Search Results - "Palmer, CN"

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis by McLean, W H Irwin, Palmer, Colin N A, Irvine, Alan D, Terron-Kwiatkowski, Ana, Zhao, Yiwei, Liao, Haihui, Lee, Simon P, Goudie, David R, Sandilands, Aileen, Campbell, Linda E, Smith, Frances J D, O'Regan, Gráinne M, Watson, Rosemarie M, Cecil, Jo E, Bale, Sherri J, Compton, John G, DiGiovanna, John J, Fleckman, Philip, Lewis-Jones, Sue, Arseculeratne, Gehan, Sergeant, Ann, Munro, Colin S, El Houate, Brahim, McElreavey, Ken, Halkjaer, Liselotte B, Bisgaard, Hans, Mukhopadhyay, Somnath

“…Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in frequency in recent decades and now affects ∼20% of the population…”
Get full text

Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use by Hernandez-Pacheco, Natalia, Vijverberg, Susanne J, Herrera-Luis, Esther, Li, Jiang, Sio, Yang Yie, Granell, Raquel, Corrales, Almudena, Maroteau, Cyrielle, Lethem, Ryan, Perez-Garcia, Javier, Farzan, Niloufar, Repnik, Katja, Gorenjak, Mario, Soares, Patricia, Karimi, Leila, Schieck, Maximilian, Pérez-Méndez, Lina, Berce, Vojko, Tavendale, Roger, Eng, Celeste, Sardon, Olaia, Kull, Inger, Mukhopadhyay, Somnath, Pirmohamed, Munir, Verhamme, Katia M C, Burchard, Esteban G, Kabesch, Michael, Hawcutt, Daniel B, Melén, Erik, Potočnik, Uroš, Chew, Fook Tim, Tantisira, Kelan G, Turner, Steve, Palmer, Colin N, Flores, Carlos, Pino-Yanes, Maria, Maitland-van der Zee, Anke H

“…Substantial variability in response to asthma treatment with inhaled corticosteroids (ICS) has been described among individuals and populations, suggesting the…”
Get full text

Protein biomarkers for the prediction of cardiovascular disease in type 2 diabetes by Looker, Helen C., Colombo, Marco, Agakov, Felix, Zeller, Tanja, Groop, Leif, Thorand, Barbara, Palmer, Colin N., Hamsten, Anders, de Faire, Ulf, Nogoceke, Everson, Livingstone, Shona J., Salomaa, Veikko, Leander, Karin, Barbarini, Nicola, Bellazzi, Riccardo, van Zuydam, Natalie, McKeigue, Paul M., Colhoun, Helen M.

“…Aims/hypothesis We selected the most informative protein biomarkers for the prediction of incident cardiovascular disease (CVD) in people with type 2 diabetes…”
Get full text

Multi‐ancestry genome‐wide association study of asthma exacerbations by Herrera‐Luis, Esther, Ortega, Victor E., Ampleford, Elizabeth J., Sio, Yang Yie, Granell, Raquel, Roos, Emmely, Terzikhan, Natalie, Vergara, Ernesto Elorduy, Hernandez‐Pacheco, Natalia, Perez‐Garcia, Javier, Martin‐Gonzalez, Elena, Lorenzo‐Diaz, Fabian, Hashimoto, Simone, Brinkman, Paul, Jorgensen, Andrea L., Yan, Qi, Forno, Erick, Vijverberg, Susanne J., Lethem, Ryan, Espuela‐Ortiz, Antonio, Gorenjak, Mario, Eng, Celeste, González‐Pérez, Ruperto, Hernández‐Pérez, José M., Poza‐Guedes, Paloma, Sardón, Olaia, Corcuera, Paula, Hawkins, Greg A., Marsico, Annalisa, Bahmer, Thomas, Rabe, Klaus F., Hansen, Gesine, Kopp, Matthias Volkmar, Rios, Raimon, Cruz, Maria Jesus, González‐Barcala, Francisco‐Javier, Olaguibel, José María, Plaza, Vicente, Quirce, Santiago, Canino, Glorisa, Cloutier, Michelle, Pozo, Victoria, Rodriguez‐Santana, Jose R., Korta‐Murua, Javier, Villar, Jesús, Potočnik, Uroš, Figueiredo, Camila, Kabesch, Michael, Mukhopadhyay, Somnath, Pirmohamed, Munir, Hawcutt, Daniel B., Melén, Erik, Palmer, Colin N., Turner, Steve, Maitland‐van der Zee, Anke H., Mutius, Erika, Celedón, Juan C., Brusselle, Guy, Chew, Fook Tim, Bleecker, Eugene, Meyers, Deborah, Burchard, Esteban G., Pino‐Yanes, Maria

