Search Results - "Palma, Norma A."

Comprehensive genomic profiling of inflammatory breast cancer cases reveals a high frequency of clinically relevant genomic alterations by Ross, Jeffrey S., Ali, Siraj M., Wang, Kai, Khaira, Depinder, Palma, Norma A., Chmielecki, Juliann, Palmer, Gary A., Morosini, Deborah, Elvin, Julia A., Fernandez, Sandra V., Miller, Vincent A., Stephens, Philip J., Cristofanilli, Massimo

“…Inflammatory breast cancer (IBC) is a distinct clinicopathologic entity that carries a worse prognosis relative to non-IBC breast cancer even when matched for…”
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Prospective Comprehensive Genomic Profiling of Advanced Gastric Carcinoma Cases Reveals Frequent Clinically Relevant Genomic Alterations and New Routes for Targeted Therapies by Ali, Siraj M., Sanford, Eric M., Klempner, Samuel J., Rubinson, Douglas A., Wang, Kai, Palma, Norma A., Chmielecki, Juliann, Yelensky, Roman, Palmer, Gary A., Morosini, Deborah, Lipson, Doron, Catenacci, Daniel V., Braiteh, Fadi, Erlich, Rachel, Stephens, Philip J., Ross, Jeffrey S., Ou, Sai‐Hong Ignatius, Miller, Vincent A.

“…Background. Gastric cancer (GC) is a major global cancer burden and the second most common cause of global cancer‐related deaths. The addition of anti‐ERBB2…”
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Durable Response to Crizotinib in a MET-Amplified, KRAS-Mutated Carcinoma of Unknown Primary by Palma, Norma A., Ali, Siraj M., O'Connor, Jamie, Dutta, Deepa, Wang, Kai, Soman, Salil, Palmer, Gary A., Morosini, Deborah, Ross, Jeffrey S., Lipson, Doron, Stephens, Phil J., Patel, Mayur, Miller, Vincent A., Koutrelakos, Nicholas

“…Background: Carcinoma of unknown primary (CUP) accounts for 3-5% of all adult solid tumors. An extensive search for the anatomic site of origin is often…”
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Characterization of Clinical Cases of Collecting Duct Carcinoma of the Kidney Assessed by Comprehensive Genomic Profiling by Pal, Sumanta K, Choueiri, Toni K, Wang, Kai, Khaira, Depinder, Karam, Jose A, Van Allen, Eliezer, Palma, Norma A, Stein, Mark N, Johnson, Adrienne, Squillace, Rachel, Elvin, Julia A, Chmielecki, Juliann, Yelensky, Roman, Yakirevich, Evgeny, Lipson, Doron, Lin, Douglas I, Miller, Vincent A, Stephens, Philip J, Ali, Siraj M, Ross, Jeffrey S

“…Abstract Background Collecting duct carcinoma (CDC) is a rare type of renal cell carcinoma (RCC) originating from the renal medulla. Clinical outcomes are…”
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A Poorly Differentiated Malignant Neoplasm Lacking Lung Markers Harbors an EML4-ALK Rearrangement and Responds to Crizotinib by Chung, Jon H., Ali, Siraj M., Davis, Jenni, Robstad, Karl, McNally, Richard, Gay, Laurie M., Erlich, Rachel L., Palma, Norma A., Stephens, Phil J., Miller, Vincent A., Cutugno, Alfonso, Ross, Jeffrey S.

“…Suspected metastatic site lesions that are poorly differentiated present a diagnostic challenge when morphologic and immunohistochemical profiling cannot…”
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Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations by Ali, Siraj M., Pal, Sumanta K., Wang, Kai, Palma, Norma A., Sanford, Eric, Bailey, Mark, He, Jie, Elvin, Julia A., Chmielecki, Juliann, Squillace, Rachel, Dow, Edward, Morosini, Deborah, Buell, Jamie, Yelensky, Roman, Lipson, Doron, Frampton, Garrett M., Howley, Peter, Ross, Jeffrey S., Stephens, Philip J., Miller, Vincent A.

“…Background. Advanced penile squamous cell carcinoma (PSCC) is associated with poor survival due to the aggressiveness of the disease and lack of effective…”
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Clinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers by Hirshfield, Kim M., Tolkunov, Denis, Zhong, Hua, Ali, Siraj M., Stein, Mark N., Murphy, Susan, Vig, Hetal, Vazquez, Alexei, Glod, John, Moss, Rebecca A., Belyi, Vladimir, Chan, Chang S., Chen, Suzie, Goodell, Lauri, Foran, David, Yelensky, Roman, Palma, Norma A., Sun, James X., Miller, Vincent A., Stephens, Philip J., Ross, Jeffrey S., Kaufman, Howard, Poplin, Elizabeth, Mehnert, Janice, Tan, Antoinette R., Bertino, Joseph R., Aisner, Joseph, DiPaola, Robert S., Rodriguez‐Rodriguez, Lorna, Ganesan, Shridar

“…Background. The frequency with which targeted tumor sequencing results will lead to implemented change in care is unclear. Prospective assessment of the…”
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Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer by Young, Christian D., Zimmerman, Lisa J., Hoshino, Daisuke, Formisano, Luigi, Hanker, Ariella B., Gatza, Michael L., Morrison, Meghan M., Moore, Preston D., Whitwell, Corbin A., Dave, Bhuvanesh, Stricker, Thomas, Bhola, Neil E., Silva, Grace O., Patel, Premal, Brantley-Sieders, Dana M., Levin, Maren, Horiates, Marina, Palma, Norma A., Wang, Kai, Stephens, Philip J., Perou, Charles M., Weaver, Alissa M., O'Shaughnessy, Joyce A., Chang, Jenny C., Park, Ben Ho, Liebler, Daniel C., Cook, Rebecca S., Arteaga, Carlos L.

