubach, Maryna T, MD, Tort, Sera, MD, Urrútia, Gerard, MD, Valentini, Miriam, MD, Wang, Yaochen, MD, Peto, Richard, Prof

“…Summary Background For women with oestrogen receptor (ER)-positive early breast cancer, treatment with tamoxifen for 5 years substantially reduces the breast…”
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ARSD, a novel ERα downstream target gene, inhibits proliferation and migration of breast cancer cells via activating Hippo/YAP pathway by Lin, Yun, Li, Chun, Xiong, Wei, Fan, Liping, Pan, Hongchao, Li, Yaochen

“…Advanced breast cancer (BC), especially basal like triple-negative BC (TNBC), is a highly malignant tumor without viable treatment option, highlighting the…”
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ARSD is responsible for carcinoma and amyloidosis of breast epithelial cells by Lin, Yun, Fan, Liping, Zhang, Rendong, Pan, Hongchao, Li, Yaochen

“…Breast cancer (BC) and Alzheimer's disease (AD) have pronounced female-to-male disparities and both are the major causes of death in elderly women…”
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Avoiding 40% of the premature deaths in each country, 2010–30: review of national mortality trends to help quantify the UN Sustainable Development Goal for health by Norheim, Ole F, Prof, Jha, Prabhat, Prof, Admasu, Kesetebirhan, MD, Godal, Tore, MD, Hum, Ryan J, MEng, Kruk, Margaret E, MD, Gómez-Dantés, Octavio, MD, Mathers, Colin D, PhD, Pan, Hongchao, PhD, Sepúlveda, Jaime, Prof, Suraweera, Wilson, MSc, Verguet, Stéphane, PhD, Woldemariam, Addis T, MD, Yamey, Gavin, MD, Jamison, Dean T, Prof, Peto, Richard, Prof

“…Summary Background The UN will formulate ambitious Sustainable Development Goals for 2030, including one for health. Feasible goals with some quantifiable,…”
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10-year stroke prevention after successful carotid endarterectomy for asymptomatic stenosis (ACST-1): a multicentre randomised trial by Halliday, Alison, Prof, Harrison, Michael, Prof, Hayter, Elizabeth, BMus, Kong, Xiangling, MSc, Mansfield, Averil, Prof, Marro, Joanna, MSc, Pan, Hongchao, PhD, Peto, Richard, Prof, Potter, John, Prof, Rahimi, Kazem, DM, Rau, Angela, MBBS, Robertson, Steven, BA, Streifler, Jonathan, MD, Thomas, Dafydd, Prof

“…Summary Background If carotid artery narrowing remains asymptomatic (ie, has caused no recent stroke or other neurological symptoms), successful carotid…”
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Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice by Xu, Junping, Hu, Chengliang, Jiang, Qiong, Pan, Hongchao, Shen, Huifan, Schachner, Melitta

“…Curing spinal cord injury (SCI) in mammals is a daunting task because of the lack of permissive mechanisms and strong inhibitory responses at and around the…”
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Everestmab, a novel long-acting GLP-1/anti GLP-1R nanobody fusion protein, exerts potent anti-diabetic effects by Pan, Hongchao, Su, Yunnan, Xie, Yini, Wang, Weiyong, Qiu, Wanli, Chen, Wei, Lu, Wenying, Lu, Zhao, Wang, Weiwei, Shang, Anquan

“…In the present study, a novel single domain antibody (sdAb) fusion protein, named everestmab, composing of a mutated GLP-1(A8G) fused to the tandem bispecific…”
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Risk of Stroke From New Carotid Artery Occlusion in the Asymptomatic Carotid Surgery Trial-1 by DEN HARTOG, Anne G, HALLIDAY, Alison W, HAYTER, Elizabeth, HONGCHAO PAN, XING KONG, MOLL, Frans L, DE BORST, Gert Jan

“…In the Asymptomatic Carotid Surgery Trial-1 (ACST-1), 3120 patients with tight asymptomatic carotid stenosis were randomly assigned to medical treatment alone…”
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Relationship between Chromosome 18q Status and Colorectal Cancer Prognosis: A Prospective, Blinded Analysis of 280 Patients by Popat, Sanjay, Zhao, Dongbing, Chen, Zhengming, Pan, Hongchao, Shao, Yongfu, Chandler, Ian, Houlston, Richard S

