Search Results - "Palop, J. A."

Selenium and clinical trials: new therapeutic evidence for multiple diseases by Sanmartin, C, Plano, D, Font, M, Palop, J A

“…The understanding of the essential role of selenium (Se) in human health has increased substantially in recent decades. Micronutrient deficiencies are very…”
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The quinoline imidoselenocarbamate EI201 blocks the AKT/mTOR pathway and targets cancer stem cells leading to a strong antitumor activity by Ibáñez, E, Agliano, A, Prior, C, Nguewa, P, Redrado, M, González-Zubeldia, I, Plano, D, Palop, J A, Sanmartín, C, Calvo, A

“…Methylimidoselenocarbamates have previously proven to display potent antitumor activities. In the present study we show that these compounds act as multikinase…”
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Innovative lead compounds and formulation strategies as newer kinetoplastid therapies by Espuelas, S, Plano, D, Nguewa, P, Font, M, Palop, J A, Irache, J M, Sanmartín, C

“…The protozoan diseases leishmaniasis, human African trypanosomiasis (HAT) and Chagas disease (CD) are responsible for substantial global morbidity and…”
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Kinase regulation by sulfur and selenium containing compounds by Sanmartín, Carmen, Plano, Daniel, Font, María, Palop, Juan Antonio

“…Kinases are enzymes that are involved in a wide-range of cellular targets such as cell proliferation, metabolism, survival and apoptosis. Aberrations in the…”
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Thermal stability and decomposition of pharmaceutical compounds by LIZARRAGA, Elena, ZABALETA, C, PALOP, J. A

“…Thermal analysis of fusion and decomposition processes were carried out on recently synthetized pharmaceutical compounds in order to establish thermal…”
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New 1-Aryl-3-(4-arylpiperazin-1-yl)propane Derivatives, with Dual Action at 5-HT1A Serotonin Receptors and Serotonin Transporter, as a New Class of Antidepressants by Martínez-Esparza, Javier, Oficialdegui, Ana-M, Pérez-Silanes, Silvia, Heras, Begoña, Orús, Lara, Palop, Juan-A, Lasheras, Berta, Roca, Joan, Mourelle, Marisa, Bosch, Ana, Del Castillo, Juan-C, Tordera, Rosa, Del Río, Joaquín, Monge, Antonio

“…In a search toward new and efficient antidepressants, 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives were designed, synthesized, and evaluated for 5-HT…”
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Hypoxia-Selective Agents Derived from Quinoxaline 1,4-Di-N-oxides by Monge, Antonio, Palop, Juan A, de Cerain, Adela Lopez, Senador, Virginia, Martinez, Francisco J, Sainz, Yolanda, Narro, Susana, Garcia, Estrella, de Miguel, Carlos

“…Hypoxic cells, which are a common feature of solid tumors, but not normal tissues, are resistant to both anticancer drugs and radiation therapy. Thus the…”
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Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives by Monge, A, Palop, J. A, Del Castillo, J. C, Caldero, J. M, Roca, J, Romero, G, Del Rio, J, Lasheras, B

“…A series of piperazinylquinoxalines has been synthesized and studied as 5-HT3 receptor antagonists in different preparations. Antagonism to 5-HT in the…”
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Strong induction of iodothyronine deiodinases by chemotherapeutic selenocompounds by Stoedter, M, Renko, K, Ibáñez, E, Plano, D, Becker, N-P, Martitz, J, Palop, J A, Calvo, A, Sanmartín, C, Schomburg, L

“…The biological activity of thyroid hormones (TH) is regulated by selenoenzymes of the iodothyronine deiodinase (DIO) family catalysing TH activating and…”
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Mechanism of thermal decomposition of thiourea derivatives by Lizarraga, Elena, Zabaleta, C., Palop, J. A.