“…Background Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on…”
Get full text

17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use by Farzan, N., Vijverberg, S. J., Hernandez‐Pacheco, N., Bel, E. H. D., Berce, V., Bønnelykke, K., Bisgaard, H., Burchard, E. G., Canino, G., Celedón, J. C., Chew, F. T., Chiang, W. C., Cloutier, M. M., Forno, E., Francis, B., Hawcutt, D. B., Herrera‐Luis, E., Kabesch, M., Karimi, L., Melén, E., Mukhopadhyay, S., Merid, S. K., Palmer, C. N., Pino‐Yanes, M., Pirmohamed, M., Potočnik, U., Repnik, K., Schieck, M., Sevelsted, A., Sio, Y. Y., Smyth, R. L., Soares, P., Söderhäll, C., Tantisira, K. G., Tavendale, R., Tse, S. M., Turner, S., Verhamme, K. M., Maitland‐van der Zee, A.‐H.

Get full text

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium by Farzan, Niloufar, Vijverberg, Susanne J, Andiappan, Anand K, Arianto, Lambang, Berce, Vojko, Blanca-López, Natalia, Bisgaard, Hans, Bønnelykke, Klaus, Burchard, Esteban G, Campo, Paloma, Canino, Glorisa, Carleton, Bruce, Celedón, Juan C, Chew, Fook Tim, Chiang, Wen Chin, Cloutier, Michelle M, Daley, Denis, Den Dekker, Herman T, Dijk, F Nicole, Duijts, Liesbeth, Flores, Carlos, Forno, Erick, Hawcutt, Daniel B, Hernandez-Pacheco, Natalia, de Jongste, Johan C, Kabesch, Michael, Koppelman, Gerard H, Manolopoulos, Vangelis G, Melén, Erik, Mukhopadhyay, Somnath, Nilsson, Sara, Palmer, Colin N, Pino-Yanes, Maria, Pirmohamed, Munir, Poto nki, Uros, Raaijmakers, Jan A, Repnik, Katja, Schieck, Maximilian, Sio, Yang Yie, Smyth, Rosalind L, Szalai, Csaba, Tantisira, Kelan G, Turner, Steve, van der Schee, Marc P, Verhamme, Katia M, Maitland-van der Zee, Anke H

“…International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics…”
Get full text

Identification of ROBO2 as a Potential Locus Associated with Inhaled Corticosteroid Response in Childhood Asthma by Hernandez-Pacheco, Natalia, Gorenjak, Mario, Li, Jiang, Repnik, Katja, Vijverberg, Susanne J., Berce, Vojko, Jorgensen, Andrea, Karimi, Leila, Schieck, Maximilian, Samedy-Bates, Lesly-Anne, Tavendale, Roger, Villar, Jesús, Mukhopadhyay, Somnath, Pirmohamed, Munir, Verhamme, Katia M. C., Kabesch, Michael, Hawcutt, Daniel B., Turner, Steve, Palmer, Colin N., Tantisira, Kelan G., Burchard, Esteban G., Maitland-van der Zee, Anke H., Flores, Carlos, Potočnik, Uroš, Pino-Yanes, Maria

“…Inhaled corticosteroids (ICS) are the most common asthma controller medication. An important contribution of genetic factors in ICS response has been…”
Get full text

G153 Determinants of Quality of Life in Children with Asthma Who Live in Scotland by Turner, SW, Mehta, A, Ayres, JG, Palmer, CN, Mukhopadhyay, S

“…Background Childhood asthma is a common chronic condition which may be associated with reduced quality of life (QoL). Factors which determine QoL are important…”
Get full text

