Search Results - "Palmieri, Erika M."

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase by Palmieri, Erika M., Gonzalez-Cotto, Marieli, Baseler, Walter A., Davies, Luke C., Ghesquière, Bart, Maio, Nunziata, Rice, Christopher M., Rouault, Tracey A., Cassel, Teresa, Higashi, Richard M., Lane, Andrew N., Fan, Teresa W.-M., Wink, David A., McVicar, Daniel W.

“…Profound metabolic changes are characteristic of macrophages during classical activation and have been implicated in this phenotype. Here we demonstrate that…”
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Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression by Rice, Christopher M., Davies, Luke C., Subleski, Jeff J., Maio, Nunziata, Gonzalez-Cotto, Marieli, Andrews, Caroline, Patel, Nimit L., Palmieri, Erika M., Weiss, Jonathan M., Lee, Jung-Min, Annunziata, Christina M., Rouault, Tracey A., Durum, Scott K., McVicar, Daniel W.

“…Neutrophils are a vital component of immune protection, yet in cancer they may promote tumour progression, partly by generating reactive oxygen species (ROS)…”
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Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis by Palmieri, Erika M., Menga, Alessio, Martín-Pérez, Rosa, Quinto, Annamaria, Riera-Domingo, Carla, De Tullio, Giacoma, Hooper, Douglas C., Lamers, Wouter H., Ghesquière, Bart, McVicar, Daniel W., Guarini, Attilio, Mazzone, Massimiliano, Castegna, Alessandra

“…Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators,…”
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Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight by Palmieri, Erika M., McGinity, Christopher, Wink, David A., McVicar, Daniel W.

“…Nitric Oxide (NO) is a soluble endogenous gas with various biological functions like signaling, and working as an effector molecule or metabolic regulator. In…”
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Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels by Davies, Luke C., Rice, Christopher M., Palmieri, Erika M., Taylor, Philip R., Kuhns, Douglas B., McVicar, Daniel W.

“…The importance of metabolism in macrophage function has been reported, but the in vivo relevance of the in vitro observations is still unclear. Here we show…”
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Editorial: Understanding how myeloid cell development and function meet tissue distinct metabolic requirements by Palmieri, Erika M, Salmond, Robert J, Menga, Alessio

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Acetylation of human mitochondrial citrate carrier modulates mitochondrial citrate/malate exchange activity to sustain NADPH production during macrophage activation by Palmieri, Erika M., Spera, Iolanda, Menga, Alessio, Infantino, Vittoria, Porcelli, Vito, Iacobazzi, Vito, Pierri, Ciro L., Hooper, Douglas C., Palmieri, Ferdinando, Castegna, Alessandra

“…The mitochondrial citrate–malate exchanger (CIC), a known target of acetylation, is up-regulated in activated immune cells and plays a key role in the…”
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Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming by Palmieri, Erika M., Holewinski, Ronald, McGinity, Christopher L., Pierri, Ciro L., Maio, Nunziata, Weiss, Jonathan M., Tragni, Vincenzo, Miranda, Katrina M., Rouault, Tracey A., Andresson, Thorkell, Wink, David A., McVicar, Daniel W.

“…M1 macrophages enter a glycolytic state when endogenous nitric oxide (NO) reprograms mitochondrial metabolism by limiting aconitase 2 and pyruvate…”
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Glufosinate constrains synchronous and metachronous metastasis by promoting anti‐tumor macrophages by Menga, Alessio, Serra, Marina, Todisco, Simona, Riera‐Domingo, Carla, Ammarah, Ummi, Ehling, Manuel, Palmieri, Erika M, Di Noia, Maria Antonietta, Gissi, Rosanna, Favia, Maria, Pierri, Ciro L, Porporato, Paolo E, Castegna, Alessandra, Mazzone, Massimiliano

“…Glutamine synthetase (GS) generates glutamine from glutamate and controls the release of inflammatory mediators. In macrophages, GS activity, driven by IL10,…”
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Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses by Walls, Jessica F, Subleski, Jeff J, Palmieri, Erika M, Gonzalez-Cotto, Marieli, Gardiner, Clair M, McVicar, Daniel W, Finlay, David K

“…Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating changes in signal transduction pathways and cellular…”
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Itaconic acid underpins hepatocyte lipid metabolism in non-alcoholic fatty liver disease in male mice by Weiss, Jonathan M., Palmieri, Erika M., Gonzalez-Cotto, Marieli, Bettencourt, Ian A., Megill, Emily L., Snyder, Nathaniel W., McVicar, Daniel W.

