Search Results - "Paluru, Prasuna"

Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines by Mills, Jason A., Wang, Kai, Paluru, Prasuna, Ying, Lei, Lu, Lin, Galvão, Aline M., Xu, Dongbin, Yao, Yu, Sullivan, Spencer K., Sullivan, Lisa M., Mac, Helen, Omari, Amel, Jean, Jyh-Chang, Shen, Steve, Gower, Adam, Spira, Avi, Mostoslavsky, Gustavo, Kotton, Darrell N., French, Deborah L., Weiss, Mitchell J., Gadue, Paul

“…Induced pluripotent stem cells (iPSCs) hold great promise for modeling human hematopoietic diseases. However, intrinsic variability in the capacities of…”
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Hematopoietic differentiation of pluripotent stem cells in culture by Mills, Jason A, Paluru, Prasuna, Weiss, Mitchell J, Gadue, Paul, French, Deborah L

“…This chapter describes a two-dimensional "monolayer" system for differentiating human pluripotent stem cells (PSCs) into "primitive" hematopoietic progenitor…”
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The phenotypic spectrum of ZIC3 mutations includes isolated d-transposition of the great arteries and double outlet right ventricle by D'Alessandro, Lisa C.A., Latney, Brande C., Paluru, Prasuna C., Goldmuntz, Elizabeth

“…Disease causing mutations for heterotaxy syndrome were first identified in the X‐linked laterality gene, ZIC3. Mutations typically result in males with situs…”
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Identification of a Novel Locus on 2q for Autosomal Dominant High-Grade Myopia by Paluru, Prasuna C, Nallasamy, Sudha, Devoto, Marcella, Rappaport, Eric F, Young, Terri L

“…Myopia, or nearsightedness, is a visual disorder of high and growing prevalence in the United States and in other countries. Pathologic high myopia, or myopia…”
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Genetic linkage study of high-grade myopia in a Hutterite population from South Dakota by Nallasamy, Sudha, Paluru, Prasuna C, Devoto, Marcella, Wasserman, Nora F, Zhou, Jie, Young, Terri L

“…Myopia is a common, complex disorder, and severe forms have implications for blindness due to increased risk of premature cataracts, glaucoma, retinal…”
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The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells by Paluru, Prasuna, Hudock, Kristin M., Cheng, Xin, Mills, Jason A., Ying, Lei, Galvão, Aline M., Lu, Lin, Tiyaboonchai, Amita, Sim, Xiuli, Sullivan, Spencer K., French, Deborah L., Gadue, Paul

“…The Wnt gene family consists of structurally related genes encoding secreted signaling molecules that have been implicated in many developmental processes,…”
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Sequence variants in the transforming growth β-induced factor (TGIF) gene are not associated with high myopia by SCAVELLO, Genaro S, PALURU, Prasuna C, GANTER, William R, YOUNG, Terri L

“…High myopia is a common complex-trait eye disorder, with implications for blindness due to increased risk of retinal detachment, macular degeneration,…”
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Exclusion of lumican and fibromodulin as candidate genes in MYP3 linked high grade myopia by Paluru, Prasuna C, Scavello, Genaro S, Ganter, William R, Young, Terri L

“…The proteoglycans lumican and fibromodulin regulate collagen fibril assembly and show expression in ocular tissues. A recent mouse knockout study implicates…”
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Microarray analysis of gene expression in human donor sclera by Young, Terri L, Scavello, Genaro S, Paluru, Prasuna C, Choi, Jonathan D, Rappaport, Eric F, Rada, Jody A

“…To develop gene expression profiles of human sclera to allow for the identification of novel, uncharacterized genes in this tissue-type, and to identify…”
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Genomic structure and organization of the high grade Myopia-2 locus (MYP2) critical region: mutation screening of 9 positional candidate genes by Scavello, Jr, Genaro S, Paluru, Prasuna C, Zhou, Jie, White, Peter S, Rappaport, Eric F, Young, Terri L

“…Myopia is a common complex eye disorder, with implications for blindness due to increased risk of retinal detachment, chorioretinal degeneration, premature…”
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Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia by Gandre-Babbe, Shilpa, Paluru, Prasuna, Aribeana, Chiaka, Chou, Stella T., Bresolin, Silvia, Lu, Lin, Sullivan, Spencer K., Tasian, Sarah K., Weng, Julie, Favre, Helene, Choi, John K., French, Deborah L., Loh, Mignon L., Weiss, Mitchell J.

“…Juvenile myelomonocytic leukemia (JMML) is an aggressive myeloproliferative neoplasm of young children initiated by mutations that deregulate cytokine receptor…”
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MicroRNA Screen of Human Embryonic Stem Cell Differentiation Reveals miR‐105 as an Enhancer of Megakaryopoiesis from Adult CD34+ Cells by Kamat, Viraj, Paluru, Prasuna, Myint, Melissa, French, Deborah L., Gadue, Paul, Diamond, Scott L.

