Search Results - "Pan, Gonghua"

Associations between T-cell traits and narcolepsy type 1: new insights from a Mendelian randomization study by Chen, Shiqin, Lv, Tian, Li, Zongshan, Pan, Gonghua, Chen, Yiqiao, Zhao, Xingwang, Zhang, Lisan

“…Background Narcolepsy type 1 (NT1) is primarily caused by a malfunctioning immune system in which T-cells damage the hypothalamus. To elucidate the causal…”
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Heart failure causally affects the brain cortical structure: a Mendelian randomization study by Meng, Tianjiao, Fei, Qinwen, Zhu, Jingying, Gu, Jiayi, Li, Weiyu, Wu, Xianhong, Pan, Gonghua, Lv, Tian, Chen, Shiqin

“…The effects of heart failure (HF) on cortical brain structure remain unclear. Therefore, the present study aimed to investigate the causal effects of heart…”
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Synthesis and structure based optimization of novel Akt inhibitors by Lippa, Blaise, Pan, Gonghua, Corbett, Matthew, Li, Chao, Kauffman, Goss S., Pandit, Jayvardhan, Robinson, Shaughnessy, Wei, Liuqing, Kozina, Ekaterina, Marr, Eric S., Borzillo, Gary, Knauth, Elisabeth, Barbacci-Tobin, Elsa G., Vincent, Patrick, Troutman, Merin, Baker, Deborah, Rajamohan, Francis, Kakar, Shefali, Clark, Tracey, Morris, Joel

“…Akt1 X-ray co-crystal structures are utilized to optimize the potency of an HTS hit to a spiroindoline pyrrolopyrimidine. The synthesis and SAR of multiple…”
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Design, Synthesis, and Activity of 2-Imidazol-1-ylpyrimidine Derived Inducible Nitric Oxide Synthase Dimerization Inhibitors by Davey, David D, Adler, Marc, Arnaiz, Damian, Eagen, Keith, Erickson, Shawn, Guilford, William, Kenrick, Margaret, Morrissey, Michael M, Ohlmeyer, Mike, Pan, Gonghua, Paradkar, Vidyadhar M, Parkinson, John, Polokoff, Mark, Saionz, Kurt, Santos, Cecile, Subramanyam, Babu, Vergona, Ron, Wei, Robert G, Whitlow, Marc, Ye, Bin, Zhao, Zuchun (Spring), Devlin, James J, Phillips, Gary

“…By the screening of a combinatorial library for inhibitors of nitric oxide (NO) formation by the inducible isoform of nitric oxide synthase (iNOS) using a…”
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Underestimated disease prevalence and severe phenotypes in patients with biallelic variants: A cohort study of primary familial brain calcification from China by Chen, Si, Cen, Zhidong, Fu, Feng, Chen, You, Chen, Xinhui, Yang, Dehao, Wang, Haotian, Wu, Hongwei, Zheng, Xiaosheng, Xie, Fei, Ouyang, Zhiyuan, Tang, Weiguo, Zhang, Shuhong, Yin, Lili, Zhang, Yunqian, Meng, Peiying, Zhu, Xuzhen, Zhang, Hongwei, Jiang, Feifei, Zhang, Kaiyu, He, Juping, Zhang, Danhong, Ming, Hanqiao, Song, Daqiao, Zhou, Zhiping, Luo, Yong, Gu, Qun, Su, Yongkun, Wu, Xinxiao, Tang, Haiyan, Wu, Chenglong, Chen, Weiqing, Liu, Jing-Yu, Luo, Wei, Huang, Xuerong, Fu, Shaowei, Chen, Wenhai, Huang, Yanbin, Lan, Likang, Zhu, Xiaofen, Xu, Zhijun, Huang, Huayun, Zhou, Lifeng, Chen, Zilong, Lou, Minfang, Wang, Binglan, Tan, Yi, Zhu, Manlian, Hong, Weijun, Wang, Feng, Pan, Gonghua, Shao, Aimin, Li, Weiying, Li, Haijun, Zhao, Na, Hu, Haoyu, Zhang, Yaxi, Lian, Mengjia, Li, Jieying, Cai, Xueli, Luo, Zixian, Zhou, Yan, Lu, Xiaoyi, Ma, Li, Xia, Enkui, Zhang, Xiaoluo

“…Primary familial brain calcification (PFBC) is a rare calcifying disorder of the brain with extensive clinical and genetic heterogeneity. Its prevalence is…”
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Evaluation of a Multilevel Program to Improve Clinician Adherence to Management Guidelines for Acute Ischemic Stroke by Chen, Yi, Gong, Xiaoxian, Zhong, Wansi, Wang, Jianbing, Yang, Zongming, Yan, Shenqiang, Geng, Fangli, Zhou, Ying, Zhang, Xuting, Chen, Zhicai, Hu, Haitao, Tong, Lusha, Chen, Hongfang, Ke, Shaofa, He, Yuping, Wang, Yaxian, Zhang, Xiaoling, Wang, Zhimin, Chen, Zhihui, Zhao, Heng, Yuan, Changzheng, Lou, Min

“…Promotion of clinician adherence to stroke guidelines can improve stroke outcomes. To investigate the outcomes of a multilevel system program on clinician…”
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Allosteric Inhibitors of Inducible Nitric Oxide Synthase Dimerization Discovered via Combinatorial Chemistry by McMillan, Kirk, Adler, Marc, Auld, Douglas S., Baldwin, John J., Blasko, Eric, Browne, Leslie J., Chelsky, Daniel, Davey, David, Dolle, Ronald E., Eagen, Keith A., Erickson, Shawn, Feldman, Richard I., Glaser, Charles B., Mallari, Cornell, Morrissey, Michael M., Michael H. J. Ohlmeyer, Pan, Gonghua, Parkinson, John F., Phillips, Gary B., Polokoff, Mark A., Sigal, Nolan H., Vergona, Ronald, Whitlow, Marc, Young, Tish A., Devlin, James J.

“…Potent and selective inhibitors of inducible nitric oxide synthase (iNOS) (EC 1.14.13.39) were identified in an encoded combinatorial chemical library that…”
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Small molecule antagonists of the bradykinin B1 receptor by Horlick, Robert A, Ohlmeyer, Michael H, Stroke, Ilana L, Strohl, Barbara, Pan, Gonghua, Schilling, Adriane E, Paradkar, Vidyadhar, Quintero, Jorge G, You, Ming, Riviello, Christopher, Thorn, Megan B, Damaj, Bassam, Fitzpatrick, V.Danial, Dolle, Roland E, Webb, Maria L, Baldwin, John J, Sigal, Nolan H

“…Screening Pharmacopeia's encoded combinatorial libraries has led to the identification of potent, selective, competitive antagonists at the bradykinin B1…”
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