“…Itaconate, the product of the decarboxylation of cis -aconitate, regulates numerous biological processes. We and others have revealed itaconate as a regulator…”
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Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment by McGinity, Christopher L, Palmieri, Erika M, Somasundaram, Veena, Bhattacharyya, Dibyangana D, Ridnour, Lisa A, Cheng, Robert Y S, Ryan, Aideen E, Glynn, Sharon A, Thomas, Douglas D, Miranda, Katrina M, Anderson, Stephen K, Lockett, Stephen J, McVicar, Daniel W, Wink, David A

“…The metabolic requirements and functions of cancer and normal tissues are vastly different. Due to the rapid growth of cancer cells in the tumor…”
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TREML4 Promotes Inflammatory Programs in Human and Murine Macrophages and Alters Atherosclerosis Lesion Composition in the Apolipoprotein E Deficient Mouse by Gonzalez-Cotto, Marieli, Guo, Liang, Karwan, Megan, Sen, Shurjo K, Barb, Jennifer, Collado, Carlos J, Elloumi, Fathi, Palmieri, Erika M, Boelte, Kimberly, Kolodgie, Frank D, Finn, Aloke V, Biesecker, Leslie G, McVicar, Daniel W

“…The Triggering Receptor Expressed on Myeloid cells-like 4 (TREML4) is a member of the TREM receptor family, known modulators of inflammatory responses. We have…”
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Editorial: Metabolism Meets Function: Untangling the Cross-Talk Between Signaling and Metabolism by Castegna, Alessandra, McVicar, Daniel W., Campanella, Annalisa, Palmieri, Erika M., Menga, Alessio, Porporato, Paolo E.

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TLR-activated repression of Fe-S cluster biogenesis drives a metabolic shift and alters histone and tubulin acetylation by Tong, Wing-Hang, Maio, Nunziata, Zhang, De-Liang, Palmieri, Erika M., Ollivierre, Hayden, Ghosh, Manik C., McVicar, Daniel W., Rouault, Tracey A.

“…Given the essential roles of iron-sulfur (Fe-S) cofactors in mediating electron transfer in the mitochondrial respiratory chain and supporting heme…”
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Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells by Palmieri, Erika M, Menga, Alessio, Lebrun, Aurore, Hooper, Douglas C, Butterfield, D Allan, Mazzone, Massimiliano, Castegna, Alessandra

“…Microglial cells are brain-resident macrophages engaged in surveillance and maintained in a constant state of relative inactivity. However, their involvement…”
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SLC25A26 overexpression impairs cell function via mtDNA hypermethylation and rewiring of methyl metabolism by Menga, Alessio, Palmieri, Erika M., Cianciulli, Antonia, Infantino, Vittoria, Mazzone, Massimiliano, Scilimati, Antonio, Palmieri, Ferdinando, Castegna, Alessandra, Iacobazzi, Vito

“…Cancer cells down‐regulate different genes to give them a selective advantage in invasiveness and/or metastasis. The SLC25A26 gene encodes the mitochondrial…”
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Monoamine oxidase-dependent histamine catabolism accounts for post-ischemic cardiac redox imbalance and injury by Costiniti, Veronica, Spera, Iolanda, Menabò, Roberta, Palmieri, Erika M., Menga, Alessio, Scarcia, Pasquale, Porcelli, Vito, Gissi, Rosanna, Castegna, Alessandra, Canton, Marcella

“…Monoamine oxidase (MAO), a mitochondrial enzyme that oxidizes biogenic amines generating hydrogen peroxide, is a major source of oxidative stress in cardiac…”
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Clinical implications from proteomic studies in neurodegenerative diseases: lessons from mitochondrial proteins by Butterfield, D Allan, Palmieri, Erika M, Castegna, Alessandra

“…Mitochondria play a key role in eukaryotic cells, being mediators of energy, biosynthetic and regulatory requirements of these cells. Emerging proteomics…”
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Pyruvate Dehydrogenase Operates as an Intramolecular Nitroxyl Generator During Macrophage Metabolic Reprogramming by Palmieri, Erika M, Holewinski, Ronald, McGinity, Christopher, Pierri, Ciro, Maio, Nunziata, Wink, David, McVicar, Daniel W

“…Abstract M1 macrophages “commit” to a glycolytic state when endogenous nitric oxide (NO) reprograms mitochondrial metabolism by limiting aconitase (Aco)-2 and…”
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