Search Results - "Palubinsky, Amy M"

Genomic Risk Factors Driving Immune-Mediated Delayed Drug Hypersensitivity Reactions by Li, Yueran, Deshpande, Pooja, Hertzman, Rebecca J, Palubinsky, Amy M, Gibson, Andrew, Phillips, Elizabeth J

“…Adverse drug reactions (ADRs) remain associated with significant mortality. Delayed hypersensitivity reactions (DHRs) that occur greater than 6 h following…”
Get full text

Assembly Dynamics and Stoichiometry of the Apoptosis Signal-regulating Kinase (ASK) Signalosome in Response to Electrophile Stress by Federspiel, Joel D., Codreanu, Simona G., Palubinsky, Amy M., Winland, Ama J., Betanzos, Carlos Morales, McLaughlin, BethAnn, Liebler, Daniel C.

“…Apoptosis signal-regulating kinase 1 (ASK1) is a key sensor kinase in the mitogen-activated protein kinase pathway that transduces cellular responses to…”
Get full text

Visual Genomics Analysis Studio as a Tool to Analyze Multiomic Data by Hertzman, Rebecca J, Deshpande, Pooja, Leary, Shay, Li, Yueran, Ram, Ramesh, Chopra, Abha, Cooper, Don, Watson, Mark, Palubinsky, Amy M, Mallal, Simon, Gibson, Andrew, Phillips, Elizabeth J

“…Type B adverse drug reactions (ADRs) are iatrogenic immune-mediated syndromes with mechanistic etiologies that remain incompletely understood. Some of the most…”
Get full text

Dynamic Phosphorylation of Apoptosis Signal Regulating Kinase 1 (ASK1) in Response to Oxidative and Electrophilic Stress by Morales Betanzos, Carlos, Federspiel, Joel D, Palubinsky, Amy M, McLaughlin, BethAnn, Liebler, Daniel C

“…Apoptosis signal-regulating kinase 1 (ASK1) is a critical cellular stress sensor that senses diverse reactive chemotypes and integrates these chemical signals…”
Get full text

Haploinsufficiency of the E3 ubiquitin ligase C-terminus of heat shock cognate 70 interacting protein (CHIP) produces specific behavioral impairments by McLaughlin, Bethann, Buendia, Matthew A, Saborido, Tommy P, Palubinsky, Amy M, Stankowski, Jeannette N, Stanwood, Gregg D

“…The multifunctional E3 ubiquitin ligase CHIP is an essential interacting partner of HSP70, which together promote the proteasomal degradation of client…”
Get full text

Alteration of isocitrate dehydrogenase following acute ischemic injury as a means to improve cellular energetic status in neuroadaptation by Grelli, Kimberly N, Palubinsky, Amy M, Kale, A Cozette, Lizama-Manibusan, Britney N, Stankowski, Jeannette N, Milne, Ginger L, Singer, Robert, McLaughlin, Bethann

“…The isocitrate dehydrogenase (IDH) enzymes were initially identified as essential components of the Krebs cycle. IDH mutations were thought to be incompatible…”
Get more information

Updates on the immunopathology and genomics of severe cutaneous adverse drug reactions by Gibson, Andrew, Deshpande, Pooja, Campbell, Chelsea N., Krantz, Matthew S., Mukherjee, Eric, Mockenhaupt, Maja, Pirmohamed, Munir, Palubinsky, Amy M., Phillips, Elizabeth J.

“…Severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome, toxic epidermal necrolysis (SJS/TEN), and drug reaction with eosinophilia and…”
Get full text

Immunopharmacogenomics: Mechanisms of HLA‐Associated Drug Reactions by Deshpande, Pooja, Hertzman, Rebecca J., Palubinsky, Amy M., Giles, Jason B., Karnes, Jason H., Gibson, Andrew, Phillips, Elizabeth J.

