Search Results - "Palmer, James A"

The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study by Schmidt, Mark E, Liebowitz, Michael R, Stein, Murray B, Grunfeld, Jennifer, Van Hove, Ilse, Simmons, W Kyle, Van Der Ark, Peter, Palmer, James A, Saad, Ziad S, Pemberton, Darrel J, Van Nueten, Luc, Drevets, Wayne C

“…JNJ-42165279 is a selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for the degradation of fatty acid amides (FAA) including…”
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Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice by Mamad, Omar, Heiland, Mona, Lindner, Andreas U, Hill, Thomas D M, Ronroy, Ronan M, Rentrup, Kilian, Sanz-Rodriguez, Amaya, Langa, Elena, Heller, Janosch P, Moreno, Oscar, Llop, Jordi, Bhattacharya, Anindya, Palmer, James A, Ceusters, Marc, Engel, Tobias, Henshall, David C

“…There remains a need for new drug targets for treatment-resistant temporal lobe epilepsy. The ATP-gated P2X7 receptor coordinates neuroinflammatory responses…”
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Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase by Karbarz, Mark J., Luo, Lin, Chang, Leon, Tham, Chui-Se, Palmer, James A., Wilson, Sandy J., Wennerholm, Michelle L., Brown, Sean M., Scott, Brian P., Apodaca, Richard L., Keith, John M., Wu, Jiejun, Breitenbucher, James Guy, Chaplan, Sandra R., Webb, Michael

“…Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme within the amidase-signature family. It catalyzes the hydrolysis of several endogenous…”
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Altered nociception, analgesia and aggression in mice lacking the receptor for substance P by Hunt, Stephen P, Felipe, Carmen De, Herrero, Juan F, O'Brien, John A, Palmer, James A, Doyle, Christopher A, Smith, Andrew J. H, Laird, Jennifer M. A, Belmonte, Carlos, Cervero, Fernando

“…The peptide neurotransmitter substance P modulates sensitivity to pain by activating the neurokinin-1 (NK-1) receptor, which is expressed by discrete…”
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Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase by Keith, John M., Jones, William, Pierce, Joan M., Seierstad, Mark, Palmer, James A., Webb, Michael, Karbarz, Mark, Scott, Brian P., Wilson, Sandy J., Luo, Lin, Wennerholm, Michelle, Chang, Leon, Rizzolio, Michele, Rynberg, Raymond, Chaplan, Sandra, Guy Breitenbucher, J.

“…[Display omitted] A series of mechanism-based heteroaryl urea fatty acid amide hydrolase (FAAH) inhibitors with fused bicyclic diamine cores is described. In…”
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Medieval and Renaissance Rome: Mending the divide by Palmer, James A.

“…Historians of late medieval and renaissance Italy have long seen the fourteenth century as a dramatic period of upheaval and transformation. Yet despite the…”
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Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms by Chang, Leon, Luo, Lin, Palmer, James A, Sutton, Steven, Wilson, Sandy J, Barbier, Ann J, Breitenbucher, James Guy, Chaplan, Sandra R, Webb, Michael

“…1 The reversible fatty acid amide hydrolase (FAAH) inhibitor OL135 reverses mechanical allodynia in the spinal nerve ligation (SNL) and mild thermal injury…”
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Fatty Acid Amide Hydrolase Inhibition by JNJ‐42165279: A Multiple‐Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers by Postnov, Andrey, Schmidt, Mark E., Pemberton, Darrel J., Hoon, Jan, Hecken, Anne, den Boer, Maarten, Zannikos, Peter, der Ark, Peter, Palmer, James A., Rassnick, Stef, Celen, Sofie, Bormans, Guy, Laere, Koen

“…Inhibition of fatty acid amide hydrolase (FAAH) potentiates endocannabinoid activity and is hypothesized to have therapeutic potential for mood and anxiety…”
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Piety and Social Distinction in Late Medieval Roman Peacemaking by Palmer, James A.

“…On a hot August day in the summer of 1364, a Roman grocer named Nucio stood idly in a piazza in the contrada known as Ponte di Santa Maria, near the ancient…”
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Preclinical Characterization of the FAAH Inhibitor JNJ-42165279 by Keith, John M, Jones, William M, Tichenor, Mark, Liu, Jing, Seierstad, Mark, Palmer, James A, Webb, Michael, Karbarz, Mark, Scott, Brian P, Wilson, Sandy J, Luo, Lin, Wennerholm, Michelle L, Chang, Leon, Rizzolio, Michele, Rynberg, Raymond, Chaplan, Sandra R, Breitenbucher, J. Guy

“…The pre-clinical characterization of the aryl piperazinyl urea inhibitor of fatty acid amide hydrolase (FAAH) JNJ-42165279 is described. JNJ-42165279…”
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A Phase 1 First‐in‐Human Pharmacokinetic and Pharmacodynamic Study of JNJ‐64264681, a Covalent Inhibitor of Bruton's Tyrosine Kinase by Leu, Jocelyn H., Miao, Xin, Shalayda, Kevin, Coe, Kevin J., Kahnt, Ariane, Wu, Bonnie, Schnarr, Megan, Franks, Carol, Devlin, James, Yang, Tong‐Yuan, Palmer, James A., Zhang, Mai, Zhou, Honghui, Van Damme, Wim, Smets, Sophie, Aguilar, Zuleima, Chaplan, Sandra R.

