Search Results - "Palmer, Héctor G."

Interrogating open issues in cancer precision medicine with patient-derived xenografts by Byrne, Annette T., Alférez, Denis G., Amant, Frédéric, Annibali, Daniela, Arribas, Joaquín, Biankin, Andrew V., Bruna, Alejandra, Budinská, Eva, Caldas, Carlos, Chang, David K., Clarke, Robert B., Clevers, Hans, Coukos, George, Dangles-Marie, Virginie, Eckhardt, S. Gail, Gonzalez-Suarez, Eva, Hermans, Els, Hidalgo, Manuel, Jarzabek, Monika A., de Jong, Steven, Jonkers, Jos, Kemper, Kristel, Lanfrancone, Luisa, Mælandsmo, Gunhild Mari, Marangoni, Elisabetta, Marine, Jean-Christophe, Medico, Enzo, Norum, Jens Henrik, Palmer, Héctor G., Peeper, Daniel S., Pelicci, Pier Giuseppe, Piris-Gimenez, Alejandro, Roman-Roman, Sergio, Rueda, Oscar M., Seoane, Joan, Serra, Violeta, Soucek, Laura, Vanhecke, Dominique, Villanueva, Alberto, Vinolo, Emilie, Bertotti, Andrea, Trusolino, Livio

“…This Opinion article discusses progress and challenges in using patient-derived xenograft (PDX) models in cancer precision medicine. It is primarily…”
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A Personalized Preclinical Model to Evaluate the Metastatic Potential of Patient-Derived Colon Cancer Initiating Cells by PUIG, Isabel, CHICOTE, Irene, MENDIZABAL, Leire, MORENO, Debora, CHARCO, Ramón, ESPIN, Eloy, PRAT, Aleix, ELEZ, Maria Elena, ARGILES, Guillem, VIVANCOS, Ana, TABERNERO, Josep, ROJAS, Santiago, TENBAUM, Stephan P, PALMER, Hector G, ARQUES, Oriol, HERANCE, José Raúl, GISPERT, Juan D, JIMENEZ, José, LANDOLFI, Stefania, CACI, Karina, ALLENDE, Helena

“…Within the aim of advancing precision oncology, we have generated a collection of patient-derived xenografts (PDX) characterized at the molecular level, and a…”
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DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype by Cuesta-Borràs, Estefania, Salvans, Cándida, Arqués, Oriol, Chicote, Irene, Ramírez, Lorena, Cabellos, Laia, Martínez-Quintanilla, Jordi, Mur-Espinosa, Alex, García-Álvarez, Alejandro, Hernando, Jorge, Tejedor, Juan Ramón, Mirallas, Oriol, Élez, Elena, Fraga, Mario F., Tabernero, Josep, Nuciforo, Paolo, Capdevila, Jaume, Palmer, Héctor G., Puig, Isabel

“…Tumor relapse is linked to rapid chemoresistance and represents a bottleneck for cancer therapy success. Engagement of a reduced proliferation state is a…”
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Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes by Herrero, Ana, Pinto, Adán, Colón-Bolea, Paula, Casar, Berta, Jones, Mary, Agudo-Ibáñez, Lorena, Vidal, Rebeca, Tenbaum, Stephan P., Nuciforo, Paolo, Valdizán, Elsa M., Horvath, Zoltan, Orfi, Laszlo, Pineda-Lucena, Antonio, Bony, Emilie, Keri, Gyorgy, Rivas, Germán, Pazos, Angel, Gozalbes, Rafael, Palmer, Héctor G., Hurlstone, Adam, Crespo, Piero

“…Nearly 50% of human malignancies exhibit unregulated RAS-ERK signaling; inhibiting it is a valid strategy for antineoplastic intervention. Upon activation, ERK…”
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Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer by Arqués, Oriol, Chicote, Irene, Puig, Isabel, Tenbaum, Stephan P, Argilés, Guillem, Dienstmann, Rodrigo, Fernández, Natalia, Caratù, Ginevra, Matito, Judit, Silberschmidt, Daniel, Rodon, Jordi, Landolfi, Stefania, Prat, Aleix, Espín, Eloy, Charco, Ramón, Nuciforo, Paolo, Vivancos, Ana, Shao, Wenlin, Tabernero, Josep, Palmer, Héctor G

