Search Results - "Pals, Steven T."

Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options by van Andel, Harmen, Kocemba, Kinga A., Spaargaren, Marcel, Pals, Steven T.

“…Aberrant activation of Wnt/β-catenin signaling plays a central role in the pathogenesis of a wide variety of malignancies and is typically caused by mutations…”
Get full text

The clinically active BTK inhibitor PCI-32765 targets B-cell receptor– and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia by de Rooij, Martin F.M., Kuil, Annemieke, Geest, Christian R., Eldering, Eric, Chang, Betty Y., Buggy, Joseph J., Pals, Steven T., Spaargaren, Marcel

“…Small-molecule drugs that target the B-cell antigen receptor (BCR) signalosome show clinical efficacy in the treatment of B-cell non-Hodgkin lymphoma. These…”
Get full text

Towards genomic-based prognostication and precision therapy for diffuse large B-cell lymphoma by Minderman, Marthe, Pals, Steven T

Get full text

A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe by Hovius, Joppe W R, MD, de Wever, Bob, MSc, Sohne, Maaike, MD, Brouwer, Matthijs C, MD, Coumou, Jeroen, MSc, Wagemakers, Alex, MD, Oei, Anneke, Knol, Henrike, Narasimhan, Sukanya, PhD, Hodiamont, Caspar J, MD, Jahfari, Setareh, MSc, Pals, Steven T, Prof, Horlings, Hugo M, MD, Fikrig, Erol, Prof, Sprong, Hein, PhD, van Oers, Marinus H J, Prof

“…[...]ELISA and Western blot did not show anti-GlpQ antibodies in blood and CSF. [...]we are grateful to Manoj Fonville and Paul Hengeveld for their outstanding…”
Get full text

MYD88 in the driver's seat of B-cell lymphomagenesis: from molecular mechanisms to clinical implications by de Groen, Ruben A L, Schrader, Anne M R, Kersten, Marie José, Pals, Steven T, Vermaat, Joost S P

“…More than 50 subtypes of B-cell non-Hodgkin lymphoma (B-NHL) are recognized in the most recent World Health Organization classification of 2016. The current…”
Get full text

Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients by de Sousa E Melo, Felipe, Colak, Selcuk, Buikhuisen, Joyce, Koster, Jan, Cameron, Kate, de Jong, Joan H., Tuynman, Jurriaan B., Prasetyanti, Pramudita R., Fessler, Evelyn, van den Bergh, Saskia P., Rodermond, Hans, Dekker, Evelien, van der Loos, Chris M., Pals, Steven T., van de Vijver, Marc J., Versteeg, Rogier, Richel, Dick J., Vermeulen, Louis, Medema, Jan Paul

“…Gene signatures derived from cancer stem cells (CSCs) predict tumor recurrence for many forms of cancer. Here, we derived a gene signature for colorectal CSCs…”
Get full text

Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency by Kuijpers, Taco W., MD, PhD, Tool, Anton T.J., PhD, van der Bijl, Ivo, de Boer, Martin, van Houdt, Michel, de Cuyper, Iris M, Roos, Dirk, PhD, van Alphen, Floris, van Leeuwen, Karin, Cambridge, Emma L, Arends, Mark J., MBChB(Hons), PhD, MRCPath, Dougan, Gordon, PhD, Clare, Simon, PhD, Ramirez-Solis, Ramiro, PhD, Pals, Steven T., MD, PhD, Adams, David J., PhD, Meijer, Alexander B., PhD, van den Berg, Timo K., PhD

“…Arp2/3 gene deletions result in embryonic lethality in the mouse.2 The genetic defects in the regulatory proteins for cytoskeletal rearrangements cause…”
Get full text

Tissue-specific expression of IgG receptors by human macrophages ex vivo by Bruggeman, Christine W, Houtzager, Julia, Dierdorp, Barbara, Kers, Jesper, Pals, Steven T, Lutter, René, van Gulik, Thomas, den Haan, Joke M M, van den Berg, Timo K, van Bruggen, Robin, Kuijpers, Taco W

“…Recently it was discovered that tissue-resident macrophages derive from embryonic precursors, not only from peripheral blood monocytes, and maintain themselves…”
Get full text

MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance by Joosten, Sander P.J., Mizutani, Tomohiro, Spaargaren, Marcel, Clevers, Hans, Pals, Steven T.