“…The human leukocyte antigen (HLA) system is the most polymorphic in the human genome that has been associated with protection and predisposition to a broad…”
Get full text

Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues by Lizama, Britney N., Palubinsky, Amy M., McLaughlin, BethAnn

“…E3 ligases are essential scaffold proteins, facilitating the transfer of ubiquitin from E2 enzymes to lysine residues of client proteins via isopeptide bonds…”
Get full text

Neuronal Preconditioning Requires the Mitophagic Activity of C-terminus of HSC70-Interacting Protein by Lizama, Britney N, Palubinsky, Amy M, Raveendran, Vineeth A, Moore, Annah M, Federspiel, Joel D, Codreanu, Simona G, Liebler, Daniel C, McLaughlin, BethAnn

“…C-terminus of HSC70-interacting protein (CHIP, ) is a ubiquitously expressed cytosolic E3-ubiquitin ligase. CHIP-deficient mice exhibit cardiovascular stress…”
Get full text

Practical Implementation of Genetics: New Concepts in Immunogenomics to Predict, Prevent, and Diagnose Drug Hypersensitivity by Deshpande, Pooja, Li, Yueran, Thorne, Michael, Palubinsky, Amy M., Phillips, Elizabeth J., Gibson, Andrew

“…Delayed drug hypersensitivities are CD8+ T cell–mediated reactions associated with up to 50% mortality. Human leukocyte antigen (HLA) alleles are known to…”
Get full text

Multiomic single-cell sequencing defines tissue-specific responses in Stevens-Johnson syndrome and toxic epidermal necrolysis by Gibson, Andrew, Ram, Ramesh, Gangula, Rama, Li, Yueran, Mukherjee, Eric, Palubinsky, Amy M., Campbell, Chelsea N., Thorne, Michael, Konvinse, Katherine C., Choshi, Phuti, Deshpande, Pooja, Pedretti, Sarah, Fear, Mark W., Wood, Fiona M., O’Neil, Richard T., Wanjalla, Celestine N., Kalams, Spyros A., Gaudieri, Silvana, Lehloenya, Rannakoe J., Bailin, Samuel S., Chopra, Abha, Trubiano, Jason A., Peter, Jonny G., Mallal, Simon A., Phillips, Elizabeth J.

“…Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is a rare but life-threatening cutaneous drug reaction mediated by human leukocyte antigen…”
Get full text

CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling by Palubinsky, Amy M, Stankowski, Jeannette N, Kale, Alixandra C, Codreanu, Simona G, Singer, Robert J, Liebler, Daniel C, Stanwood, Gregg D, McLaughlin, BethAnn

“…Determine the mechanism by which C-terminus of HSC70-interacting protein (CHIP) induction alters neuronal survival under conditions of mitochondrial stress…”
Get more information

The role of central nervous system development in late-onset neurodegenerative disorders by Palubinsky, Amy M, Martin, Jacob A, McLaughlin, Bethann

“…The human brain is dependent upon successfully maintaining ionic, energetic and redox homeostasis within exceptionally narrow margins for proper function. The…”
Get more information

Metabolic Multianalyte Microphysiometry Reveals Extracellular Acidosis is an Essential Mediator of Neuronal Preconditioning by McKenzie, Jennifer R, Palubinsky, Amy M, Brown, Jacquelynn E, McLaughlin, BethAnn, Cliffel, David E

“…Metabolic adaptation to stress is a crucial yet poorly understood phenomenon, particularly in the central nervous system (CNS). The ability to identify…”
Get full text

Abstract 019: T Cell Recognition Of Isolevuglandin-adducted Proteins In Hypertension Is Mhc Class 1-restricted by Bloodworth, Nathaniel C, Chen, Wei, Ruggeri Barbaro, Natalia R, Ao, Mingfang, Palubinsky, Amy M, O'Niel, Richard T, Phillips, Elizabeth J, Moretti, Rocco, Davies, Sean S, Mallal, Simon A, Meiler, Jens, Harrison, David G

“…Abstract only Introduction: Isolevuglandins (isoLGs) are peroxidized lipids that covalently bond lysine residues to modify self-antigens in hypertension. We…”
Get full text

Haploinsufficiency of the E3 Ubiquitin Ligase C-Terminus of Heat Shock Cognate 70 Interacting Protein by McLaughlin, BethAnn, Buendia, Matthew A, Saborido, Tommy P, Palubinsky, Amy M, Stankowski, Jeannette N, Stanwood, Gregg D

“…The multifunctional E3 ubiquitin ligase CHIP is an essential interacting partner of HSP70, which together promote the proteasomal degradation of client…”
Get full text