Search Results - "Paludan, Soeren R"

Activation and regulation of DNA-driven immune responses by Paludan, Søren R

“…The innate immune system provides early defense against infections and also plays a key role in monitoring alterations of homeostasis in the body. DNA is…”
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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING by Holm, Christian K, Jensen, Søren B, Jakobsen, Martin R, Cheshenko, Natalia, Horan, Kristy A, Moeller, Hanne B, Gonzalez-Dosal, Regina, Rasmussen, Simon B, Christensen, Maria H, Yarovinsky, Timur O, Rixon, Frazer J, Herold, Betsy C, Fitzgerald, Katherine A, Paludan, Søren R

“…Fusion with the cell membrane is the earliest event in viral infection. Paludan and colleagues show that 'unscheduled' membrane-fusion events elicit an innate…”
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Recognition of herpesviruses by the innate immune system by Paludan, Søren R, Bowie, Andrew G, Horan, Kristy A, Fitzgerald, Katherine A

“…Key Points Herpesviruses are a large family of DNA viruses, eight of which can cause diseases in humans, particularly in children and immunocompromised…”
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Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection by Thomsen, Martin K., Nandakumar, Ramya, Stadler, Daniela, Malo, Antje, Valls, Roser Marin, Wang, Fan, Reinert, Line S., Dagnæs‐Hansen, Frederik, Hollensen, Anne Kruse, Mikkelsen, Jacob Giehm, Protzer, Ulrike, Paludan, Søren R.

“…Hepatitis B virus (HBV) is a major human pathogen, and about one third of the global population will be exposed to the virus in their lifetime. HBV infects…”
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Innate Antiviral Defenses Independent of Inducible IFNα/β Production by Paludan, Søren R

“…The type I interferons (IFNs) (IFNα and IFNβ) not only have potent antiviral activities, but also have pathological functions if produced at high levels or…”
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IFI16 is an innate immune sensor for intracellular DNA by Bowie, Andrew G, Unterholzner, Leonie, Keating, Sinead E, Baran, Marcin, Horan, Kristy A, Jensen, Søren B, Sharma, Shruti, Sirois, Cherilyn M, Jin, Tengchuan, Latz, Eicke, Xiao, T Sam, Fitzgerald, Katherine A, Paludan, Søren R

“…Foreign nucleic acids trigger innate immune sensors. Bowie and colleagues identify the PYHIN protein IFI16 as an innate duplex DNA sensor that triggers IFN-β…”
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IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication by Jakobsen, Martin R, Bak, Rasmus O, Andersen, Annika, Berg, Randi K, Jensen, Søren B, Tengchuan, Jin, Jin, Tengchuan, Laustsen, Anders, Hansen, Kathrine, Ostergaard, Lars, Fitzgerald, Katherine A, Xiao, T Sam, Mikkelsen, Jacob G, Mogensen, Trine H, Paludan, Søren R

“…Replication of lentiviruses generates different DNA forms, including RNA:DNA hybrids, ssDNA, and dsDNA. Nucleic acids stimulate innate immune responses, and…”
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Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses by WEBER, Friedemann, WAGNER, Valentina, RASMUSSEN, Simon B, HARTMANN, Rune, PALUDAN, Søren R

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Functional IRF3 deficiency in a patient with herpes simplex encephalitis by Andersen, Line Lykke, Mørk, Nanna, Reinert, Line S, Kofod-Olsen, Emil, Narita, Ryo, Jørgensen, Sofie E, Skipper, Kristian A, Höning, Klara, Gad, Hans Henrik, Østergaard, Lars, Ørntoft, Torben F, Hornung, Veit, Paludan, Søren R, Mikkelsen, Jacob Giehm, Fujita, Takashi, Christiansen, Mette, Hartmann, Rune, Mogensen, Trine H

“…Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interferon (IFN) production downstream of Toll-like receptor 3…”
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Viral evasion of DNA-stimulated innate immune responses by Christensen, Maria H, Paludan, Søren R

“…Cellular sensing of virus-derived nucleic acids is essential for early defenses against virus infections. In recent years, the discovery of DNA sensing…”
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TRAM is required for TLR2 endosomal signaling to type I IFN induction by Stack, Julianne, Doyle, Sarah L, Connolly, Dympna J, Reinert, Line S, O'Keeffe, Kate M, McLoughlin, Rachel M, Paludan, Søren R, Bowie, Andrew G

