Hypovitaminosis D and secondary hyperparathyroidism in resident physicians of a general hospital in southern Brazil

Objectives : To evaluate the prevalence of hypovitaminosis D and secondary hyperparathyroidism in resident physicians of a general hospital in southern Brazil and identify associated factors. Design : Crosssectional study. Population: Resident physicians of Hospital de Clinicas de Porto Alegre, Port...

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Bibliographic Details
Published in:	Journal of endocrinological investigation Vol. 31; no. 11; pp. 991 - 995
Main Authors:	Orlandin Premaor, M., Paludo, P., Manica, D., Paludo, A. P., Rossatto, E. R., Scalco, R., Furlanetto, T. W.
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-11-2008
Subjects:	Adult Body Mass Index Brazil - epidemiology Calcium - blood Calcium - urine Calcium, Dietary - administration & dosage Cross-Sectional Studies Endocrinology Female Hospitals, General Humans Hyperparathyroidism, Secondary - epidemiology Internship and Residency Magnesium - blood Male Medicine Medicine & Public Health Metabolic Diseases Original Articles Parathyroid Hormone - blood Prevalence Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - epidemiology resident physicians secondary hyperparathyroidism Parathyroid hormone vitamin D vitamin D deficiency
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Summary:	Objectives : To evaluate the prevalence of hypovitaminosis D and secondary hyperparathyroidism in resident physicians of a general hospital in southern Brazil and identify associated factors. Design : Crosssectional study. Population: Resident physicians of Hospital de Clinicas de Porto Alegre, Porto Alegre, southern Brazil. Participants: Seventythree subjects age 26.4± 1.9. Measurements: Serum PTH, 25- hydroxyvitamin D [25(OH)D], total calcium, phosphorus, magnesium, creatinine, and alkaline phosphatase were measured. In addition calcium, creatinine, and magnesium were measured in urine. Fractional excretion of calcium and magnesium were calculated. Calcium intake was estimated by a food intake questionnaire. Results : Mean serum levels of 25(OH)D were 17.9± 8.0 ng/ml and 57.4% presented 25(OH)D below 20 ng/ml. Secondary hyperparathyroidism, defined as serum PTH ≥ 48 pg/ml and normal or low serum calcium, was identified in 39.7% of the individuals. Mean serum levels of magnesium were higher ( p =0.02) and the fractional excretion of calcium was lower ( p <0.001) in individuals with secondary hyperparathyroidism. Serum PTH levels were positively correlated with body mass index (r=0.33 and p =0.006) and serum magnesium levels (r=0.33 and p =0.02) and negatively correlated with serum 25(OH)D levels (r=− 0.33 and p =0.008), estimated calcium intake (r=− 0.25 and p =0.04), and fractional excretion of calcium (r=− 0.34 and p =0.009). Conclusion : Vitamin D deficiency and secondary hyperparathyroidism was very common in resident physicians. Therefore, measures to prevent this situation should be recommended.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0391-4097 1720-8386
DOI:	10.1007/BF03345637