Search Results - "Palmer, James T."

A Novel, Orally Bioavailable, Small-Molecule Inhibitor of PCSK9 With Significant Cholesterol-Lowering Properties In Vivo by Suchowerska, Alexandra K., Stokman, Geurt, Palmer, James T., Coghlan, Phillip A., Pieterman, Elsbet J., Keijzer, Nanda, Lambert, Gilles, Chemello, Kevin, Jaafar, Ali K., Parmar, Jasneet, Yan, Liping, Tong, Yingtao, Mu, Lin, Princen, Hans M.G., Bonnar, James, Evison, Benny J.

“…Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibits the clearance of low-density lipoprotein (LDL) cholesterol (LDL-C) from plasma by directly…”
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Discovery of Selective Irreversible Inhibitors for Bruton's Tyrosine Kinase by Pan, Zhengying, Scheerens, Heleen, Li, Shyr-Jiann, Schultz, Brian E., Sprengeler, Paul A., Burrill, L. Chuck, Mendonca, Rohan V., Sweeney, Michael D., Scott, Keana C. K., Grothaus, Paul G., Jeffery, Douglas A., Spoerke, Jill M., Honigberg, Lee A., Young, Peter R., Dalrymple, Stacie A., Palmer, James T.

“…A series of highly selective irreversible inhibitors for Bruton's tyrosine kinase (Btk) was developed using a structural bioinformatics approach. Their…”
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A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove by Evison, Benny J., Palmer, James T., Lambert, Gilles, Treutlein, Herbert, Zeng, Jun, Nativel, Brice, Chemello, Kévin, Zhu, Qing, Wang, Jie, Teng, Yanfen, Tang, Wei, Xu, Yanfeng, Rathi, Anuj Kumar, Kumar, Sanjay, Suchowerska, Alexandra K., Parmar, Jasneet, Dixon, Ian, Kelly, Graham E., Bonnar, James

“…[Display omitted] Proprotein convertase (PC) subtilisin kexin type 9 (PCSK9) inhibits the clearance of low density lipoprotein (LDL) cholesterol from plasma by…”
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The making of a world historical moment: The Battle of Tours (732/3) in the nineteenth century by Palmer, James T.

“…The Battle of Tours (or Poitiers) in 732/3 is frequently cited as a turning point in world history, when the advance of Muslim Arabs was decisively halted by…”
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The Crystal Structure of Human Cathepsin F and Its Implications for the Development of Novel Immunomodulators by Somoza, John R., Palmer, James T., Ho, Joseph D.

“…Cathepsin F is a lysosomal cysteine protease of the papain family, and likely plays a regulatory role in processing the invariant chain that is associated with…”
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The Global Eminent Life: Sixth-Century Collected Biographies from Gregory of Tours to Huijiao of Jiaxiang Temple by Palmer, James T.

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Sweet chestnut rutstroemias (Sclerotiniaceae) on an acorn and oak cupules, and Sclerotinia gregoriana n.sp. on deer-grass (Investigations into the Sclerotiniaceae - II) by James T. Palmer

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Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors by Axford, Lorraine C., Agarwal, Piyush K., Anderson, Kelly H., Andrau, Laura N., Atherall, John, Barker, Stephanie, Bennett, James M., Blair, Michael, Collins, Ian, Czaplewski, Lloyd G., Davies, David T., Gannon, Carlie T., Kumar, Dushyant, Lancett, Paul, Logan, Alastair, Lunniss, Christopher J., Mitchell, Dale R., Offermann, Daniel A., Palmer, James T., Palmer, Nicholas, Pitt, Gary R.W., Pommier, Stéphanie, Price, Daniel, Narasinga Rao, B., Saxena, Rashmi, Shukla, Tarun, Singh, Amit K., Singh, Mahipal, Srivastava, Anil, Steele, Christopher, Stokes, Neil R., Thomaides-Brears, Helena B., Tyndall, Edward M., Watson, David, Haydon, David J.

“…The discovery and optimisation of a new class of benzothiazole small molecules that inhibit bacterial DNA gyrase and topoisomerase IV are described…”
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Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors by Palmer, James T., Axford, Lorraine C., Barker, Stephanie, Bennett, James M., Blair, Michael, Collins, Ian, Davies, David T., Ford, Leigh, Gannon, Carlie T., Lancett, Paul, Logan, Alastair, Lunniss, Christopher J., Morton, Craig J., Offermann, Daniel A., Pitt, Gary R.W., Rao, B. Narasinga, Singh, Amit K., Shukla, Tarun, Srivastava, Anil, Stokes, Neil R., Thomaides-Brears, Helena B., Yadav, Anju, Haydon, David J.

