Search Results - "Palmiter, Kimberly A"

O' Surgery Case Log Data, Where Art Thou? by Patel, Mayur B., MD, MPH, Guillamondegui, Oscar D., MD, MPH, FACS, Ott, Mickey M., MD, Palmiter, Kimberly A., BS, May, Addison K., MD, FACS

“…Background The American College of Surgeons (ACS) Case Log represents a data system that satisfies the American Board of Surgery (ABS) Maintenance of…”
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Kinetic differences at the single molecule level account for the functional diversity of rabbit cardiac myosin isoforms by Palmiter, Kimberly A., Tyska, Matthew J., Dupuis, Donald E., Alpert, Norman R., Warshaw, David M.

“…Cardiac V3 myosin generates slower actin filament velocities and higher average isometric forces (in an in vitro motility assay) when compared with the V1…”
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Attenuation of length dependence of calcium activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin I by Arteaga, Grace M., Palmiter, Kimberly A., Leiden, Jeffrey M., Solaro, R. John

“…We compared sarcomere length (SL) dependence of the Ca 2+ -force relation of detergent-extracted bundles of fibres dissected from the left ventricle of…”
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Tropomyosin Directly Modulates Actomyosin Mechanical Performance at the Level of a Single Actin Filament by VanBuren, Peter, Palmiter, Kimberly A., Warshaw, David M.

“…Muscle contraction is the result of myosin cross-bridges (XBs) cyclically interacting with the actin-containing thin filament. This interaction is modulated by…”
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The Light Chain Binding Domain of Expressed Smooth Muscle Heavy Meromyosin Acts as a Mechanical Lever by Warshaw, David M., Guilford, William H., Freyzon, Yelena, Krementsova, Elena, Palmiter, Kimberly A., Tyska, Mathew J., Baker, Josh E., Trybus, Kathleen M.

“…Structural data led to the proposal that the molecular motor myosin moves actin by a swinging of the light chain binding domain, or “neck.” To test the…”
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Altered myocardial thin-filament function in the failing Dahl salt-sensitive rat heart: Amelioration by endothelin blockade by NOGUCHI, Teruo, KIHARA, Yasuki, BEGIN, Kelly J, GORGA, Joseph A, PALMITER, Kimberly A, LEWINTER, Martin M, VANBUREN, Peter

“…Dahl salt-sensitive rats fed a high-salt diet develop compensated left ventricular hypertrophy followed by a transition to myocardial failure. We previously…”
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R403Q and L908V mutant beta-cardiac myosin from patients with familial hypertrophic cardiomyopathy exhibit enhanced mechanical performance at the single molecule level by Palmiter, K A, Tyska, M J, Haeberle, J R, Alpert, N R, Fananapazir, L, Warshaw, D M

“…Familial hypertrophic cardiomyopathy (FHC) is a disease of the sarcomere. In the beta-myosin heavy chain gene, which codes for the mechanical enzyme myosin,…”
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Correlation Between Myofilament Response to Ca2+ and Altered Dynamics of Contraction and Relaxation in Transgenic Cardiac Cells That Express beta-Tropomyosin by Wolska, Beata M, Keller, Rebecca S, Evans, Christian C, Palmiter, Kimberly A, Phillips, Ronald M, Muthuchamy, Mariappan, Oehlenschlager, James, Wieczorek, David F, de Tombe, Pieter P, Solaro, R. John

“…We compared the dynamics of the contraction and relaxation of single myocytes isolated from nontransgenic (NTG) mouse hearts and from transgenic (TG-beta-Tm)…”
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Exchange of β- for α-Tropomyosin in Hearts of Transgenic Mice Induces Changes in Thin Filament Response to Ca2+, Strong Cross-bridge Binding, and Protein Phosphorylation (∗) by Palmiter, Kimberly A., Kitada, Yoshimi, Muthuchamy, Mariappan, Wieczorek, David F., Solaro, R. John

