Search Results - "Pan, Daniel C."

Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude by Brenner, Jacob S., Pan, Daniel C., Myerson, Jacob W., Marcos-Contreras, Oscar A., Villa, Carlos H., Patel, Priyal, Hekierski, Hugh, Chatterjee, Shampa, Tao, Jian-Qin, Parhiz, Hamideh, Bhamidipati, Kartik, Uhler, Thomas G., Hood, Elizabeth D., Kiseleva, Raisa Yu, Shuvaev, Vladimir S., Shuvaeva, Tea, Khoshnejad, Makan, Johnston, Ian, Gregory, Jason V., Lahann, Joerg, Wang, Tao, Cantu, Edward, Armstead, William M., Mitragotri, Samir, Muzykantov, Vladimir

“…Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition, even when NCs are targeted using…”
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Oral delivery of sorafenib through spontaneous formation of ionic liquid nanocomplexes by Shi, Yujie, Zhao, Zongmin, Gao, Yongsheng, Pan, Daniel C., Salinas, Alyssa K., Tanner, Eden E.L., Guo, Junling, Mitragotri, Samir

“…Delivery of hydrophobic drugs is a significant challenge due to poor solubility and formulation difficulty. Here, we describe the potential of ionic liquids,…”
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Cellular backpacks for macrophage immunotherapy by Shields, 4th, C Wyatt, Evans, Michael A, Wang, Lily Li-Wen, Baugh, Neil, Iyer, Siddharth, Wu, Debra, Zhao, Zongmin, Pusuluri, Anusha, Ukidve, Anvay, Pan, Daniel C, Mitragotri, Samir

“…Adoptive cell transfers have emerged as a disruptive approach to treat disease in a manner that is more specific than using small-molecule drugs; however,…”
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A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens by Weyant, Kevin B., Oloyede, Ayomide, Pal, Sukumar, Liao, Julie, Jesus, Mariela Rivera-De, Jaroentomeechai, Thapakorn, Moeller, Tyler D., Hoang-Phou, Steven, Gilmore, Sean F., Singh, Riya, Pan, Daniel C., Putnam, David, Locher, Christopher, de la Maza, Luis M., Coleman, Matthew A., DeLisa, Matthew P.

“…Engineered outer membrane vesicles (OMVs) derived from Gram-negative bacteria are a promising technology for the creation of non-infectious, nanoparticle…”
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Hyaluronic acid–doxorubicin nanoparticles for targeted treatment of colorectal cancer by Pan, Daniel C., Krishnan, Vinu, Salinas, Alyssa K., Kim, Jayoung, Sun, Tao, Ravid, Sagi, Peng, Kevin, Wu, Debra, Nurunnabi, Md, Nelson, Jeffery A., Niziolek, Zachary, Guo, Junling, Mitragotri, Samir

“…Colorectal cancer, common in both men and women, occurs when tumors form in the linings of the colon. Common treatments of colorectal cancer include surgery,…”
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Ultrasound‐mediated delivery of flexibility‐tunable polymer drug conjugates for treating glioblastoma by Sun, Tao, Krishnan, Vinu, Pan, Daniel C., Filippov, Sergey K., Ravid, Sagi, Sarode, Apoorva, Kim, Jayoung, Zhang, Yongzhi, Power, Chanikarn, Aday, Sezin, Guo, Junling, Karp, Jeffrey M., McDannold, Nathan J., Mitragotri, Samir S.

“…Effective chemotherapy delivery for glioblastoma multiforme (GBM) is limited by drug transport across the blood–brain barrier and poor efficacy of single…”
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Biocompatible coupling of therapeutic fusion proteins to human erythrocytes by Villa, Carlos H., Pan, Daniel C., Johnston, Ian H., Greineder, Colin F., Walsh, Landis R., Hood, Elizabeth D., Cines, Douglas B., Poncz, Mortimer, Siegel, Don L., Muzykantov, Vladimir R.

“…Carriage of drugs by red blood cells (RBCs) modulates pharmacokinetics, pharmacodynamics, and immunogenicity. However, optimal targets for attaching…”
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Erythrocyte-driven immunization via biomimicry of their natural antigen-presenting function by Ukidve, Anvay, Zhao, Zongmin, Fehnel, Alexandra, Krishnan, Vinu, Pan, Daniel C., Gao, Yongsheng, Mandal, Abhirup, Muzykantov, Vladimir, Mitragotri, Samir

“…Erythrocytes naturally capture certain bacterial pathogens in circulation, kill them through oxidative stress, and present them to the antigen-presenting cells…”
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Imiquimod-gemcitabine nanoparticles harness immune cells to suppress breast cancer by Singh, Bijay, Maharjan, Sushila, Pan, Daniel C., Zhao, Zongmin, Gao, Yongsheng, Zhang, Yu Shrike, Mitragotri, Samir