“…The thermal decomposition of a series of compounds has been studied by thermogravimetry, mass spectrometry, nuclear magnetic resonance and elemental analysis…”
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Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism by OFICIALDEGUI, A. M, MARTINEZ, J, PEREZ, S, HERAS, B, IRURZUN, M, PALOP, J. A, TORDERA, R, LASHERAS, B, DEL RIO, J, MONGE, A

“…It has been suggested that the combination of a selective serotonin reuptake inhibitor (SSRI) and a 5-HT1A receptor antagonist may facilitate the onset of the…”
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Synthesis of 2-Piperazinylbenzothiazole and 2-Piperazinylbenzoxazole Derivatives with 5-HT3 Antagonist and 5-HT4 Agonist Properties by Monge, Antonio, Pena, Maria del Carmen, Palop, Juan Antonio, Caldero, Jose Maria, Roca, Juan, Garcia, Elisa, Romero, Gonzalo, del Rio, Joaquin, Lasheras, Berta

“…New 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives were prepared and tested as 5-HT3 receptor antagonists. Some of the new compounds…”
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Thermal decomposition and stability of quinoline compounds using thermogravimetry and differential scanning calorimetry by Lizarraga, Elena, Zabaleta, Camino, Palop, Juan A.

“…Thermal analysis, with DSC and TGA of fusion and decomposition processes of some quinoline compounds were carried out to determine their stability. The…”
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Hypoxia-Selective Agents Derived from 2-Quinoxalinecarbonitrile 1,4-Di-N-oxides. 2 by Monge, Antonio, Martinez-Crespo, Francisco J, Lopez de Cerain, Adela, Palop, Juan A, Narro, Susana, Senador, Virginia, Marin, Ana, Sainz, Yolanda, Gonzalez, Mercedes

“…Hypoxic cells are an important target for antitumor therapy because tumors are typically characterized by such cells. Virtually all tumors which are present as…”
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New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants by MARTINEZ, Javier, PEREZ, Silvia, DEL CASTILLO, Juan-C, LASHERAS, Berta, TORDERA, Rosa, DEL RIO, Joaquin, MONGE, Antonio, OFICIALDEGUI, Ana M, HERAS, Begona, ORUS, Lara, VILLANUEVA, Helena, PALOP, Juan A, ROCA, Joan, MOURELLE, Marisa, BOSCH, Ana

“…A series of new 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives were synthesized in an attempt to find a new class of antidepressant…”
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Synthesis of 3-amino-5H-pyrimido[5,4-b]indol-4-one derivatives by Monge, A., Palop, J. A., Parrado, P., Perez-Ilzarbe, C., Fernández-Alvarez, E.

“…Starting with ethyl 3‐aminoindole‐2‐carboxylate, the synthesis of 3‐amino‐5H‐pyrimido[5,4‐b]indole‐2,4‐dione 5, 3‐amino‐5H‐pyrimido[5,4‐b]indol‐4‐one 10 and…”
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About the synthesis of [1,2]diazepinoindole derivatives from ethyl 2-(1-methylindole)acetate, 2-indole and 3-indoleacetohydrazones by Monge, A., Palop, J. A., Goñí, T., Martínez, A., Fernández-Alvarez, E.

“…The Vilsmeier‐Haack reaction with ethyl 2‐(1‐methylindole)acetate and N,N‐Dimethylamides/phosphorus oxychloride gave (65–85%) of ethyl…”
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New hypoxia-selective cytotoxines derived from quinoxaline 1,4-dioxides by Monge, A., Palop, J. A., González, Mercedes, Martínez-Crespo, F. J., De Ceráin, Adela López, Sáinz, Yolanda, Narro, Susana, Barker, A. J., Hamilton, E.

“…A new series of quinoxaline 1,4‐dioxides, structurally related to the benzotriazine tirapazamine 1 have been prepared starting from 5,6‐dichlorobenzofuroxane…”
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Synthesis of pyridazino[4,5-b]indole derivatives from 2-(3-carboxy-1-methylindole)acetic acid anhydride by Monge, A., Palop, J. A., Goñi, T., Fernández-Alvarez, E.

“…2‐(3‐Carboxy‐1‐methylindole)acetic acid anhydride (1) reacts with aryldiazonium salts to give 85–95% of the corresponding α‐hydrazono anhydrides 2. Treating 2…”
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Synthesis of 3H[1,2]diazepino[5,6-b]indole and 3H[1,2]diazepino[4,5-b]indole derivatives by Monge, A., Palop, J. A., Goñi, T., Martinez, A., Fernández-Alvarez, E.

“…The synthesis of two new derivatives of 3H[1,2]diazepino[5,6‐b]indole, 5 and 11, and one new derivative of 3H[1,2]diazepino[4,5‐b]indole, 16, are described…”
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