Search Results - "Palma, Benedetta Dalla"

Mechanism of Action of Bortezomib and the New Proteasome Inhibitors on Myeloma Cells and the Bone Microenvironment: Impact on Myeloma-Induced Alterations of Bone Remodeling by Aversa, Franco, Dalla Palma, Benedetta, Bolzoni, Marina, Toscani, Denise, Accardi, Fabrizio, Giuliani, Nicola

“…Multiple myeloma (MM) is characterized by a high capacity to induce alterations in the bone remodeling process. The increase in osteoclastogenesis and the…”
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Monoclonal and Bispecific Anti-BCMA Antibodies in Multiple Myeloma by Dalla Palma, Benedetta, Marchica, Valentina, Catarozzo, Maria Teresa, Giuliani, Nicola, Accardi, Fabrizio

“…B-cell maturation antigen (BCMA), a member of the tumor necrosis factor receptor superfamily, is universally expressed by normal and neoplastic plasma cells…”
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The transcriptomic profile of CD138 + cells from patients with early progression from smoldering to active multiple myeloma remains substantially unchanged by Storti, Paola, Agnelli, Luca, Palma, Benedetta Dalla, Todoerti, Katia, Marchica, Valentina, Accardi, Fabrizio, Sammarelli, Gabriella, Deluca, Federica, Toscani, Denise, Costa, Federica, Vicario, Emanuela, Todaro, Giannalisa, Martella, Eugenia, Neri, Antonino, Giuliani, Nicola

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Bone Marrow CX3CL1/Fractalkine is a New Player of the Pro-Angiogenic Microenvironment in Multiple Myeloma Patients by Marchica, Valentina, Toscani, Denise, Corcione, Anna, Bolzoni, Marina, Storti, Paola, Vescovini, Rosanna, Ferretti, Elisa, Dalla Palma, Benedetta, Vicario, Emanuela, Accardi, Fabrizio, Mancini, Cristina, Martella, Eugenia, Ribatti, Domenico, Vacca, Angelo, Pistoia, Vito, Giuliani, Nicola

“…C-X3-C motif chemokine ligand 1 (CX3CL1)/fractalkine is a chemokine released after cleavage by two metalloproteases, ADAM metallopeptidase domain 10 (ADAM10)…”
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Novel Approaches to Improve Myeloma Cell Killing by Monoclonal Antibodies by Storti, Paola, Costa, Federica, Marchica, Valentina, Burroughs-Garcia, Jessica, dalla Palma, Benedetta, Toscani, Denise, Eufemiese, Rosa Alba, Giuliani, Nicola

“…The monoclonal antibodies (mAbs) have significantly changed the treatment of multiple myeloma (MM) patients. However, despite their introduction, MM remains an…”
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New Insights into Osteogenic and Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells and Their Potential Clinical Applications for Bone Regeneration in Pediatric Orthopaedics by Lisignoli, Gina, Giuliani, Nicola, Magnani, Marina, Racano, Costantina, Bolzoni, Marina, Dalla Palma, Benedetta, Spolzino, Angelica, Manferdini, Cristina, Abati, Caterina, Toscani, Denise, Facchini, Andrea, Aversa, Franco

“…Human mesenchymal stem cells (hMSCs) are pluripotent adult stem cells capable of being differentiated into osteoblasts, adipocytes, and chondrocytes. The…”
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CD38 expression by plasma cells in extramedullary multiple myeloma by Notarfranchi, Laura, Accardi, Fabrizio, Mancini, Cristina, Martella, Eugenia, Bonomini, Sabrina, Segreto, Roberta, Vescovini, Rosanna, Palma, Anna Benedetta Dalla, Sammarelli, Gabriella, Todaro, Giannalisa, Storti, Paola, Burroughs-Garcia, Jessica, Iannozzi, Nicolas Thomas, Raimondi, Vincenzo, Lungu, Oxana, Ricci, Stefania, Craviotto, Luisa, Giuliani, Nicola

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Identification of clinical‐biological features of newly diagnosed early relapse multiple myeloma patients eligible for autologous stem cell transplantation by Cillo, Lorenzo, Palma, Anna Benedetta Dalla, Ricci, Stefania, Pedrazzoni, Mario, Scita, Matteo, Bernardi, Matia, Sammarelli, Gabriella, Pelagatti, Laura, Giuliani, Nicola

“…A portion of multiple myeloma (MM) patients relapse early or do not respond to first line treatment. Identification of possible clinical and or biological…”
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CD38 Expression by Myeloma Cells and Its Role in the Context of Bone Marrow Microenvironment: Modulation by Therapeutic Agents by Costa, Federica, Dalla Palma, Benedetta, Giuliani, Nicola

