Search Results - "Palmer, Stephen S."

c-Jun NH2 -terminal kinase inhibitor bentamapimod reduces induced endometriosis in baboons: an assessor-blind placebo-controlled randomized study by Hussein, Mostafa, M.D, Chai, Daniel C., D.V.M, Kyama, Cleophas M., Ph.D, Mwenda, Jason M., Ph.D, Palmer, Stephen S., Ph.D, Gotteland, Jean-Pierre, Ph.D, D'Hooghe, Thomas M., M.D

“…Objective To test the hypothesis that the c-Jun NH2 -terminal kinase (JNK) inhibitor (JNKI) bentamapimod (AS602801/PGL5001) can reduce induced endometriosis in…”
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Discovery and Development of Small Molecule Allosteric Modulators of Glycoprotein Hormone Receptors by Nataraja, Selvaraj G, Yu, Henry N, Palmer, Stephen S

“…Glycoprotein hormones, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyroid-stimulating hormone (TSH) are heterodimeric proteins with a…”
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Biomarkers in reproductive medicine: the promise, and can it be fulfilled? by Palmer, Stephen S., Ph.D, Barnhart, Kurt T., M.D., M.S.C.E

“…A biomarker can be used for early diagnosis of a disease, identification of individuals for disease prevention, as a potential drug target, or as a potential…”
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Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor by De Pascali, Francesco, Ayoub, Mohammed Akli, Benevelli, Riccardo, Sposini, Silvia, Lehoux, Jordan, Gallay, Nathalie, Raynaud, Pauline, Landomiel, Flavie, Jean-Alphonse, Frédéric, Gauthier, Christophe, Pellissier, Lucie P., Crépieux, Pascale, Poupon, Anne, Inoue, Asuka, Joubert, Nicolas, Viaud-Massuard, Marie-Claude, Casarini, Livio, Simoni, Manuela, Hanyaloglu, Aylin C., Nataraja, Selva G., Yu, Henry N., Palmer, Stephen S., Yvinec, Romain, Reiter, Eric

“…Follicle-stimulating hormone receptor (FSHR) plays a key role in reproduction through the activation of multiple signaling pathways. Low molecular weight (LMW)…”
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Follicle-Stimulating Hormone Induces Lipid Droplets via Gαi/o and β-Arrestin in an Endometrial Cancer Cell Line by Sayers, Niamh S, Anujan, Priyanka, Yu, Henry N, Palmer, Stephen S, Nautiyal, Jaya, Franks, Stephen, Hanyaloglu, Aylin C

“…Follicle-stimulating hormone (FSH) and its G protein-coupled receptor, FSHR, represents a paradigm for receptor signaling systems that activate multiple and…”
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Follicle-stimulating Hormone Activates Extracellular Signal-regulated Kinase but Not Extracellular Signal-regulated Kinase Kinase through a 100-kDa Phosphotyrosine Phosphatase by Cottom, Joshua, Salvador, Lisa M, Maizels, Evelyn T, Reierstad, Scott, Park, Youngkyu, Carr, Daniel W, Davare, Monika A, Hell, Johannes W, Palmer, Stephen S, Dent, Paul, Kawakatsu, Hisaaki, Ogata, Masato, Hunzicker-Dunn, Mary

“…In this report we sought to elucidate the mechanism by which the follicle-stimulating hormone (FSH) receptor signals to promote activation of the p42/p44…”
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Discovery and characterization of bromodomain 2–specific inhibitors of BRDT by Yu, Zhifeng, Ku, Angela F., Anglin, Justin L., Sharma, Rajesh, Ucisik, Melek Nihan, Faver, John C., Li, Feng, Nyshadham, Pranavanand, Simmons, Nicholas, Sharma, Kiran L., Nagarajan, Sureshbabu, Riehle, Kevin, Kaur, Gundeep, Sankaran, Banumathi, Storl-Desmond, Marta, Palmer, Stephen S., Young, Damian W., Kim, Choel, Matzuk, Martin M.