“…Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K) have been shown to transform human mammary epithelial…”
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Tu1711 A RANDOMIZED, DOUBLE-BLIND STUDY TO EVALUATE THE SAFETY AND TOLERABILITY OF KB174, A NOVEL SYNTHETIC GLYCAN, IN PATIENTS WITH WELL-COMPENSATED CIRRHOSIS by Bhandari, Bal R., Cehelsky, Jeffrey, Zheng, Yan, Palma, Norma A., Wingertzahn, Mark, Mittleman, Robert S.

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Tu1724 KB174 REDUCES RELATIVE ABUNDANCE OF MULTIDRUG RESISTANT (MDR) ENTEROBACTERIACEAE IN FECAL SAMPLES FROM PATIENTS WITH CIRRHOSIS IN AN EX VIVO TEST SYSTEM by Bajaj, Jasmohan S., Miller, Kelsey, Lawrence, Jonathan F., Tan, Jie, Palma, Norma A., LeBlanc, Gabrielle, Yatsunenko, Tanya

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Abstract B010: Response to treatment with nab -sirolimus among patients with primary uterine tumors: A subgroup analysis from AMPECT by Ravi, Vinod, Dickson, Mark A., Ganjoo, Kristin, Ding, Li, Schmid, Anita N., Palma, Norma A., Navarro, Willis H., Wagner, Andrew J.

“…Abstract Introduction/objective: AMPECT (NCT02494570) is a pivotal study of nab-sirolimus in patients with malignant perivascular epithelioid cell tumors…”
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Abstract P6-14-02: Genomic profiling by FoundationOne® analysis of inflammatory breast cancer cases reveals a high frequency of clinically relevant genomic alterations (GA) by Palma, Norma A, Ali, Siraj M, Wang, Kai, Chmeleiki, Juliann, Palmer, Gary, Morosini, Deborah, Ross, Jeffrey S, Miller, Vincent A, Stephens, Phil J, Cristofannilli, Massimo

“…Abstract Background: Inflammatory breast cancer (IBC) is a distinct clinicopathologic entity that carries a worse prognosis relative to non-IBC breast cancer…”
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Abstract P2-03-06: FoundationOne profiling of TSC1 and TSC2-mutated advanced breast cancers by Palma, Norma A, Chmielecki, Juliann, Frampton, Garrett, Ali, Siraj, Levin, Maren, Ross, Jeffrey S, Morosini, Deborah, Palmer, Gary, Miller, Vincent A, Stephens, Phil, O'Shaughnessy, Joyce

“…Abstract Background: The TSC1/TSC2 complex inhibits the mTOR pathway. Loss of function of this complex leads to hyperperactivation of the mTOR pathway which…”
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Abstract PD6-5: Profiling of ESR1-mutated metastatic breast cancers by FoundationOne® allows a broad genomic understanding for potential clinical implications by Palma, Norma A, Ali, Siraj, Frampton, Garrett, Wang, Kai, Gilmore, Hannah, Peguero, Julio, Harris, Lyndsay N, Cristofanilli, Massimo, Chmielecki, Juliann, Ross, Jeffrey S, Morosini, Deborah, Miller, Vincent A, Stephens, Phil J, Palmer, Gary, O'Shaughnessy, Joyce

“…Abstract Background: Estrogen receptor (ER) inhibition is an important treatment option for advanced breast cancer (BC) pts. Recent studies describe recurring…”
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GE-04COMPREHENSIVE GENOMIC PROFILING (CGP) OF PEDIATRIC GLIOMAS REVEALS A HIGH FREQUENCY OF CLINICALLY RELEVANT GENOMIC ALTERATIONS (CRGA) ASSOCIATED WITH BENEFIT FROM TARGETED THERAPY by Chalmers, Zachary R., Ali, Siraj M., Frampton, Garrett M., Chmielecki, Juliann, Palma, Norma A., Elvin, Julia A., Johnson, Adrienne, Yelensky, Roman, Ross, Jeffery S., Stephens, Phillip J., Miller, Vincent A., Waanders, Angela J., Crawford, John

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A Poorly Differentiated Malignant Neoplasm Lacking Lung Markers Harbors an EML4-ALK Rearrangement and Responds to Crizotinib by Chung, Jon H, Ali, Siraj M, Davis, Jenni, Robstad, Karl, McNally, Richard, Gay, Laurie M, Erlich, Rachel L, Palma, Norma A, Stephens, Phil J, Miller, Vincent A, Cutugno, Alfonso, Ross, Jeffrey S

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Durable Response to Crizotinib in a MET-Amplified, KRAS-Mutated Carcinoma of Unknown Primary by Palma, Norma A, Ali, Siraj M, O'Connor, Jamie, Dutta, Deepa, Wang, Kai, Soman, Salil, Palmer, Gary A, Morosini, Deborah, Ross, Jeffrey S, Lipson, Doron, Stephens, Phil J, Patel, Mayur, Miller, Vincent A, Koutrelakos, Nicholas

“…BACKGROUNDCarcinoma of unknown primary (CUP) accounts for 3-5% of all adult solid tumors. An extensive search for the anatomic site of origin is often…”
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