“…JNJ‐64264681 is an irreversible covalent inhibitor of Bruton's tyrosine kinase. This phase 1, first‐in‐human, 2‐part (single‐ascending dose [SAD];…”
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The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors by Keith, John M., Tichenor, Mark S., Apodaca, Richard L., Xiao, Wei, Jones, William M., Seierstad, Mark, Pierce, Joan M., Palmer, James A., Webb, Michael, Karbarz, Mark J., Scott, Brian P., Wilson, Sandy J., Wennerholm, Michelle L., Rizzolio, Michele, Rynberg, Raymond, Chaplan, Sandra R., Breitenbucher, J. Guy

“…The SAR of brain penetration for a series of heteroaryl piperazinyl- and piperadinyl-urea fatty acid amide hydrolase (FAAH) inhibitors is described…”
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Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase by Keith, John M., Jones, William M., Pierce, Joan M., Seierstad, Mark, Palmer, James A., Webb, Michael, Karbarz, Mark J., Scott, Brian P., Wilson, Sandy J., Luo, Lin, Wennerholm, Michelle L., Chang, Leon, Brown, Sean M., Rizzolio, Michele, Rynberg, Raymond, Chaplan, Sandra R., Breitenbucher, J. Guy

“…A series of diamino spirocyclic aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting…”
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Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites by Tichenor, Mark S., Keith, John M., Jones, William M., Pierce, Joan M., Merit, Jeff, Hawryluk, Natalie, Seierstad, Mark, Palmer, James A., Webb, Michael, Karbarz, Mark J., Wilson, Sandy J., Wennerholm, Michelle L., Woestenborghs, Filip, Beerens, Dominiek, Luo, Lin, Brown, Sean M., Boeck, Marlies De, Chaplan, Sandra R., Breitenbucher, J. Guy

“…The structure–activity relationships for a series of heteroaryl urea inhibitors of fatty acid amide hydrolase (FAAH) are described. Members of this class of…”
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1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase by Keith, John M, Hawryluk, Natalie, Apodaca, Richard L, Chambers, Allison, Pierce, Joan M, Seierstad, Mark, Palmer, James A, Webb, Michael, Karbarz, Mark J, Scott, Brian P, Wilson, Sandy J, Luo, Lin, Wennerholm, Michelle L, Chang, Leon, Rizzolio, Michele, Chaplan, Sandra R, Breitenbucher, J Guy

“…A series of 1-aryl-2-(((6-aryl)pyrimidin-4-yl)amino)ethanols have been found to be competitive inhibitors of fatty acid amide hydrolase (FAAH). One member of…”
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Multiple Immediate-Early Gene-Deficient Herpes Simplex Virus Vectors Allowing Efficient Gene Delivery to Neurons in Culture and Widespread Gene Delivery to the Central Nervous System In Vivo by Lilley, C E, Groutsi, F, Han, Z, Palmer, J A, Anderson, P N, Latchman, D S, Coffin, R S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Effect of Wire Diameter and Addition of an Axial Magnetic Field on the Dynamics of Radial Wire Array Z-Pinches by Suzuki-Vidal, Francisco, Lebedev, Sergey V, Bland, Simon N, Hall, Gareth N, Harvey-Thompson, Adam J, Chittenden, Jeremy P, Marocchino, Alberto, Bott, Simon C, Palmer, James, Ciardi, Andrea

“…The operation of radial wire array Z -pinches driven by a 1-MA 250-ns current pulse was studied. Variation in the cathode diameter and wire diameter does not…”
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Disruption of the substance P receptor (neurokinin-1) gene does not prevent upregulation of preprotachykinin-A mRNA in the spinal cord of mice following peripheral inflammation by Palmer, James A., De Felipe, Carmen, O'Brien, John A., Hunt, Stephen P.

“…The neuropeptide substance P is thought to play an important role in nociception, although the function of the peptide remains controversial. Following…”
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Ai margini dei giganti: La vita intellettuale dei Romani nel Trecento (1305–1367 ca.). Dario Internullo. Italia comunale e signorile 10. Rome: Viella, 2016. 532 pp. + 8 b/w pls. €49 by Palmer, James A.

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Modifying Wire-Array Z-Pinch Ablation Structure and Implosion Dynamics Using Coiled Wires by Hall, G.N., Bland, S.N., Lebedev, S.V., Chittenden, J.P., Palmer, J., Suzuki-Vidal, F.A., Harvey-Thompson, A.J., Swadling, G.F., Niasse, N., Bott, S.C.

“…Coiled arrays, which are cylindrical arrays in which each wire is formed into a helix, suppress the modulation of ablation at the fundamental wavelength…”
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