Search Results - "Palmblad, Karin"

Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis by Agalave, Nilesh M., Larsson, Max, Abdelmoaty, Sally, Su, Jie, Baharpoor, Azar, Lundbäck, Peter, Palmblad, Karin, Andersson, Ulf, Harris, Helena, Svensson, Camilla I.

“…Spinal injection of disulfide extracellular high mobility group box-1 protein (HMGB1) induces mechanical hypersensitivity and spinal glial activation, and…”
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critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release by Yang, Huan, Hreggvidsdottir, Hulda S, Palmblad, Karin, Wang, Haichao, Ochani, Mahendar, Li, Jianhua, Lu, Ben, Chavan, Sangeeta, Rosas-Ballina, Mauricio, Al-Abed, Yousef, Akira, Shizuo, Bierhaus, Angelika, Erlandsson-Harris, Helena, Andersson, Ulf, Tracey, Kevin J

“…During infection, vertebrates develop "sickness syndrome," characterized by fever, anorexia, behavioral withdrawal, acute-phase protein responses, and…”
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A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug‐induced liver injury and postinjury inflammation in mice by Lundbäck, Peter, Lea, Jonathan D., Sowinska, Agnieszka, Ottosson, Lars, Fürst, Camilla Melin, Steen, Johanna, Aulin, Cecilia, Clarke, Joanna I., Kipar, Anja, Klevenvall, Lena, Yang, Huan, Palmblad, Karin, Park, B. Kevin, Tracey, Kevin J., Blom, Anna M., Andersson, Ulf, Antoine, Daniel J., Erlandsson Harris, Helena

“…Acetaminophen (APAP) overdoses are of major clinical concern. Growing evidence underlines a pathogenic contribution of sterile postinjury inflammation in…”
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The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation by Hreggvidsdottir, Hulda Sigridur, Ostberg, Therese, Wähämaa, Heidi, Schierbeck, Hanna, Aveberger, Ann-Charlotte, Klevenvall, Lena, Palmblad, Karin, Ottosson, Lars, Andersson, Ulf, Harris, Helena Erlandsson

“…A prototypic mechanism for enhancement of inflammation by an endogenous molecule is described. The nuclear protein HMGB1 has previously been demonstrated to…”
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Therapeutic administration of etoposide coincides with reduced systemic HMGB1 levels in macrophage activation syndrome by Palmblad, Karin, Schierbeck, Hanna, Sundberg, Erik, Horne, Anna-Carin, Erlandsson Harris, Helena, Henter, Jan-Inge, Andersson, Ulf

“…Macrophage activation syndrome (MAS) is a potentially fatal complication of systemic inflammation. HMGB1 is a nuclear protein released extracellularly during…”
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TLR4 as receptor for HMGB1 induced muscle dysfunction in myositis by Zong, Mei, Bruton, Joseph D, Grundtman, Cecilia, Yang, Huan, Li, Jian Hua, Alexanderson, Helene, Palmblad, Karin, Andersson, Ulf, Harris, Helena E, Lundberg, Ingrid E, Westerblad, Håkan

“…Polymyositis and dermatomyositis are characterised by muscle weakness and fatigue even in patients with normal muscle histology via unresolved pathogenic…”
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Monoclonal anti-HMGB1 (high mobility group box chromosomal protein 1) antibody protection in two experimental arthritis models by Schierbeck, Hanna, Lundbäck, Peter, Palmblad, Karin, Klevenvall, Lena, Erlandsson-Harris, Helena, Andersson, Ulf, Ottosson, Lars

“…High mobility group box chromosomal protein 1 (HMGB1) is a DNA-binding nuclear protein that can be released from dying cells and activated myeloid cells…”
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Retraction Note to: High systemic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome by Palmblad, Karin, Schierbeck, Hanna, Sundberg, Erik, Horne, Anna-Carin, Harris, Helena Erlandsson, Henter, Jan-Inge, Antoine, Daniel J, Andersson, Ulf

“…This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s10020-020-00263-2…”
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Expression of concern to: High systematic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome by Palmblad, Karin, Schierbeck, Hanna, Sundberg, Erik, Horne, Anna-Carin, Harris, Helena Erlandsson, Henter, Jan-Inge, Antoine, Daniel J., Andersson, Ulf

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Benefits of a Juvenile Arthritis Support Program (JASP-1) for children recently diagnosed with Juvenile Idiopathic Arthritis and their parents by Mördrup, Karina, Jungner, Johanna Granhagen, Broström, Eva, Palmblad, Karin, Bartholdson, Cecilia

“…Medical treatment for children with Juvenile Idiopathic Arthritis (JIA) has improved radically since the development of biological disease-modifying…”
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Immunoprofiling of active and inactive systemic juvenile idiopathic arthritis reveals distinct biomarkers: a single-center study by Qu, Heshuang, Sundberg, Erik, Aulin, Cecilia, Neog, Manoj, Palmblad, Karin, Horne, Anna Carin, Granath, Fredrik, Ek, Alexandra, Melén, Erik, Olsson, Mia, Harris, Helena Erlandsson

“…This study aimed to perform an immunoprofiling of systemic juvenile idiopathic arthritis (sJIA) in order to define biomarkers of clinical use as well as reveal…”
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High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes by Andersson, U, Wang, H, Palmblad, K, Aveberger, A C, Bloom, O, Erlandsson-Harris, H, Janson, A, Kokkola, R, Zhang, M, Yang, H, Tracey, K J