“…Bromodomain testis (BRDT), a member of the bromodomain and extraterminal (BET) subfamily that includes the cancer targets BRD2, BRD3, and BRD4, is a validated…”
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Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening by Modukuri, Ram K., Monsivais, Diana, Li, Feng, Palaniappan, Murugesan, Bohren, Kurt M., Tan, Zhi, Ku, Angela F., Wang, Yong, Madasu, Chandrashekhar, Li, Jian-Yuan, Tang, Suni, Miklossy, Gabriella, Palmer, Stephen S., Young, Damian W., Matzuk, Martin M.

“…The discovery of monokinase-selective inhibitors for patients is challenging because the 500+ kinases encoded by the human genome share highly conserved…”
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DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors by Chamakuri, Srinivas, Lu, Shuo, Ucisik, Melek Nihan, Bohren, Kurt M., Chen, Ying-Chu, Du, Huang-Chi, Faver, John C., Jimmidi, Ravikumar, Li, Feng, Li, Jian-Yuan, Nyshadham, Pranavanand, Palmer, Stephen S., Pollet, Jeroen, Qin, Xuan, Ronca, Shannon E., Sankaran, Banumathi, Sharma, Kiran L., Tan, Zhi, Versteeg, Leroy, Yu, Zhifeng, Matzuk, Martin M., Palzkill, Timothy, Young, Damian W.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 4 million humans globally, but there is no bona fide Food and Drug…”
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Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections by Modukuri, Ram K, Yu, Zhifeng, Tan, Zhi, Ta, Hai Minh, Ucisik, Melek Nihan, Jin, Zhuang, Anglin, Justin L, Sharma, Kiran L, Nyshadham, Pranavanand, Li, Feng, Riehle, Kevin, Faver, John C, Duong, Kevin, Nagarajan, Sureshbabu, Simmons, Nicholas, Palmer, Stephen S, Teng, Mingxing, Young, Damian W, Yi, Joanna S, Kim, Choel, Matzuk, Martin M

“…SignificanceBET bromodomain inhibition is therapeutic in multiple diseases; however, pan-BET inhibitors have induced significant myelosuppression and…”
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Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology by Jimmidi, Ravikumar, Monsivais, Diana, Ta, Hai Minh, Sharma, Kiran L., Bohren, Kurt M., Chamakuri, Srinivas, Liao, Zian, Li, Feng, Hakenjos, John M., Li, Jian-Yuan, Mishina, Yuji, Pan, Haichun, Qin, Xuan, Robers, Matthew B., Sankaran, Banumathi, Tan, Zhi, Tang, Suni, Vasquez, Yasmin M., Wilkinson, Jennifer, Young, Damian W., Palmer, Stephen S., MacKenzie, Kevin R., Kim, Choel, Matzuk, Martin M.

“…Activin receptor type 1 (ACVR1; ALK2) and activin receptor like type 1 (ACVRL1; ALK1) are transforming growth factor beta family receptors that integrate…”
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Reversible male contraception by targeted inhibition of serine/threonine kinase 33 by Ku, Angela F, Sharma, Kiran L, Ta, Hai Minh, Sutton, Courtney M, Bohren, Kurt M, Wang, Yong, Chamakuri, Srinivas, Chen, Ruihong, Hakenjos, John M, Jimmidi, Ravikumar, Kent, Katarzyna, Li, Feng, Li, Jian-Yuan, Ma, Lang, Madasu, Chandrashekhar, Palaniappan, Murugesan, Palmer, Stephen S, Qin, Xuan, Robers, Matthew B, Sankaran, Banumathi, Tan, Zhi, Vasquez, Yasmin M, Wang, Jian, Wilkinson, Jennifer, Yu, Zhifeng, Ye, Qiuji, Young, Damian W, Teng, Mingxing, Kim, Choel, Matzuk, Martin M

“…Men or mice with homozygous serine/threonine kinase 33 ( ) mutations are sterile owing to defective sperm morphology and motility. To chemically evaluate STK33…”
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Pharmacological and Functional Characterization of Novel EP and DP Receptor Agonists: DP1 Receptor Mediates Penile Erection in Multiple Species by Brugger, Nadia, Kim, Noel N., Araldi, Gian Luca, Traish, Abdulmaged M., Palmer, Stephen S.