“…Detection of microbes by TLRs on the plasma membrane leads to the induction of proinflammatory cytokines such as TNF-α, via activation of NF-κB. Alternatively,…”
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Type III Interferon (IFN) Induces a Type I IFN-Like Response in a Restricted Subset of Cells through Signaling Pathways Involving both the Jak-STAT Pathway and the Mitogen-Activated Protein Kinases by Zhou, Zhangle, Hamming, Ole J, Ank, Nina, Paludan, Søren R, Nielsen, Anders L, Hartmann, Rune

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Lambda Interferon (IFN-λ), a Type III IFN, Is Induced by Viruses and IFNs and Displays Potent Antiviral Activity against Select Virus Infections In Vivo by ANK, Nina, WEST, Hans, BARTHOLDY, Christina, ERIKSSON, Kristina, THOMSEN, Allan R, PALUDAN, Søren R

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Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors by Horan, Kristy A, Hansen, Kathrine, Jakobsen, Martin R, Holm, Christian K, Søby, Stine, Unterholzner, Leonie, Thompson, Mikayla, West, John A, Iversen, Marie B, Rasmussen, Simon B, Ellermann-Eriksen, Svend, Kurt-Jones, Evelyn, Landolfo, Santo, Damania, Blossom, Melchjorsen, Jesper, Bowie, Andrew G, Fitzgerald, Katherine A, Paludan, Søren R

“…The innate immune system is important for control of infections, including herpesvirus infections. Intracellular DNA potently stimulates antiviral IFN…”
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An Important Role for Type III Interferon (IFN-{lambda}/IL-28) in TLR-Induced Antiviral Activity by Ank, Nina, Iversen, Marie B, Bartholdy, Christina, Staeheli, Peter, Hartmann, Rune, Jensen, Uffe B, Dagnaes-Hansen, Frederik, Thomsen, Allan R, Chen, Zhi, Haugen, Harald, Klucher, Kevin, Paludan, Soren R

“…Type III IFNs (IFN-lambda/IL-28/29) are cytokines with type I IFN-like antiviral activities, which remain poorly characterized. We herein show that most cell…”
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Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice by Weber, Christian, Koenen, Rory R, von Hundelshausen, Philipp, Nesmelova, Irina V, Zernecke, Alma, Liehn, Elisa A, Sarabi, Alisina, Kramp, Birgit K, Piccinini, Anna M, Paludan, Søren R, Kowalska, M Anna, Kungl, Andreas J, Hackeng, Tilman M, Mayo, Kevin H

“…Atherosclerosis is characterized by chronic inflammation of the arterial wall due to chemokine-driven mononuclear cell recruitment. Activated platelets can…”
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Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses by Mordstein, Markus, Kochs, Georg, Dumoutier, Laure, Renauld, Jean-Christophe, Paludan, Søren R, Klucher, Kevin, Staeheli, Peter

“…Virus-infected cells secrete a broad range of interferon (IFN) subtypes which in turn trigger the synthesis of antiviral factors that confer host resistance…”
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IFI16: At the interphase between innate DNA sensing and genome regulation by Jakobsen, Martin R, Paludan, Søren R

“…Abstract DNA carries the genetic code, and is also a potent stimulator of innate immune responses. IFI16 is a member of the family of PYHIN proteins and is…”
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Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection by Sun, Chenglong, Schattgen, Stefan A, Pisitkun, Prapaporn, Jorgensen, Joan P, Hilterbrand, Adam T, Wang, Lucas J, West, John A, Hansen, Kathrine, Horan, Kristy A, Jakobsen, Martin R, O'Hare, Peter, Adler, Heiko, Sun, Ren, Ploegh, Hidde L, Damania, Blossom, Upton, Jason W, Fitzgerald, Katherine A, Paludan, Søren R

“…Herpesviruses are DNA viruses harboring the capacity to establish lifelong latent-recurrent infections. There is limited knowledge about viruses targeting the…”
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Early Innate Recognition of Herpes Simplex Virus in Human Primary Macrophages Is Mediated via the MDA5/MAVS-Dependent and MDA5/MAVS/RNA Polymerase III-Independent Pathways by Melchjorsen, Jesper, Rintahaka, Johanna, Søby, Stine, Horan, Kristy A, Poltajainen, Alina, Østergaard, Lars, Paludan, Søren R, Matikainen, Sampsa

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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