“…A series of dual-targeting, alcohol-containing benzothiazoles has been identified with superior antibacterial activity and drug-like properties. Early lead…”
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Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs) by Burns, Christopher J., Bourke, David G., Andrau, Laura, Bu, Xianyong, Charman, Susan A., Donohue, Andrew C., Fantino, Emmanuelle, Farrugia, Michelle, Feutrill, John T., Joffe, Max, Kling, Marcel R., Kurek, Margarita, Nero, Tracy L., Nguyen, Thao, Palmer, James T., Phillips, Ian, Shackleford, David M., Sikanyika, Harrison, Styles, Michelle, Su, Stephen, Treutlein, Herbert, Zeng, Jun, Wilks, Andrew F.

“…Details of SAR studies leading to CYT387, a potent and selective dual JAK1 and JAK2 inhibitor, are reported. A series of phenylaminopyrimidines has been…”
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Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K by Black, W. Cameron, Bayly, Christopher I., Davis, Dana E., Desmarais, Sylvie, Falgueyret, Jean-Pierre, Léger, Serge, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Palmer, James T., Percival, M. David, Robichaud, Joël, Tsou, Nancy, Zamboni, Robert

“…Replacing an amide bond with a trifluoroethylamine leads to potent and selective inhibitors of cathepsin K. The CF 3 group provides a non-basic amine that…”
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Optimization of Subsite Binding to the β5 Subunit of the Human 20S Proteasome Using Vinyl Sulfones and 2-Keto-1,3,4-oxadiazoles:  Syntheses and Cellular Properties of Potent, Selective Proteasome Inhibitors by Rydzewski, Robert M, Burrill, Leland, Mendonca, Rohan, Palmer, James T, Rice, Mark, Tahilramani, Ram, Bass, Kathryn E, Leung, Ling, Gjerstad, Erik, Janc, James W, Pan, Lin

“…Beginning with the peptide sequence Cbz-Ile-Glu(OtBu)-Ala-Leu found in PSI (3), a series of vinyl sulfones (VS) were synthesized for evaluation as inhibitors…”
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Keto-1,3,4-oxadiazoles as cathepsin K inhibitors by Palmer, James T., Hirschbein, Bernard L., Cheung, Harry, McCarter, John, Janc, James W., Yu, Z. Walter, Wesolowski, Gregg

“…We have prepared a series of cathepsin K inhibitors bearing the keto-1,3,4-oxadiazole warhead capable of forming a hemithioketal complex with the target…”
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Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors by Palmer, James T, Rasnick, David, Klaus, Jeffrey L, Bromme, Dieter

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A Novel Class of Nonpeptidic Biaryl Inhibitors of Human Cathepsin K by Robichaud, Joël, Oballa, Renata, Prasit, Peppi, Falgueyret, Jean-Pierre, Percival, M. David, Wesolowski, Gregg, Rodan, Sevgi B, Kimmel, Donald, Johnson, Colena, Bryant, Cliff, Venkatraman, Shankar, Setti, Eduardo, Mendonca, Rohan, Palmer, James T

“…A novel series of nonpeptidic biaryl compounds was identified as potent and reversible inhibitors of cathepsin K. The P2−P3 amide bond of a known amino…”
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Evidence for a Protective Role of Metallothionein-1 in Focal Cerebral Ischemia by Menno van Lookeren Campagne, Thibodeaux, Harold, van Bruggen, Nick, Cairns, Belinda, Gerlal, Robert, Palmer, James T., Williams, Simon P., Lowe, David G.

“…Metallothioneins (MTs) are a family of metal binding proteins that have been proposed to participate in a cellular defense against zinc toxicity and free…”
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VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain by van Bruggen, Nicholas, Thibodeaux, Harold, Palmer, James T., Lee, Wyne P., Fu, Ling, Cairns, Belinda, Tumas, Daniel, Gerlai, Robert, Williams, Simon-Peter, Campagne, Menno van Lookeren, Ferrara, Napoleone

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The Christian Economy in the Early Medieval West: Towards a Temple Society. By Ian N.Wood. Binghamton, NY: Punctum Books. 2022. ISBN 978 1 68571 027 9 (ePDF). Open Access by Palmer, James T.

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Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K by Setti, Eduardo L., Venkatraman, Shankar, Palmer, James T., Xie, Xiaoming, Cheung, Harry, Yu, Walter, Wesolowski, Gregg, Robichaud, Joel

“…A novel series of potent and selective inhibitors of cysteine protease cathepsin K is described. The synthesis and biological profile of a novel series of…”
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β-Substituted Cyclohexanecarboxamide:  A Nonpeptidic Framework for the Design of Potent Inhibitors of Cathepsin K by Crane, Sheldon N, Black, W. Cameron, Palmer, James T, Davis, Dana E, Setti, Eduardo, Robichaud, Joel, Paquet, Julie, Oballa, Renata M, Bayly, Christopher I, McKay, Daniel J, Somoza, John R, Chauret, Natalie, Seto, Carmai, Scheigetz, John, Wesolowski, Greg, Massé, Frederic, Desmarais, Sylvie, Ouellet, Marc

“…A new series of nonpeptidic cathepsin K inhibitors that are based on a β-substituted cyclohexanecarboxamide motif has been developed. Lead optimization yielded…”
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