Search Results - "Palma, Flavio R"

Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch by Palma, Flavio R, He, Chenxia, Danes, Jeanne M, Paviani, Veronica, Coelho, Diego R, Gantner, Benjamin N, Bonini, Marcelo G

“…Reactive oxygen species (ROS) are now widely recognized as central mediators of cell signaling. Mitochondria are major sources of ROS. It is now clear that…”
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Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance by Palma, Flavio R., Coelho, Diego R., Pulakanti, Kirthi, Sakiyama, Marcelo J., Huang, Yunping, Ogata, Fernando T., Danes, Jeanne M., Meyer, Alison, Furdui, Cristina M., Spitz, Douglas R., Gomes, Ana P., Gantner, Benjamin N., Rao, Sridhar, Backman, Vadim, Bonini, Marcelo G.

“…Chromatin structure is regulated through posttranslational modifications of histone variants that modulate transcription. Although highly homologous, histone…”
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Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance by Palma, Flavio R., Coelho, Diego R., Pulakanti, Kirthi, Sakiyama, Marcelo J., Huang, Yunping, Ogata, Fernando T., Danes, Jeanne M., Meyer, Alison, Furdui, Cristina M., Spitz, Douglas R., Gomes, Ana P., Gantner, Benjamin N., Rao, Sridhar, Backman, Vadim, Bonini, Marcelo G.

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SOCS1 regulates a subset of NFκB-target genes through direct chromatin binding and defines macrophage functional phenotypes by Coelho, Diego R., Palma, Flavio R., Paviani, Veronica, LaFond, Katy M., Huang, Yunping, Wang, Dongmei, Wray, Brian, Rao, Sridhar, Yue, Feng, Bonini, Marcelo G., Gantner, Benjamin N.

“…Suppressor of cytokine signaling-1 (SOCS1) exerts control over inflammation by targeting p65 nuclear factor-κB (NF-κB) for degradation in addition to its…”
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ROS production by mitochondria: function or dysfunction? by Palma, Flavio R., Gantner, Benjamin N., Sakiyama, Marcelo J., Kayzuka, Cezar, Shukla, Sanjeev, Lacchini, Riccardo, Cunniff, Brian, Bonini, Marcelo G.

“…In eukaryotic cells, ATP generation is generally viewed as the primary function of mitochondria under normoxic conditions. Reactive oxygen species (ROS), in…”
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Arsenic and other metals as phenotype driving electrophiles in carcinogenesis by Danes, Jeanne M., Palma, Flavio R., Bonini, Marcelo G.

“…There are several sources of heavy metal exposures whether occupational or environmental. These are connected both with the existence of natural reservoirs of…”
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Histone oxidation as a new mechanism of metabolic control over gene expression by Gantner, Benjamin N., Palma, Flavio R., Kayzuka, Cezar, Lacchini, Riccardo, Foltz, Daniel R., Backman, Vadim, Kelleher, Neil, Shilatifard, Ali, Bonini, Marcelo G.

“…Histone oxidation provides a direct link between metabolically generated reactive oxygen species (ROS) and chromatin architectural changes enabling the…”
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Nuclear-localized, iron-bound superoxide dismutase-2 antagonizes epithelial lineage programs to promote stemness of breast cancer cells via a histone demethylase activity by Coelho, Diego R, Palma, Flavio R, Paviani, Veronica, He, Chenxia, Danes, Jeanne M, Huang, Yunping, Calado, Juliana C P, Hart, Peter C, Furdui, Cristina M, Poole, Leslie B, Schipma, Matthew J, Bonini, Marcelo G

“…The dichotomous behavior of superoxide dismutase-2 (SOD2) in cancer biology has long been acknowledged and more recently linked to different posttranslational…”
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Absence of Gem1 (mammalian Miro/Rhot) mitigates alpha-synuclein toxicity in a yeast model of Parkinson's disease by Melo, Thaiany Q., Palma, Flavio R., Gomes, Fernando, Netto, Luis E.S., Ferrari, Merari F.R.

“…Alpha-synuclein aggregation is a hallmark of Parkinson's disease (PD). Mutants A30P and A53T alpha-synuclein are known to exacerbate the toxicity of…”
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Inorganic arsenic promotes luminal to basal transition and metastasis of breast cancer by Danes, Jeanne M., Abreu, Andre L. P., Kerketta, Romica, Huang, Yunping, Palma, Flavio R., Gantner, Benjamin N., Mathison, Angela J., Urrutia, Raul A., Bonini, Marcelo G.

“…Inorganic arsenic (iAs/As2O32−) is an environmental toxicant found in watersheds around the world including in densely populated areas. iAs is a class I…”
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AMPK-deficiency forces metformin-challenged cancer cells to switch from carbohydrate metabolism to ketogenesis to support energy metabolism by Palma, Flavio R., Ratti, Bianca A., Paviani, Veronica, Coelho, Diego R., Miguel, Rodrigo, Danes, Jeanne M., Zaichik, Sofia V., de Abreu, Andre L., Silva, Sueli O., Chen, Yiliang, Silverstein, Roy L., Karan, Uppal, Jones, Dean P., Bonini, Marcelo G.

“…Epidemiologic studies in diabetic patients as well as research in model organisms have indicated the potential of metformin as a drug candidate for the…”
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Management of strawberry anthracnose by choice of irrigation system, mulching material and host resistance by Coelho, Marcus V.S, Palma, Flavio R, Cafe-Filho, Adalberto C

“…We studied, by means of field experiments, the combined effects of irrigation system, mulching material and genetic resistance on the incidence of strawberry…”
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Abstract 444: Lipid exposure re-wires cellular metabolism away from glycolysis toward the serine pathway conferring oncogenic properties to non-transformed breast cells by Eduardo, Mariana Bustamante, Cottone, Gannon, Liu, Shiyu, Palma, Flavio R., Zappia, Maria Paula, Islam, Abul B.M.M.K., Benevolenskaya, Elizaveta V., Frolov, Maxim V., Locasale, Jason, Bonini, Marcelo G., Chandel, Navdeep S., Khan, Seema, Clare, Susan

“…Abstract Introduction. A lipid metabolism gene signature is associated with the risk of estrogen negative breast cancer (ER-BC). In vitro, lipid exposure…”
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