“…Oncogenic mutations in the KRAS/PI3K/AKT pathway are one of the most frequent alterations in cancer. Although PI3K or AKT inhibitors show promising results in…”
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Advanced Colorectal Cancer Orthotopic Patient-Derived Xenograft Models for Cancer and Stem Cell Research by Chicote, Irene, Cámara, Juan Antonio, Palmer, Héctor G

“…In the recent years has being a great expansion of new preclinical models of colorectal cancer (CRC) based on patient-derived cells, from ex vivo 2D cell…”
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TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence by Puig, Isabel, Tenbaum, Stephan P, Chicote, Irene, Arqués, Oriol, Martínez-Quintanilla, Jordi, Cuesta-Borrás, Estefania, Ramírez, Lorena, Gonzalo, Pilar, Soto, Atenea, Aguilar, Susana, Eguizabal, Cristina, Caratù, Ginevra, Prat, Aleix, Argilés, Guillem, Landolfi, Stefania, Casanovas, Oriol, Serra, Violeta, Villanueva, Alberto, Arroyo, Alicia G, Terracciano, Luigi, Nuciforo, Paolo, Seoane, Joan, Recio, Juan A, Vivancos, Ana, Dienstmann, Rodrigo, Tabernero, Josep, Palmer, Héctor G

“…Dormant or slow-cycling tumor cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery and adjuvant…”
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Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies by Sveen, Anita, Bruun, Jarle, Eide, Peter W, Eilertsen, Ina A, Ramirez, Lorena, Murumägi, Astrid, Arjama, Mariliina, Danielsen, Stine A, Kryeziu, Kushtrim, Elez, Elena, Tabernero, Josep, Guinney, Justin, Palmer, Hector G, Nesbakken, Arild, Kallioniemi, Olli, Dienstmann, Rodrigo, Lothe, Ragnhild A

“…Response to standard oncologic treatment is limited in colorectal cancer. The gene expression-based consensus molecular subtypes (CMS) provide a new paradigm…”
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Pharmacological disruption of the Notch transcription factor complex by Lehal, Rajwinder, Zaric, Jelena, Vigolo, Michele, Urech, Charlotte, Frismantas, Viktoras, Zangger, Nadine, Cao, Linlin, Berger, Adeline, Chicote, Irene, Loubéry, Sylvain, Choi, Sung Hee, Koch, Ute, Blacklow, Stephen C., Palmer, Hector G., Bornhauser, Beat, González-Gaitán, Marcos, Arsenijevic, Yvan, Zoete, Vincent, Aster, Jon C., Bourquin, Jean-Pierre, Radtke, Freddy

“…Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation,…”
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β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer by Tenbaum, Stephan P, Ordóñez-Morán, Paloma, Puig, Isabel, Chicote, Irene, Arqués, Oriol, Landolfi, Stefania, Fernández, Yolanda, Herance, José Raúl, Gispert, Juan D, Mendizabal, Leire, Aguilar, Susana, Cajal, Santiago Ramón y, Schwartz, Simó, Vivancos, Ana, Espín, Eloy, Rojas, Santiago, Baselga, José, Tabernero, Josep, Muñoz, Alberto, Palmer, Héctor G

“…The crosstalk between the transcriptional activity of β-catenin and FOXO3a reveals unexpected pro-metastatic cooperative effects of these pathways through…”
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Widespread Repression of Gene Expression in Cancer by a Wnt/β-Catenin/MAPK Pathway by Harmston, Nathan, Lim, Jun Yi Stanley, Arqués, Oriol, Palmer, Héctor G, Petretto, Enrico, Virshup, David M, Madan, Babita

“…Aberrant Wnt signaling drives a number of cancers through regulation of diverse downstream pathways. Wnt/β-catenin signaling achieves this in part by…”
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Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity by Bruun, Jarle, Kryeziu, Kushtrim, Eide, Peter W, Moosavi, Seyed H, Eilertsen, Ina A, Langerud, Jonas, Røsok, Bård, Totland, Max Z, Brunsell, Tuva H, Pellinen, Teijo, Saarela, Jani, Bergsland, Christian H, Palmer, Hector G, Brudvik, Kristoffer W, Guren, Tormod, Dienstmann, Rodrigo, Guren, Marianne G, Nesbakken, Arild, Bjørnbeth, Bjørn Atle, Sveen, Anita, Lothe, Ragnhild A