“…MicroRNAs (miRNAs) can control stem cell differentiation by targeting mRNAs. Using 96‐well plate electroporation, we screened 466 human miRNA mimics by…”
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X-linked high myopia associated with cone dysfunction by Young, Terri L, Deeb, Samir S, Ronan, Shawn M, Dewan, Andrew T, Alvear, Alison B, Scavello, Genaro S, Paluru, Prasuna C, Brott, Marcia S, Hayashi, Takaaki, Holleschau, Ann M, Benegas, Nancy, Schwartz, Marianne, Atwood, Larry D, Oetting, William S, Rosenberg, Thomas, Motulsky, Arno G, King, Richard A

“…Bornholm eye disease (BED) consists of X-linked high myopia, high cylinder, optic nerve hypoplasia, reduced electroretinographic flicker with abnormal photopic…”
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High-level transgene expression in induced pluripotent stem cell–derived megakaryocytes: correction of Glanzmann thrombasthenia by Sullivan, Spencer K., Mills, Jason A., Koukouritaki, Sevasti B., Vo, Karen K., Lyde, Randolph B., Paluru, Prasuna, Zhao, Guoha, Zhai, Li, Sullivan, Lisa M., Wang, Yuhuan, Kishore, Siddharth, Gharaibeh, Eyad Z., Lambert, Michele P., Wilcox, David A., French, Deborah L., Poncz, Mortimer, Gadue, Paul

“…Megakaryocyte-specific transgene expression in patient-derived induced pluripotent stem cells (iPSCs) offers a new approach to study and potentially treat…”
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Mutations in NTRK3 Suggest a Novel Signaling Pathway in Human Congenital Heart Disease by Werner, Petra, Paluru, Prasuna, Simpson, Anisha M., Latney, Brande, Iyer, Radhika, Brodeur, Garrett M., Goldmuntz, Elizabeth

“…ABSTRACT Congenital heart defects (CHDs) are the most common major birth defects and the leading cause of death from congenital malformations. The etiology…”
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Microdeletions and microduplications in patients with congenital heart disease and multiple congenital anomalies by Goldmuntz, Elizabeth, Paluru, Prasuna, Glessner, Joseph, Hakonarson, Hakon, Biegel, Jaclyn A, White, Peter S, Gai, Xiaowu, Shaikh, Tamim H

“…Multiple genetic syndromes are caused by recurrent chromosomal microdeletions or microduplications. The increasing use of high-resolution microarrays in…”
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Insights Into Thrombopoiesis From Infused Human Megakaryocytes Into Mice by Wang, Yuhuan, Hayes, Vincent M., Paluru, Prasuna, Chou, Stella T., French, Deborah L., Poncz, Mortimer

“…Thrombopoiesis is the process by which megakaryocytes (Megs) release platelets (Plts), but issues remain as to the detailed in vivo mechanisms underlying this…”
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Abstract 17979: A Subset of Patients with Isolated Transposition of the Great Arteries and Double Outlet Right Ventricle Fall Within the Spectrum of Heterotaxy Syndrome by D'Alessandro, Lisa C, Latney, Brande C, Paluru, Prasuna C, Goldmuntz, Elizabeth

“…Abstract only Background: Heterotaxy is a rare disorder of laterality. ZIC3 was the first gene in which human disease-causing mutations were identified…”
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Refinement of the X-linked nonsyndromic high-grade myopia locus MYP1 on Xq28 and exclusion of 13 known positional candidate genes by direct sequencing by Ratnamala, Uppala, Lyle, Robert, Rawal, Rakesh, Singh, Raminder, Vishnupriya, Satti, Himabindu, Pamini, Rao, Vittal, Aggarwal, Somesh, Paluru, Prasuna, Bartoloni, Lucia, Young, Terri L, Paoloni-Giacobino, Ariane, Morris, Michael A, Nath, Swapan K, Antonarakis, Stylianos E, Radhakrishna, Uppala

“…Myopia is a common vision problem affecting almost one third of the world's population. It can occur as an isolated genetic condition or be associated with…”
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New Locus for Autosomal Dominant High Myopia Maps to the Long Arm of Chromosome 17 by Paluru, Prasuna, Ronan, Shawn M, Heon, Elise, Devoto, Marcella, Wildenberg, Scott C, Scavello, Genaro, Holleschau, Ann, Makitie, Outi, Cole, William G, King, Richard A, Young, Terri L

“…To map the gene(s) associated with autosomal dominant (AD) high-grade myopia. A multigeneration English/Canadian family with AD severe myopia was ascertained…”
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