Search Results - "Paludan, Søren Riis"

Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death by Reimer, Lasse, Vesterager, Louise Buur, Betzer, Cristine, Zheng, Jin, Nielsen, Lærke Dalsgaard, Kofoed, Rikke Hahn, Lassen, Louise Berkhoudt, Bølcho, Ulrik, Paludan, Søren Riis, Fog, Karina, Jensen, Poul Henning

“…Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy comprise a group of neurodegenerative diseases termed synucleinopathies…”
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The p38 MAPK regulates IL-24 expression by stabilization of the 3' UTR of IL-24 mRNA by Otkjaer, Kristian, Holtmann, Helmut, Kragstrup, Tue Wenzel, Paludan, Søren Riis, Johansen, Claus, Gaestel, Matthias, Kragballe, Knud, Iversen, Lars

“…IL-24 (melanoma differentiation-associated gene-7 (mda-7)), a member of the IL-10 cytokine family, possesses the properties of a classical cytokine as well as…”
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Differential Impact of Interferon Regulatory Factor 7 in Initiation of the Type I Interferon Response in the Lymphocytic Choriomeningitis Virus-Infected Central Nervous System versus the Periphery by CHRISTENSEN, Jeanette Erbo, FENGER, Christina, ISSAZADEH-NAVIKAS, Shohreh, KRUG, Anna, LILJESTRØM, Peter, GORIELY, Stanislas, PALUDAN, Søren Riis, FINSEN, Bente, CHRISTENSEN, Jan Pravsgaard, THOMSEN, Allan Randrup

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The heat shock protein 90 inhibitor RGRN-305 attenuates SARS-CoV-2 spike protein-induced inflammation in vitro but lacks effectiveness as COVID-19 treatment in mice by Ben Abdallah, Hakim, Marino, Giorgia, Idorn, Manja, S Reinert, Line, Bregnhøj, Anne, Paludan, Søren Riis, Johansen, Claus

“…The inhibition of heat shock protein 90 (HSP90), a molecular chaperone, has been proposed to be a potential novel treatment strategy for Coronavirus disease…”
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Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages by Andersen, Line Lykke, Huang, Yiqi, Urban, Christian, Oubraham, Lila, Winheim, Elena, Stafford, Che, Nagl, Dennis, O'Duill, Fionan, Ebert, Thomas, Engleitner, Thomas, Paludan, Søren Riis, Krug, Anne, Rad, Roland, Hornung, Veit, Pichlmair, Andreas

“…The immune system is in place to assist in ensuring tissue homeostasis, which can be easily perturbed by invading pathogens or nonpathogenic stressors causing…”
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An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication by Mauthe, Mario, Langereis, Martijn, Jung, Jennifer, Zhou, Xingdong, Jones, Alex, Omta, Wienand, Tooze, Sharon A, Stork, Björn, Paludan, Søren Riis, Ahola, Tero, Egan, Dave, Behrends, Christian, Mokry, Michal, de Haan, Cornelis, van Kuppeveld, Frank, Reggiori, Fulvio

“…Autophagy is a catabolic process regulated by the orchestrated action of the autophagy-related (ATG) proteins. Recent work indicates that some of the ATG…”
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First-in-human use of a modular capsid virus-like vaccine platform: an open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2 by Smit, Merel J, Sander, Adam F, Ariaans, Maud B P A, Fougeroux, Cyrielle, Heinzel, Constanze, Fendel, Rolf, Esen, Meral, Kremsner, Peter G, ter Heine, Rob, Wertheim, Heiman F, Idorn, Manja, Paludan, Søren Riis, Underwood, Alexander P, Binderup, Alekxander, Ramirez, Santseharay, Bukh, Jens, Soegaard, Max, Erdogan, Sayit M, Gustavsson, Tobias, Clemmensen, Stine, Theander, Thor G, Salanti, Ali, Hamborg, Mette, de Jongh, Willem A, McCall, Matthew B B, Nielsen, Morten A, Mordmüller, Benjamin G, Smit, Merel J, Sander, Adam F, Ariaans, Maud B P A, Fougeroux, Cyrielle, Heinzel, Constanze, Fendel, Rolf, Esen, Meral, Kremsner, Peter G, ter Heine, Rob, Wertheim, Heiman F, Idorn, Manja, Riis Paludan, Søren, Underwood, Alexander P, Binderup, Alekxander, Ramirez, Santseharay, Bukh, Jens, Soegaard, Max, Erdogan, Sayit M, Gustavsson, Tobias, Clemmensen, Stine, Theander, Thor G, Salanti, Ali, Hamborg, Mette, de Jongh, Willem A, McCall, Matthew B B, Nielsen, Morten A, Mordmüller, Benjamin G, Dagil, Robert, Goksøyr, Louise, Hulen, Thomas M, Janitzek, Christoph, Jensen, Daniel S, Justesen, Sune, Khalifé, Paul K, Kreidenweiss, Andrea, Lança, Telma, Lie-Andersen, Olivia, Teelen, Karina, Vidal-Calvo, Elena