Get full text

A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways by de Rooij, Martin F. M., Thus, Yvonne J., Swier, Nathalie, Beijersbergen, Roderick L., Pals, Steven T., Spaargaren, Marcel

“…The clinical introduction of the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib, which targets B-cell antigen-receptor (BCR)-controlled integrin-mediated…”
Get full text

MYD88 mutations identify a molecular subgroup of diffuse large B-cell lymphoma with an unfavorable prognosis by Vermaat, Joost S, Somers, Sebastiaan F, de Wreede, Liesbeth C, Kraan, Willem, de Groen, Ruben A L, Schrader, Anne M R, Kerver, Emile D, Scheepstra, Cornelis G, Berenschot, Henriëtte, Deenik, Wendy, Wegman, Jurgen, Broers, Rianne, de Boer, Jan-Paul D, Nijland, Marcel, van Wezel, Tom, Veelken, Hendrik, Spaargaren, Marcel, Cleven, Arjen H, Kersten, Marie José, Pals, Steven T

“…The 2016 World Health Organization classification defines diffuse large B-cell lymphoma (DLBCL) subtypes based on Epstein-Barr virus (EBV) infection and…”
Get full text

Immune evasion in primary testicular and central nervous system lymphomas: HLA loss rather than 9p24.1/PD-L1/PD-L2 alterations by Minderman, Marthe, Amir, Avital, Kraan, Willem, Schilder-Tol, Esther J.M., Oud, Monique E.C.M., Scheepstra, Cornelis G., Noorduyn, Arnold L., Kluin, Philip M., Kersten, Marie José, Spaargaren, Marcel, Pals, Steven T.

Get full text

Inhibition of casein kinase 2 sensitizes mantle cell lymphoma to venetoclax through MCL-1 downregulation by Thus, Yvonne J, De Rooij, Martin F M, Swier, Nathalie, Beijersbergen, Roderick L, Guikema, Jeroen E J, Kersten, Marie-José, Eldering, Eric, Pals, Steven T, Kater, Arnon P, Spaargaren, Marcel

“…BCL-2 family proteins are frequently aberrantly expressed in mantle cell lymphoma (MCL). Recently, the BCL-2-specific inhibitor venetoclax has been approved by…”
Get full text

Heparan sulfate proteoglycans in the control of B cell development and the pathogenesis of multiple myeloma by Reijmers, Rogier M., Spaargaren, Marcel, Pals, Steven T.

“…Heparan sulfate proteoglycans (HSPGs) have essential functions during embryonic development and throughout postnatal life. To exert these functions, they…”
Get full text

The forkhead transcription factor FOXP1 represses human plasma cell differentiation by van Keimpema, Martine, Grüneberg, Leonie J., Mokry, Michal, van Boxtel, Ruben, van Zelm, Menno C., Coffer, Paul, Pals, Steven T., Spaargaren, Marcel

“…Expression of the forkhead transcription factor FOXP1 is essential for early B-cell development, whereas downregulation of FOXP1 at the germinal center (GC)…”
Get full text

Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome by Oud, Machteld M., Tuijnenburg, Paul, Hempel, Maja, van Vlies, Naomi, Ren, Zemin, Ferdinandusse, Sacha, Jansen, Machiel H., Santer, René, Johannsen, Jessika, Bacchelli, Chiara, Alders, Marielle, Li, Rui, Davies, Rosalind, Dupuis, Lucie, Cale, Catherine M., Wanders, Ronald J.A., Pals, Steven T., Ocaka, Louise, James, Chela, Müller, Ingo, Lehmberg, Kai, Strom, Tim, Engels, Hartmut, Williams, Hywel J., Beales, Phil, Roepman, Ronald, Dias, Patricia, Brunner, Han G., Cobben, Jan-Maarten, Hall, Christine, Hartley, Taila, Le Quesne Stabej, Polona, Mendoza-Londono, Roberto, Davies, E. Graham, de Sousa, Sérgio B., Lessel, Davor, Arts, Heleen H., Kuijpers, Taco W.

“…EXTL3 regulates the biosynthesis of heparan sulfate (HS), important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans…”
Get full text

High prevalence of the MYD88 L265P mutation in IgM anti-MAG paraprotein-associated peripheral neuropathy by Vos, Josephine Mathilde, Notermans, Nicolette C, D’Sa, Shirley, Lunn, Michael P, van der Pol, W Ludo, Kraan, Willem, Reilly, Mary M, Chalker, Jane, Gupta, Rajeev, Kersten, Marie-José, Pals, Steven T, Minnema, Monique C

Get full text

Lymphoma dissemination: the other face of lymphocyte homing by Pals, Steven T., de Gorter, David J.J., Spaargaren, Marcel

“…The orchestration of systemic immune responses is critically dependent on coordinated lymphocyte migration and recirculation. This “homing” guides lymphocytes…”
Get full text

The CXCL12gamma chemokine immobilized by heparan sulfate on stromal niche cells controls adhesion and mediates drug resistance in multiple myeloma by Ren, Zemin, Lantermans, Hildo, Kuil, Annemieke, Kraan, Willem, Arenzana-Seisdedos, Fernando, Kersten, Marie José, Spaargaren, Marcel, Pals, Steven T

“…The survival and proliferation of multiple myeloma (MM) cells in the bone marrow (BM) critically depend on interaction with stromal cells expressing the…”
Get full text

Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis by Zeilstra, Jurrit, Joosten, Sander P J, Dokter, Maarten, Verwiel, Eugène, Spaargaren, Marcel, Pals, Steven T

“…Mutation of the genes encoding the WNT signaling components adenomatous polyposis coli or beta-catenin plays a critical role in the initiation of colorectal…”
Get full text