Subsequent Event Risk in Individuals With Established Coronary Heart Disease by Patel, Riyaz S, Tragante, Vinicius, Schmidt, Amand F, McCubrey, Raymond O, Holmes, Michael V, Howe, Laurence J, Direk, Kenan, Åkerblom, Axel, Leander, Karin, Virani, Salim S, Kaminski, Karol A, Muehlschlegel, Jochen D, Allayee, Hooman, Almgren, Peter, Alver, Maris, Baranova, Ekaterina V, Behloui, Hassan, Boeckx, Bram, Braund, Peter S, Breitling, Lutz P, Delgado, Graciela, Duarte, Nubia E, Dubé, Marie-Pierre, Dufresne, Line, Eriksson, Niclas, Foco, Luisa, Scholz, Markus, Gijsberts, Crystel M, Glinge, Charlotte, Gong, Yan, Hartiala, Jaana, Heydarpour, Mahyar, Hubacek, Jaroslav A, Kleber, Marcus, Kofink, Daniel, Kotti, Salma, Kuukasjärvi, Pekka, Lee, Vei-Vei, Leiherer, Andreas, Lenzini, Petra A, Levin, Daniel, Lyytikäinen, Leo-Pekka, Martinelli, Nicola, Mons, Ute, Nelson, Christopher P, Nikus, Kjell, Pilbrow, Anna P, Ploski, Rafal, Sun, Yan V, Tanck, Michael W T, Tang, W H Wilson, Trompet, Stella, van der Laan, Sander W, Van Setten, Jessica, Vilmundarson, Ragnar O, Viviani Anselmi, Chiara, Vlachopoulou, Efthymia, Al Ali, Lawien, Boerwinkle, Eric, Briguori, Carlo, Carlquist, John F, Carruthers, Kathryn F, Casu, Gavino, Deanfield, John, Deloukas, Panos, Dudbridge, Frank, Engstrøm, Thomas, Fitzpatrick, Natalie, Fox, Kim, Gigante, Bruna, James, Stefan, Lokki, Marja-Liisa, Lotufo, Paulo A, Marziliano, Nicola, Mordi, Ify R, Muhlestein, Joseph B, Newton-Cheh, Christopher, Pitha, Jan, Saely, Christoph H, Samman-Tahhan, Ayman, Sandesara, Pratik B, Teren, Andrej, Timmis, Adam, Van de Werf, Frans, Wauters, Els, Wilde, Arthur A M, Ford, Ian, Stott, David J, Algra, Ale, Andreassi, Maria G, Ardissino, Diego, Arsenault, Benoit J, Ballantyne, Christie M, Bergmeijer, Thomas O, Bezzina, Connie R, Body, Simon C, Boersma, Eric H, Bogaty, Peter, Bots, Michiel L, Brenner, Hermann

“…The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and…”
Get full text

Multi-ancestral meta-analysis yields novel genetic loci for asthma exacerbations by Luis, EH, Ortega, VE, Ampleford, EJ, Sio, YY, Granell, R, De Roos, E, Terzikhan, N, Vergara, EE, Hernandez-Pacheco, N, Perez-Garcia, J, Martin-Gonzalez, E, Lorenzo-Diaz, F, Hashimoto, S, Brinkman, P, Jorgensen, AL, Yan, Q, Forno, E, Vijverberg, SJ, Lethem, R, Espuela-Ortiz, A, Gorenjak, M, Eng, C, Gonzalez-Perez, R, Hernandez-Perez, JM, Poza-Guedes, P, Sardon, O, Corcuera, P, Hawkins, GA, Marsico, A, Bahmer, T, Rabe, KF, Hansen, G, Kopp, MV, Rios, R, Cruz, MJ, Gonzalez-Barcala, F, Olaguibel, JM, Plaza, V, Quirce, S, Canino, G, Cloutier, M, Del Pozo, V, Rodriguez-Santana, JR, Korta-Murua, J, Villar, J, Potocnik, U, Figueiredo, C, Kabesch, M, Mukhopadhyay, S, Pirmohamed, M, Hawcutt, DB, Melen, E, Palmer, CN, Turner, S, Maitland-Van der Zee, AH, Von Mutius, E, Celeclon, JC, Brusselle, G, Chew, FT, Bleecker, E, Meyers, D, Burchard, EG, Pino-Yanes, M