“…Molecular tumor heterogeneity may have important implications for the efficacy of targeted therapies in metastatic cancers. Inter-metastatic heterogeneity of…”
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Precision Oncology and Systemic Targeted Therapy in Pseudomyxoma Peritonei by Martínez-Quintanilla, Jordi, Cabot, Débora, Sabia, Doménico, Arqués, Oriol, Vergés, Jordi, Chicote, Irene, Bijelic, Lana, Cabellos, Laia, Alcántara, Anna M, Ramos, Isabel, Barrios, Pedro, Crusellas, Oriol, Palacio, Lina M, Cámara, Juan A, Barriuso, Jorge, Jiménez, Juan J, Muñoz-Torres, Pau, Nonell, Lara, Flores, Raquel, Médico, Enzo, Guaglio, Marcello, Ros, Javier, Élez, Elena, Tabernero, Josep, Aziz, Omer, Deraco, Marcello, Palmer, Héctor G

“…Pseudomyxoma peritonei (PMP) is a rare and poorly understood malignant condition characterized by the accumulation of intra-abdominal mucin produced from…”
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Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer by Larriba, María Jesús, Ordóñez-Morán, Paloma, Chicote, Irene, Martín-Fernández, Génesis, Puig, Isabel, Muñoz, Alberto, Pálmer, Héctor G

“…Aberrant activation of the Wnt/β-catenin pathway is critical for the initiation and progression of most colon cancers. This activation provokes the…”
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CD34− Cells at the Apex of the Human Hematopoietic Stem Cell Hierarchy Have Distinctive Cellular and Molecular Signatures by Anjos-Afonso, Fernando, Currie, Erin, Palmer, Hector G., Foster, Katie E., Taussig, David C., Bonnet, Dominique

“…In addition to well-characterized CD34+ hematopoietic stem and progenitor cells (HSPCs), the human hematopoietic stem cell (HSC) hierarchy contains a rare…”
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Epigenetic EGFR Gene Repression Confers Sensitivity to Therapeutic BRAFV600E Blockade in Colon Neuroendocrine Carcinomas by Capdevila, Jaume, Arqués, Oriol, Hernández Mora, Jose Ramón, Matito, Judit, Caratù, Ginevra, Mancuso, Francesco M, Landolfi, Stefania, Barriuso, Jorge, Jimenez-Fonseca, Paula, Lopez Lopez, Carlos, Garcia-Carbonero, Rocio, Hernando, Jorge, Matos, Ignacio, Paolo, Nuciforo, Hernández-Losa, Javier, Esteller, Manel, Martínez-Cardús, Anna, Tabernero, Josep, Vivancos, Ana, Palmer, Héctor G

“…The limited knowledge of the molecular alterations that characterize poorly differentiated neuroendocrine carcinomas has limited the clinical development of…”
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The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis by Pálmer, Héctor G, Anjos-Afonso, Fernando, Carmeliet, Geert, Takeda, Hikaru, Watt, Fiona M

“…We have investigated how Wnt and vitamin D receptor signals regulate epidermal differentiation. Many epidermal genes induced by beta-catenin, including the…”
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Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer by Chicote, Irene, Martínez-Quintanilla, Jordi, Cámara, Juan Antonio, Palmer, Héctor G

“…Over the last decade, more sophisticated preclinical colorectal cancer (CRC) models have been established using patient-derived cancer cells and 3D tumoroids…”
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Solid pseudopapillary neoplasms of the pancreas are dependent on the Wnt pathway by Selenica, Pier, Raj, Nitya, Kumar, Rahul, Brown, David N., Arqués, Oriol, Reidy, Diane, Klimstra, David, Snuderl, Matija, Serrano, Jonathan, Palmer, Héctor G., Weigelt, Britta, Reis‐Filho, Jorge S., Scaltriti, Maurizio

“…Solid pseudopapillary neoplasms (SPNs) are rare and relatively indolent tumors of the pancreas. While primary SPNs can be surgically resected, there are…”
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RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells by Ordóñez-Morán, Paloma, Larriba, María Jesús, Pálmer, Héctor G, Valero, Ruth A, Barbáchano, Antonio, Duñach, Mireia, de Herreros, Antonio García, Villalobos, Carlos, Berciano, María Teresa, Lafarga, Miguel, Muñoz, Alberto

“…The active vitamin D metabolite 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃) inhibits proliferation and promotes differentiation of colon cancer cells through the…”
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