“…Despite its potential as a key determinant of the functional state of striated muscle, the impact of tropomyosin (Tm) isoform switching on mammalian…”
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Mutagenesis of cardiac troponin I. Role of the unique NH2-terminal peptide in myofilament activation by XIAODU GUO, WATTANAPERMPOOL, J, PALMITER, K. A, MURPHY, A. M, SOLARO, R. J

“…Phosphorylation of Ser residues in the NH2-terminal extension unique to cardiac troponin I (cTnI) is known to occur through protein kinase A and to alter…”
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Correlation between myofilament response to Ca2+ and altered dynamics of contraction and relaxation in transgenic cardiac cells that express (Beta)-tropomyosin by Wolska, Beata M, Keller, Rebecca S, Evans, Christian C, Palmiter, Kimberly A

“…We compared the dynamics of the contraction and relaxation of single myocytes isolated from nontransgenic (NTG) mouse hearts and from transgenic (TG-beta-Tm)…”
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CGP-48506 increases contractility of ventricular myocytes and myofilaments by effects on actin-myosin reaction by Wolska, B M, Kitada, Y, Palmiter, K A, Westfall, M V, Johnson, M D, Solaro, R J

“…We measured the effects of the benzodiazocine derivative, CGP-48506 (5-methyl-6-phenyl-1,3,5,6-tetrahydro-3,6-methano-1, 5-benzodiazocine-2,4-dione), on…”
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R403Q and L908V mutant [beta]-cardiac myosin from patients with familial hypertrophic cardiomyopathy exhibit enhanced mechanical performance at the single molecule level by Palmiter, Kimberly A, Tyska, Matthew J, Haeberle, Joe R, Alpert, Norman R, Fananapazir, Lameh, Warshaw, David M

“…Familial hypertrophic cardiomyopathy (FHC) is a disease of the sarcomere. In the β-myosin heavy chain gene, which codes for the mechanical enzyme myosin,…”
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Exchange of - for -Tropomyosin in Hearts of Transgenic Mice Induces Changes in Thin Filament Response to Ca, Strong Cross-bridge Binding, and Protein Phosphorylation by Kimberly A. Palmiter, Yoshimi Kitada, Mariappan Muthuchamy, David F. Wieczorek, R. John Solaro

“…Despite its potential as a key determinant of the functional state of striated muscle, the impact of tropomyosin (Tm) isoform switching on mammalian…”
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Correlation Between Myofilament Response to Ca 2+ and Altered Dynamics of Contraction and Relaxation in Transgenic Cardiac Cells That Express β-Tropomyosin by Wolska, Beata M., Keller, Rebecca S., Evans, Christian C., Palmiter, Kimberly A., Phillips, Ronald M., Muthuchamy, Mariappan, Oehlenschlager, James, Wieczorek, David F., de Tombe, Pieter P., Solaro, R. John

“…Abstract —We compared the dynamics of the contraction and relaxation of single myocytes isolated from nontransgenic (NTG) mouse hearts and from transgenic…”
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E-1020, a water soluble imidazopyridine, has direct effects on Ca(2+)-dependent force and ATP hydrolysis of canine and bovine cardiac myofilaments by Powers, F M, Palmiter, K A, Solaro, R J

“…E-1020 is a cardiotonic agent that acts as a cyclic-AMP phosphodiesterase inhibitor but also may have actions which alter myofilament response to Ca2+. To…”
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E-1020, a water soluble imidazopyridine, has direct effects on Ca2+-dependent force and ATP hydrolysis of canine and bovine cardiac myofilaments by Powers, Frances M., Palmiter, Kimberly A., Solaro, R. John

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Slowly exchanging calcium binding sites unique to cardiac/slow muscle troponin C by Pan, B S, Palmiter, K A, Plonczynski, M, Solaro, R J

“…Evidence is presented for the existence of slowly exchanging Ca2(+)-binding sites in troponin C (CTNC) of cardiac and slow twitch skeletal muscles. These sites…”
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