“…Background: The relationship between chromosome 18q allelic imbalance (AI) and survival in colorectal cancer (CRC) is unclear, and study design may have…”
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Tobacco smoking and the risk of Parkinson disease: A 65-year follow-up of 30,000 male British doctors by Mappin-Kasirer, Benjamin, Pan, Hongchao, Lewington, Sarah, Kizza, Jennifer, Gray, Richard, Clarke, Robert, Peto, Richard

“…OBJECTIVETo investigate the causal relevance of current tobacco smoking for the risk of Parkinson disease (PD). METHODSWe compared the risks of death from PD…”
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A Novel Immune-Related Signature to Predict Prognosis and Immune Infiltration of Cervical Cancer by Lin, Yun, Zhang, Rendong, Pan, Hongchao, Li, Yaochen

“…BACKGROUND Cervical cancer is one of the most common malignances among women globally. This study aimed to construct a novel immune-related signature to…”
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Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses by Pan, Hongchao, Peto, Richard, Henao Restrepo, Ana Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Karim, Quarraisha Abdool, Alejandria, Marissa, Hernàndez García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K. Srinath, Periago, Mirta Roses, Hanna, Pierre Abi, Abutidze, Akaki, Ader, Florence, Al-Bader, Abdullah, Alhasawi, Almonther, Allum, Emma, Al Mawali, Adhra, Alotaibi, Athari, Alvarez- Moreno, Carlos, Appadoo, Sheila, Arts, Derk, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Genetu Bayih, Abebe, Beaumont, Helena, Bellani, Samir, Benassi, Virginia, Bhargava, Balram, Branca, Mattia, Cappel-Porter, Heike, Cerrato, Nery, Cheick Haidara, Fadima, Chow, Ting Soo, Como, Nadia, Eustace, Joe, Gabunia, Tamar, García, Patricia, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Hassan, Mariam, Hassany, Mohamed, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Khamis, Faryal, Kirwan, Jana, Kumar, Suresh, Lennon, Peter, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Manevska, Suzana, Manuel, Oriol, McGinty, Sybil, Medina, Marco, Mesa Rubio, Maria Lucia, Miranda Montoya, Maria Consuelo, Nel, Jeremy, Nunes, Estevao, Perola, Markus, Portoles, Antonio, Rasmin, Menaldi, Raza, Aun, Rees, Helen, Reges, Paula, Rogers, Chris, Salami, Kolawole, Salvadori, Marina, Sauermann, Mamatha, Sinani, Narvina, Sow, Samba, Sterne, Jonathan AC, Stevanovikj, Milena, Tacconelli, Evelina, Tavares Maltez, Fernando Manuel, Teferi, Mekonnen, Tikkinen, Kari, Trelle, Sven, Tsertsvadze, Tengiz, Zaid, Hala, Røttingen, John-Arne, Swaminathan, Soumya, Ryan, Michael, Gjermeni, Nevila, Meta, Esmeralda, Aguila, Damian, Alonso, Ignacio, Altamirano, Marcos, Alvarez, María, Alzola, Rodrigo, Arce, Veronica, Arribillaga, Patricia, Avila, Rafael, Balbuena, Juan

“…The Solidarity trial among COVID-19 inpatients has previously reported interim mortality analyses for four repurposed antiviral drugs. Lopinavir,…”
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10 vs 5 years of adjuvant tamoxifen: exclusion of 1/402 centres in ATLAS by Davies, Christina, Pan, Hongchao, Peto, Richard

“…ATLAS is an international trial of the main effects of prolonging adjuvant tamoxifen. It involves 15 000 women with early breast cancer, randomised in…”
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Forkhead box C1 boosts triple‐negative breast cancer metastasis through activating the transcription of chemokine receptor‐4 by Pan, Hongchao, Peng, Zhilan, Lin, Jiediao, Ren, Xiaosha, Zhang, Guojun, Cui, Yukun

“…The transcription factor forkhead box C1 (FOXC1) has recently been proposed as a crucial regulator of triple‐negative breast cancer (TNBC) and associated with…”
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Reciprocal regulation of forkhead box C1 and L1 cell adhesion molecule contributes to triple-negative breast cancer progression by Zhang, Fan, Xu, Yue, Lin, Jiediao, Pan, Hongchao, Giuliano, Armando E., Cui, Xiaojiang, Cui, Yukun

“…Purpose The potential of targeting forkhead box C1 (FOXC1) as a therapeutic approach for triple-negative breast cancer (TNBC) is promising. However, a…”
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