“…Despite the widespread use of prostaglandin E1 as an efficacious treatment for male erectile dysfunction for more than two decades, research on prostanoid…”
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Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models by Palmer, Stephen S, Altan, Melis, Denis, Deborah, Tos, Enrico Gillio, Gotteland, Jean-Pierre, Osteen, Kevin G, Bruner-Tran, Kaylon L, Nataraja, Selvaraj G

“…Endometriosis is an estrogen (ER)-dependent gynecological disease caused by the growth of endometrial tissue at extrauterine sites. Current endocrine therapies…”
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A long-acting tumor necrosis factor alpha-binding protein demonstrates activity in both in vitro and in vivo models of endometriosis by Altan, Z Melis, Denis, Deborah, Kagan, David, Grund, Eric M, Palmer, Stephen S, Nataraja, Selvaraj G

“…Endometriosis is characterized by the presence of elevated proinflammatory cytokines such as tumor necrosis factor (TNF) alpha in the peritoneal cavity…”
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Relaxin Increases Secretion of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 during Uterine and Cervical Growth and Remodeling in the Pig by Lenhart, Judy A, Ryan, Peter L, Ohleth, Kathleen M, Palmer, Stephen S, Bagnell, Carol A

“…Matrix metalloproteinases are proteolytic enzymes that degrade the extracellular matrix and are essential for tissue remodeling. Uterine and cervical growth…”
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Discovery of new molecules for future treatment of infertility by Palmer, Stephen S, McKenna, Sean, Arkinstall, Steve

“…The introduction of recombinant gonadotrophins for the treatment of infertility has been an important advance in improving the quality and consistency of…”
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Relaxin Increases Secretion of Tissue Inhibitor of Matrix Metalloproteinase-1 and -2 during Uterine and Cervical Growth and Remodeling in the Pig by Lenhart, Judy A, Ryan, Peter L, Ohleth, Kathleen M, Palmer, Stephen S, Bagnell, Carol A

“…Remodeling of reproductive organs during pregnancy requires degradation and resynthesis of structural barriers to cell invasion. Matrix metalloproteinases…”
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DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M pro inhibitors by Chamakuri, Srinivas, Lu, Shuo, Ucisik, Melek Nihan, Bohren, Kurt M., Chen, Ying-Chu, Du, Huang-Chi, Faver, John C., Jimmidi, Ravikumar, Li, Feng, Li, Jian-Yuan, Nyshadham, Pranavanand, Palmer, Stephen S., Pollet, Jeroen, Qin, Xuan, Ronca, Shannon E., Sankaran, Banumathi, Sharma, Kiran L., Tan, Zhi, Versteeg, Leroy, Yu, Zhifeng, Matzuk, Martin M., Palzkill, Timothy, Young, Damian W.

“…Significance SARS-CoV-2 has had a crippling impact on human life globally. Vaccine development has been used as a first-line strategy for COVID-19 prevention…”
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Fluorescence polarization assay and SDS-PAGE confirms matrilysin degrades fibronectin and collagen IV whereas gelatinase A degrades collagen IV but not fibronectin by Kraft, P J, Haynes-Johnson, D E, Patel, L, Lenhart, J A, Zivin, R A, Palmer, S S

“…Matrilysin and gelatinase A are hypothesized to have significant roles in uterine and ovarian function. However, proteolytic activity assays for these enzymes…”
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