“…Monotherapy with a single chemotherapeutic regimen has met with significant hurdles in terms of clinical efficacy. The complexity of cancer accentuates the…”
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Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells by Pan, Daniel C., Myerson, Jacob W., Brenner, Jacob S., Patel, Priyal N., Anselmo, Aaron C., Mitragotri, Samir, Muzykantov, Vladimir

“…Attachment of nanoparticles (NPs) to the surface of carrier red blood cells (RBCs) profoundly alters their interactions with the host organism, decelerating NP…”
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Engineering of Living Cells with Polyphenol‐Functionalized Biologically Active Nanocomplexes by Zhao, Zongmin, Pan, Daniel C., Qi, Qin M., Kim, Jayoung, Kapate, Neha, Sun, Tao, Shields, C. Wyatt, Wang, Lily Li‐Wen, Wu, Debra, Kwon, Christopher J., He, Wei, Guo, Junling, Mitragotri, Samir

“…Approaches to safely and effectively augment cellular functions without compromising the inherent biological properties of the cells, especially through the…”
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A dual macrophage polarizer conjugate for synergistic melanoma therapy by Sallam, Marwa A., Wyatt Shields IV, C., Prakash, Supriya, Kim, Jayoung, Pan, Daniel C., Mitragotri, Samir

“…Tumor associated macrophages (TAMs) play a paradoxical role in the fate of aggressive tumors like melanoma. Immune modulation of TAMs from the tumor-permissive…”
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Systemic tumour suppression via the preferential accumulation of erythrocyte-anchored chemokine-encapsulating nanoparticles in lung metastases by Zhao, Zongmin, Ukidve, Anvay, Krishnan, Vinu, Fehnel, Alexandra, Pan, Daniel C., Gao, Yongsheng, Kim, Jayoung, Evans, Michael A., Mandal, Abhirup, Guo, Junling, Muzykantov, Vladimir R., Mitragotri, Samir

“…Eliciting immune responses against primary tumours is hampered by their immunosuppressive microenvironment and by the greater inaccessibility of deeper…”
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Ferritin Nanocages with Biologically Orthogonal Conjugation for Vascular Targeting and Imaging by Khoshnejad, Makan, Greineder, Colin F, Pulsipher, Katherine W, Villa, Carlos H, Altun, Burcin, Pan, Daniel C, Tsourkas, Andrew, Dmochowski, Ivan J, Muzykantov, Vladimir R

“…Genetic incorporation of biologically orthogonal functional groups into macromolecules has the potential to yield efficient, controlled, reproducible,…”
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Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier by Villa, Carlos H, Pan, Daniel C, Zaitsev, Sergei, Cines, Douglas B, Siegel, Donald L, Muzykantov, Vladimir R

“…For several decades, researchers have used erythrocytes for drug delivery of a wide variety of therapeutics in order to improve their pharmacokinetics,…”
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Mechanisms that determine nanocarrier targeting to healthy versus inflamed lung regions by Brenner, Jacob S, Bhamidipati, Kartik, Glassman, Patrick, Ramakrishnan, N, Jiang, Depeng, Paris, Andrew J, Myerson, Jacob W, Pan, Daniel C, Shuvaev, Vladimir V, Villa, Carlos, Hood, Elizabeth D, Kiseleva, Raisa, Greineder, Colin F, Radhakrishnan, Ravi, Muzykantov, Vladimir R

“…Abstract Inflamed organs display marked spatial heterogeneity of inflammation, with patches of inflamed tissue adjacent to healthy tissue. To investigate how…”
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Dual targeting of therapeutics to endothelial cells: collaborative enhancement of delivery and effect by Greineder, Colin F., Brenza, Jacob B., Carnemolla, Ronald, Zaitsev, Sergei, Hood, Elizabeth D., Pan, Daniel C., Ding, Bi‐Sen, Esmon, Charles T., Chacko, Ann Marie, Muzykantov, Vladimir R.

“…Anchoring pharmacologic agents to the vascular lumen has the potential to modulate critical processes at the blood‐tissue interface, avoiding many of the…”
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Long-circulating Janus nanoparticles made by electrohydrodynamic co-jetting for systemic drug delivery applications by Rahmani, Sahar, Villa, Carlos H., Dishman, Acacia F., Grabowski, Marika E., Pan, Daniel C., Durmaz, Hakan, Misra, Asish C, Colón-Meléndez, Laura, Solomon, Michael J., Muzykantov, Vladimir R., Lahann, Joerg

“…Background: Nanoparticles with controlled physical properties have been widely used for controlled release applications. In addition to shape, the anisotropic…”
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Hyaluronic a cid–doxorubicin nanoparticles for targeted treatment of colorectal cancer by Pan, Daniel C., Krishnan, Vinu, Salinas, Alyssa K., Kim, Jayoung, Sun, Tao, Ravid, Sagi, Peng, Kevin, Wu, Debra, Nurunnabi, Md, Nelson, Jeffery A., Niziolek, Zachary, Guo, Junling, Mitragotri, Samir

“…Abstract Colorectal cancer, common in both men and women, occurs when tumors form in the linings of the colon. Common treatments of colorectal cancer include…”
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