“…Lipopolysaccharide (LPS) is lethal to animals because it activates cytokine release, causing septic shock and tissue injury. Early proinflammatory cytokines…”
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High systemic levels of the cytokine-inducing HMGB1 isoform secreted in severe macrophage activation syndrome by Palmblad, Karin, Schierbeck, Hanna, Sundberg, Erik, Horne, Anna-Carin, Harris, Helena Erlandsson, Henter, Jan-Inge, Antoine, Daniel J, Andersson, Ulf

“…Macrophage activation syndrome (MAS) is a potentially fatal complication of systemic inflammation. High mobility group box 1 (HMGB1) is a nuclear protein…”
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novel inflammatory cytokine high mobility group box protein 1 (HMGB1) is expressed by human term placenta by Holmlund, Ulrika, Wähämaa, Heidi, Bachmayer, Nora, Bremme, Katarina, Sverremark-Ekström, Eva, Palmblad, Karin

“…High mobility group box protein 1 (HMGB1) was previously considered a strict nuclear protein, but lately data are accumulating on its extranuclear functions…”
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Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis by Ostberg, Therese, Wähämaa, Heidi, Palmblad, Karin, Ito, Norimasa, Stridh, Pernilla, Shoshan, Maria, Lotze, Michael T, Harris, Helena Erlandsson, Andersson, Ulf

“…High mobility group box chromosomal protein 1 (HMGB1) is a nuclear protein that acts as a pro-inflammatory mediator following extracellular release. The…”
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Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis by Palmblad, Karin, Sundberg, Erik, Diez, Margarita, Söderling, Riikka, Aveberger, Ann-Charlotte, Andersson, Ulf, Harris, Helena Erlandsson

“…High-mobility group chromosomal box protein 1 (HMGB1) is a structural nuclear protein that promotes inflammation when present extracellularly. Aberrant,…”
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Normalized Interferon Signatures and Clinical Improvements by IFNAR1 Blocking Antibody (Anifrolumab) in Patients with Type I Interferonopathies by Kretzschmar, Genia, Páez, Laura Piñero, Tan, Ziyang, Wang, Jun, Gonzalez, Laura, Mugabo, Constantin Habimana, Johnsson, Anette, Chen, Yang, Mikeš, Jaromír, Lakshmikanth, Tadepally, James, Anna, Goldbach-Mansky, Raphaela, Fischer, Marie, Palmblad, Karin, Alehashemi, Sara, Horne, AnnaCarin, Brodin, Petter

“…Purpose A causal role of type-I interferons (IFN-I) in autoinflammatory type-I interferonopathies such as SAVI (STING–associated vasculopathy with onset in…”
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High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts by Wähämaa, Heidi, Schierbeck, Hanna, Hreggvidsdottir, Hulda S, Palmblad, Karin, Aveberger, Anne-Charlotte, Andersson, Ulf, Harris, Helena Erlandsson

“…In addition to its direct proinflammatory activity, extracellular high mobility group box protein 1 (HMGB1) can strongly enhance the cytokine response evoked…”
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Population‐based study of multisystem inflammatory syndrome associated with COVID‐19 found that 36% of children had persistent symptoms by Kahn, Robin, Berg, Stefan, Berntson, Lillemor, Berthold, Elisabet, Brodin, Petter, Bäckström, Fredrik, Compagno, Michele, Fasth, Anders, Lingman Framme, Jenny, Horne, AnnaCarin, Hätting, Josefin, Król, Petra, Kukka, Antti J, Mossberg, Maria, Månsson, Bengt, Nordenhäll, Charlotta, Idring Nordström, Selma, Khammari Nyström, Fatine, Palmblad, Karin, Rasti, Reza, Rudolph, André, Rydenman, Karin, Sundberg, Erik, Säve‐Söderbergh, Eva, Altman, Maria

“…Aim Our aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS‐C) associated with COVID‐19. Methods This national,…”
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Comparison of EULAR/PRINTO/PReS Ankara 2008 and 2022 ACR/EULAR classification criteria for granulomatosis with polyangiitis in children by Kaya Akca, Ummusen, Batu, Ezgi Deniz, Jelusic, Marija, Calatroni, Marta, Bakry, Reima, Frkovic, Marijan, Vinšová, Nikol, Campos, Reinan T, Horne, AnnaCarin, Caglayan, Sengul, Vaglio, Augusto, Moroni, Gabriella, Emmi, Giacomo, Ghiggeri, Gian Marco, Koker, Oya, Sinico, Renato Alberto, Kim, Susan, Gagro, Alenka, Matucci-Cerinic, Caterina, Çomak, Elif, Ekici Tekin, Zahide, Arslanoglu Aydin, Elif, Heshin-Bekenstein, Merav, Acar, Banu Celikel, Gattorno, Marco, Akman, Sema, Sozeri, Betul, Palmblad, Karin, Al-Mayouf, Sulaiman M, Silva, Clovis Artur, Doležalová, Pavla, Merkel, Peter A, Ozen, Seza

“…Abstract Objective Granulomatosis with polyangiitis (GPA) is an ANCA-associated vasculitis. The 2022 ACR/EULAR-endorsed classification criteria for GPA was…”
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