“…Capsid virus-like particles (cVLP) have proven safe and immunogenic and can be a versatile platform to counter pandemics. We aimed to clinically test a modular…”
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HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0 by Hensel, Niko, Raker, Verena, Förthmann, Benjamin, Detering, Nora Tula, Kubinski, Sabrina, Buch, Anna, Katzilieris-Petras, Georgios, Spanier, Julia, Gudi, Viktoria, Wagenknecht, Sylvia, Kopfnagel, Verena, Werfel, Thomas Andreas, Stangel, Martin, Beineke, Andreas, Kalinke, Ulrich, Paludan, Søren Riis, Sodeik, Beate, Claus, Peter

“…Herpes simplex virus-1 (HSV-1) infections of the central nervous system (CNS) can result in HSV-1 encephalitis (HSE) which is characterized by severe brain…”
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Pattern recognition receptor responses in children with chronic hepatitis B virus infection by Heiberg, Ida Louise, Winther, Thilde Nordmann, Paludan, Søren Riis, Hogh, Birthe

“…Abstract Background Several studies have demonstrated that hepatitis B virus (HBV) affects the expression and function of Toll like receptors (TLRs), but data…”
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Corona's new coat: SARS-CoV-2 in Danish minks and implications for travel medicine by Larsen, Carsten Schade, Paludan, Søren Riis

“…[...]numerous symptomatic Danish travelers returning from Ischgl were neither tested nor put in quarantine. There are more than 180 SARS-CoV-2 vaccine…”
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Elucidating the function of STING in systemic lupus erythematosus through the STING Goldenticket mouse mutant by Vejvisithsakul, Pichpisith Pierre, Thumarat, Chisanu, Leelahavanichkul, Asada, Hirankan, Nattiya, Pisitkun, Trairak, Paludan, Soren Riis, Pisitkun, Prapaporn

“…The complexity of systemic lupus erythematosus (SLE) arises from intricate genetic and environmental interactions, with STING playing a pivotal role. This…”
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Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice by Ling, Sikai, Yang, Shiqi, Hu, Xinde, Yin, Di, Dai, Yao, Qian, Xiaoqing, Wang, Dawei, Pan, Xiaoyong, Hong, Jiaxu, Sun, Xiaodong, Yang, Hui, Paludan, Soren Riis, Cai, Yujia

“…Therapeutic genome editing requires effective and targeted delivery methods. The delivery of Cas9 mRNA using adeno-associated viruses has led to potent in vivo…”
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Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical Neurons by Bergström, Petra, Trybala, Edward, Eriksson, Charlotta E, Johansson, Maria, Satir, Tugce Munise, Widéhn, Sibylle, Fruhwürth, Stefanie, Michno, Wojciech, Nazir, Faisal Hayat, Hanrieder, Jörg, Paludan, Soren Riis, Agholme, Lotta, Zetterberg, Henrik, Bergström, Tomas

“…Herpes simplex virus 1 (HSV-1) and 2 (HSV-2) can infect the central nervous system (CNS) with dire consequences; in children and adults, HSV-1 may cause focal…”
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IFI16 is an innate immune sensor for intracellular DNA by Bowie, Andrew G, Unterholzner, Leonie, Keating, Sinead E, Baran, Marcin, Horan, Kristy A, Jensen, Søren B, Sharma, Shruti, Sirois, Cherilyn M, Jin, Tengchuan, Latz, Eicke, Xiao, T Sam, Fitzgerald, Katherine A, Paludan, Søren R

“…Foreign nucleic acids trigger innate immune sensors. Bowie and colleagues identify the PYHIN protein IFI16 as an innate duplex DNA sensor that triggers IFN-β…”
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Vaginal HSV-2 Infection and Tissue Analysis by Iversen, Marie Beck, Paludan, Søren Riis, Holm, Christian Kanstrup

“…The vaginal murine HSV-2 infection model is very useful in studying mucosal immunity against HSV-2 ( Overall , 1975 ; Renis , 1976 ; Parr and Parr, 2003)…”
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Abstract PR004: Spatial proteomics and transcriptomics reveal an altered immune cell landscape in bladder cancer patients unresponsive to BCG treatment by Strandgaard, Trine, Andreasen, Tine Ginnerup, Divita, Tessa Jane, Salminen, Liina, Houghton, Sean, Thorsen, Kasper, Nordentoft, Iver, Okulate, Iyinyeoluwa, Schmitz, Alexander, Paludan, Søren Riis, Sfakianos, John, Horowitz, Amir, Jensen, Jørgen Bjerggaard, Dyrskjøt, Lars

“…Abstract Introduction: Patients with high-risk non-muscle invasive bladder cancer (NMIBC) are recommended treatment with Bacillus Calmette-Guérin (BCG). The…”
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Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation by Guerra, J, Valadao, A-L, Vlachakis, D, Polak, K, Vila, I K, Taffoni, C, Prabakaran, T, Marriott, A S, Kaczmarek, R, Houel, A, Auzemery, B, Déjardin, S, Boudinot, P, Nawrot, B, Jones, N J, Paludan, S R, Kossida, S, Langevin, C, Laguette, N

“…Inflammation is an essential part of immunity against pathogens and tumors but can promote disease if not tightly regulated. Self and non-self-nucleic acids…”
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Toll-like receptors, a new way of treatment? by Pedersen, Claus Vinter Bødker, Østergaard, Lars J, Mogensen, Trine H, Paludan, Søren Riis, Bertelsen, Lone Skovbo

“…Toll-like receptors (TLRs) comprise a group of recently discovered receptors which are essential molecular structures in the activation of immunity. The…”
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