Search Results - "Paluh, Janet L."

Co-development of central and peripheral neurons with trunk mesendoderm in human elongating multi-lineage organized gastruloids by Olmsted, Zachary T., Paluh, Janet L.

“…Stem cell technologies including self-assembling 3D tissue models provide access to early human neurodevelopment and fundamental insights into…”
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A combined human gastruloid model of cardiogenesis and neurogenesis by Olmsted, Zachary T., Paluh, Janet L.

“…Multi-lineage development from gastruloids is enabling unprecedented opportunities to model and study human embryonic processes and is expected to accelerate…”
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Stem Cell Neurodevelopmental Solutions for Restorative Treatments of the Human Trunk and Spine by Olmsted, Zachary T, Paluh, Janet L

“…The ability to reliably repair spinal cord injuries (SCI) will be one of the greatest human achievements realized in regenerative medicine. Until recently, the…”
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Editorial: Bridging the gap: implementing building blocks of the nervous system to simulate neuronal functions at different levels by Watanabe, Yasuhito, Sakaguchi, Yutaka, Paluh, Janet L

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Corrigendum: Axonal transport during injury on a theoretical axon by Chandra, Soumyadeep, Chatterjee, Rounak, Olmsted, Zachary T, Mukherjee, Amitava, Paluh, Janet L

“…[This corrects the article DOI: 10.3389/fncel.2023.1215945.]…”
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SyNC, a Computationally Extensive and Realistic Neural Net to Identify Relative Impacts of Synaptopathy Mechanisms on Glutamatergic Neurons and Their Networks in Autism and Complex Neurological Disorders by Chatterjee, Rounak, Paluh, Janet L., Chowdhury, Souradeep, Mondal, Soham, Raha, Arnab, Mukherjee, Amitava

“…Synaptic function and experience-dependent plasticity across multiple synapses are dependent on the types of neurons interacting as well as the intricate…”
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Axonal transport during injury on a theoretical axon by Chandra, Soumyadeep, Chatterjee, Rounak, Olmsted, Zachary T, Mukherjee, Amitava, Paluh, Janet L

“…Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of…”
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Fully Characterized Mature Human iPS- and NMP-Derived Motor Neurons Thrive Without Neuroprotection in the Spinal Contusion Cavity by Olmsted, Zachary T, Stigliano, Cinzia, Marzullo, Brandon, Cibelli, Jose, Horner, Philip J, Paluh, Janet L

“…Neural cell interventions in spinal cord injury (SCI) have focused predominantly on transplanted multipotent neural stem/progenitor cells (NSPCs) for animal…”
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Generation of human elongating multi-lineage organized cardiac gastruloids by Olmsted, Zachary T., Paredes-Espinosa, Maria Belen, Paluh, Janet L.

“…Human elongating multi-lineage organized (EMLOC) gastruloid technology captures key aspects of trunk neurodevelopment including neural integration with…”
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Transplantable human motor networks as a neuron-directed strategy for spinal cord injury by Olmsted, Zachary T., Stigliano, Cinzia, Scimemi, Annalisa, Wolfe, Tatiana, Cibelli, Jose, Horner, Philip J., Paluh, Janet L.

“…To repair neural circuitry following spinal cord injury (SCI), neural stem cell (NSC) transplantation has held a primary focus; however, stochastic outcomes…”
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Human stem cell–derived neurons and neural circuitry therapeutics: Next frontier in spinal cord injury repair by Paredes-Espinosa, Maria Belen, Paluh, Janet L

“…Spinal cord injury (SCI) remains a life-altering event that devastates those injured and the families that support them. Numerous laboratories are engaged in…”
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Embryonic Spinal Cord Innervation in Human Trunk Organogenesis Gastruloids: Cardiac Versus Enteric Customization and Beyond by Olmsted, Zachary T, Paredes-Espinosa, Maria Belen, Paluh, Janet L

“…Trunk-biased human gastruloids provide the ability to couple developmentally relevant spinal neurogenesis and organ morphogenesis via spatiotemporal…”
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Distinct Kinesin-14 mitotic mechanisms in spindle bipolarity by Simeonov, Dimitre R., Kenny, Katelyn, Seo, Lan, Moyer, Amanda, Allen, Jessica, Paluh, Janet L.

“…Kinesin-like proteins are integral to formation and function of a conserved mitotic spindle apparatus that directs chromosome segregation and precedes cell…”
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Protein complexes at the microtubule organizing center regulate bipolar spindle assembly by Rodriguez, Adrianna S., Killilea, Alison N., Batac, Joseph, Filopei, Jason, Simeonov, Dimitre, Lin, Ida, Paluh, Janet L.

“…Bipolar spindle assembly is essential to genomic stability in dividing cells. Centrosomes or spindle pole bodies duplicated earlier at G1/S remain adjacent…”
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Insulin production from hiPSC‐derived pancreatic cells in a novel wicking matrix bioreactor by Amini, Nooshin, Paluh, Janet L., Xie, Yubing, Saxena, Vinit, Sharfstein, Susan T.

“…Clinical use of pancreatic β islets for regenerative medicine applications requires mass production of functional cells. Current technologies are insufficient…”
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An Extended Anaphase Signaling Pathway for Mad2p Includes Microtubule Organizing Center Proteins and Multiple Motor-dependent Transitions by Mayer, Christina, Filopei, Jason, Batac, Joe, Alford, Lea, Paluh, Janet L.

“…An Extended Anaphase Signaling Pathway for Mad2p Includes Microtubule Organizing Center Proteins and Multiple Motor-dependent TransitionsSignaling pathways…”
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Kinesin-14 and kinesin-5 antagonistically regulate microtubule nucleation by γ-TuRC in yeast and human cells by Olmsted, Zachary T., Colliver, Andrew G., Riehlman, Timothy D., Paluh, Janet L.

“…Bipolar spindle assembly is a critical control point for initiation of mitosis through nucleation and organization of spindle microtubules and is regulated by…”
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Fabrication of homotypic neural ribbons as a multiplex platform optimized for spinal cord delivery by Olmsted, Zachary T., Stigliano, Cinzia, Badri, Abinaya, Zhang, Fuming, Williams, Asher, Koffas, Mattheos A. G., Xie, Yubing, Linhardt, Robert J., Cibelli, Jose, Horner, Philip J., Paluh, Janet L.

“…Cell therapy for the injured spinal cord will rely on combined advances in human stem cell technologies and delivery strategies. Here we encapsulate homotypic…”
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Derivation of Ethnically Diverse Human Induced Pluripotent Stem Cell Lines by Chang, Eun Ah, Tomov, Martin L., Suhr, Steven T., Luo, Jiesi, Olmsted, Zachary T., Paluh, Janet L., Cibelli, Jose

“…The human genome with all its ethnic variations contributes to differences in human development, aging, disease, repair and response to medical treatments and…”
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Distinct and Shared Determinants of Cardiomyocyte Contractility in Multi-Lineage Competent Ethnically Diverse Human iPSCs by Tomov, Martin L., Olmsted, Zachary T., Dogan, Haluk, Gongorurler, Eda, Tsompana, Maria, Otu, Hasan H., Buck, Michael, Chang, Eun-Ah, Cibelli, Jose, Paluh, Janet L.

“…The realization of personalized medicine through human induced pluripotent stem cell (iPSC) technology can be advanced by transcriptomics, epigenomics, and…”
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