Get full text

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events by Patel, Riyaz S, Schmidt, Amand F, Tragante, Vinicius, McCubrey, Raymond O, Holmes, Michael V, Howe, Laurence J, Direk, Kenan, Åkerblom, Axel, Leander, Karin, Virani, Salim S, Kaminski, Karol A, Muehlschlegel, Jochen D, Dubé, Marie-Pierre, Allayee, Hooman, Almgren, Peter, Alver, Maris, Baranova, Ekaterina V, Behlouli, Hassan, Boeckx, Bram, Braund, Peter S, Breitling, Lutz P, Delgado, Graciela, Duarte, Nubia E, Dufresne, Line, Eriksson, Niclas, Foco, Luisa, Gijsberts, Crystel M, Gong, Yan, Hartiala, Jaana, Heydarpour, Mahyar, Hubacek, Jaroslav A, Kleber, Marcus, Kofink, Daniel, Kuukasjärvi, Pekka, Lee, Vei-Vei, Leiherer, Andreas, Lenzini, Petra A, Levin, Daniel, Lyytikäinen, Leo-Pekka, Martinelli, Nicola, Mons, Ute, Nelson, Christopher P, Nikus, Kjell, Pilbrow, Anna P, Ploski, Rafal, Sun, Yan V, Tanck, Michael W T, Tang, W H Wilson, Trompet, Stella, van der Laan, Sander W, van Setten, Jessica, Vilmundarson, Ragnar O, Viviani Anselmi, Chiara, Vlachopoulou, Efthymia, Boerwinkle, Eric, Briguori, Carlo, Carlquist, John F, Carruthers, Kathryn F, Casu, Gavino, Deanfield, John, Deloukas, Panos, Dudbridge, Frank, Fitzpatrick, Natalie, Gigante, Bruna, James, Stefan, Lokki, Marja-Liisa, Lotufo, Paulo A, Marziliano, Nicola, Mordi, Ify R, Muhlestein, Joseph B, Newton Cheh, Chris, Pitha, Jan, Saely, Christoph H, Samman-Tahhan, Ayman, Sandesara, Pratik B, Teren, Andrej, Timmis, Adam, Van de Werf, Frans, Wauters, Els, Wilde, Arthur A M, Ford, Ian, Stott, David J, Algra, Ale, Andreassi, Maria G, Ardissino, Diego, Arsenault, Benoit J, Ballantyne, Christie M, Bergmeijer, Thomas O, Bezzina, Connie R, Body, Simon C, Bogaty, Peter, de Borst, Gert J, Brenner, Hermann, Burkhardt, Ralph, Carpeggiani, Clara, Condorelli, Gianluigi, Cooper-DeHoff, Rhonda M, Cresci, Sharon, de Faire, Ulf, Doughty, Robert N

“…Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent…”
Get full text

17q21 gene variation increases the risk of exacerbations in asthmatic children treated with inhaled corticosteroids: A meta-analysis in the multi-ethnic pica consortium by Farzan, N, Vijverberg, SJ, Hernandez-Pacheco, N, Berce, V, Burchard, EG, Canino, G, Celedon, JC, Cloutier, MM, Forno, E, Francis, B, Hawcutt, DB, Kabesch, M, Karimi, L, Melen, E, Mukhopadhyay, S, Nilsson, S, Palmer, CN, Pino-Yanes, M, Pirmohamed, M, Potocnik, U, Raaijmakers, JA, Repnik, K, Schieck, M, Smyth, RL, Tantisira, KG, Tavendale, R, Tse, SM, Turner, S, Verhamme, KM, Maitland-Van der Zee, AH

Get full text

Role of the peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation by Johnson, E F, Palmer, C N, Griffin, K J, Hsu, M H

“…Cytochrome P450s of the 4A subfamily generally catalyze the omega-hydroxylation of fatty acids. The induction of P450 4A enzymes by peroxisome proliferators or…”
Get more information

A PPAR response element regulates transcription of the gene for human adipose differentiation-related protein by Targett-Adams, Paul, McElwee, Marion J., Ehrenborg, Ewa, Gustafsson, Mattias C., Palmer, Colin N., McLauchlan, John

“…Lipid droplets are cytoplasmic organelles which serve as storage sites for neutral lipids. Adipose differentiation-related protein (ADRP) is intrinsically…”
Get full text

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease by Nikpay, Majid, Goel, Anuj, Won, Hong-Hee, Hall, Leanne M, Willenborg, Christina, Kanoni, Stavroula, Saleheen, Danish, Kyriakou, Theodosios, Nelson, Christopher P, Hopewell, Jemma C, Webb, Thomas R, Zeng, Lingyao, Dehghan, Abbas, Alver, Maris, Armasu, Sebastian M, Auro, Kirsi, Bjonnes, Andrew, Chasman, Daniel I, Chen, Shufeng, Ford, Ian, Franceschini, Nora, Gieger, Christian, Grace, Christopher, Gustafsson, Stefan, Huang, Jie, Hwang, Shih-Jen, Kim, Yun Kyoung, Kleber, Marcus E, Lau, King Wai, Lu, Xiangfeng, Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mihailov, Evelin, Morrison, Alanna C, Pervjakova, Natalia, Qu, Liming, Rose, Lynda M, Salfati, Elias, Saxena, Richa, Scholz, Markus, Smith, Albert V, Tikkanen, Emmi, Uitterlinden, Andre, Yang, Xueli, Zhang, Weihua, Zhao, Wei, de Andrade, Mariza, de Vries, Paul S, van Zuydam, Natalie R, Anand, Sonia S, Bertram, Lars, Beutner, Frank, Dedoussis, George, Frossard, Philippe, Gauguier, Dominique, Goodall, Alison H, Gottesman, Omri, Haber, Marc, Han, Bok-Ghee, Huang, Jianfeng, Jalilzadeh, Shapour, Kessler, Thorsten, König, Inke R, Lannfelt, Lars, Lieb, Wolfgang, Lind, Lars, Lindgren, Cecilia M, Lokki, Marja-Liisa, Magnusson, Patrik K, Mallick, Nadeem H, Mehra, Narinder, Meitinger, Thomas, Memon, Fazal-Ur-Rehman, Morris, Andrew P, Nieminen, Markku S, Pedersen, Nancy L, Peters, Annette, Rallidis, Loukianos S, Rasheed, Asif, Samuel, Maria, Shah, Svati H, Sinisalo, Juha, Stirrups, Kathleen E, Trompet, Stella, Wang, Laiyuan, Zaman, Khan S, Ardissino, Diego, Boerwinkle, Eric, Borecki, Ingrid B, Bottinger, Erwin P, Buring, Julie E, Chambers, John C, Collins, Rory, Cupples, L Adrienne, Danesh, John, Demuth, Ilja, Elosua, Roberto, Epstein, Stephen E, Esko, Tõnu, Feitosa, Mary F

“…Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of…”
Get full text

Elevated expression of the genes encoding TNF-[alpha] and thromboxane synthase in leucocytes from patients with systemic sclerosis by Young, V, M. Ho, Vosper, H, Belch, J J F, Palmer, C N A

“…Objective. To determine the expression of molecular markers of prostanoid/fatty acid signalling in leucocytes of patients with systemic sclerosis (SSc)…”
Get full text

Dolabelladienetriol, a compound from Dictyota pfaffii algae, inhibits the infection by Leishmania amazonensis by Soares, Deivid Costa, Calegari-Silva, Teresa C, Lopes, Ulisses G, Teixeira, Valéria L, de Palmer Paixão, Izabel C N, Cirne-Santos, Claudio, Bou-Habib, Dumith Chequer, Saraiva, Elvira M

“…Chemotherapy for leishmaniasis, a disease caused by Leishmania parasites, is expensive and causes side effects. Furthermore, parasite resistance constitutes an…”
Get full text

Positives of the Ghetto by Palmer, Cecelia N.

Get full text

Educating for the Environment by Palmer, Christopher N, Muscara, Carol

“…The crisis in American education is converging with an equally significant concern: the unchecked destruction of our natural environment. Through its Science…”
Get full text