“…In the last decades CD38 has emerged as an attractive target for multiple myeloma (MM). CD38 is a novel multifunctional glycoprotein that acts as a receptor,…”
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Lenalidomide increases human dendritic cell maturation in multiple myeloma patients targeting monocyte differentiation and modulating mesenchymal stromal cell inhibitory properties by Costa, Federica, Vescovini, Rosanna, Bolzoni, Marina, Marchica, Valentina, Storti, Paola, Toscani, Denise, Accardi, Fabrizio, Notarfranchi, Laura, Dalla Palma, Benedetta, Manferdini, Cristina, Manni, Sabrina, Todaro, Giannalisa, Lisignoli, Gina, Piazza, Francesco, Aversa, Franco, Giuliani, Nicola

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A Rare Case of Systemic AL Amyloidosis with Muscle Involvement: A Misleading Diagnosis by Notarfranchi, Laura, Aversa, Franco, Pietrini, Vladimiro, Cenacchi, Giovanna, Giuliani, Nicola, Costa, Roberta, Martella, Eugenia, Mancini, Cristina, Verga, Laura, Capello, Gian Luca, Capozzi, Anna Rita, Papa, Valentina, Accardi, Fabrizio, Dalla Palma, Benedetta

“…Muscle involvement in AL amyloidosis is a rare condition, and the diagnosis of amyloid myopathy is often delayed and underdiagnosed. Amyloid myopathy may be…”
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Neurofibromatosis type I and multiple myeloma coexistence: A possible link? by Accardi, Fabrizio, Marchica, Valentina, Mancini, Cristina, Maredi, Elena, Racano, Costantina, Notarfranchi, Laura, Martorana, Davide, Storti, Paola, Martella, Eugenia, Palma, Benedetta Dalla, Craviotto, Luisa, Filippo, Massimo De, Percesepe, Antonio, Aversa, Franco, Giuliani, Nicola

“…The association between Neurofibromatosis type I (NF1) and multiple myeloma (MM), a plasma cell, dyscrasia is very rare. Here we put to the attention of the…”
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CD14+CD16+ monocytes are involved in daratumumab‐mediated myeloma cells killing and in anti‐CD47 therapeutic strategy by Storti, Paola, Vescovini, Rosanna, Costa, Federica, Marchica, Valentina, Toscani, Denise, Dalla Palma, Benedetta, Craviotto, Luisa, Malavasi, Fabio, Giuliani, Nicola

“…Summary A deep elucidation of the mechanisms of action of anti‐CD38 monoclonal antibodies (mAbs), such as daratumumab (DARA), is required to identify patients…”
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The Proteasome Inhibitor Bortezomib Maintains Osteocyte Viability in Multiple Myeloma Patients by Reducing Both Apoptosis and Autophagy: A New Function for Proteasome Inhibitors by Toscani, Denise, Palumbo, Carla, Dalla Palma, Benedetta, Ferretti, Marzia, Bolzoni, Marina, Marchica, Valentina, Sena, Paola, Martella, Eugenia, Mancini, Cristina, Ferri, Valentina, Costa, Federica, Accardi, Fabrizio, Craviotto, Luisa, Aversa, Franco, Giuliani, Nicola

“…ABSTRACT Multiple myeloma (MM) is characterized by severely imbalanced bone remodeling. In this study, we investigated the potential effect of proteasome…”
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Identification of PSMB4 and PSMD4 as novel target genes correlated with 1q21 amplification in patients with smoldering myeloma and multiple myeloma by Garcia, Jessica Burroughs, Storti, Paola, Iannozzi, Nicolas Thomas, Marchica, Valentina, Agnelli, Luca, Toscani, Denise, Franceschi, Valentina, Todaro, Giannalisa, Sammarelli, Gabriella, Notarfranchi, Laura, Scita, Matteo, Palma, Benedetta Dalla, Raimondi, Vincenzo, Lungu, Oxana, Pruneri, Giancarlo, Donofrio, Gaetano, Giuliani, Nicola

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Phase II Trial of Maintenance Treatment With IL2 and Zoledronate in Multiple Myeloma After Bone Marrow Transplantation: Biological and Clinical Results by Fazzi, Rita, Petrini, Iacopo, Giuliani, Nicola, Morganti, Riccardo, Carulli, Giovanni, Dalla Palma, Benedetta, Notarfranchi, Laura, Galimberti, Sara, Buda, Gabriele

“…Maintenance treatment after autologous bone marrow transplantation in multiple myeloma improves the outcome of patients. We designed a phase II clinical trial…”
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Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability by Chiu, Martina, Toscani, Denise, Marchica, Valentina, Taurino, Giuseppe, Costa, Federica, Bianchi, Massimiliano G., Andreoli, Roberta, Franceschi, Valentina, Storti, Paola, Burroughs-Garcia, Jessica, Eufemiese, Rosa Alba, Dalla Palma, Benedetta, Campanini, Nicoletta, Martella, Eugenia, Mancini, Cristina, Shan, Jixiu, Kilberg, Michael S., D’Amico, Giovanna, Dander, Erica, Agnelli, Luca, Pruneri, Giancarlo, Donofrio, Gaetano, Bussolati, Ovidio, Giuliani, Nicola

“…Multiple myeloma (MM) cells consume huge amounts of glutamine and, as a consequence, the amino acid concentration is lower-than-normal in the bone marrow (BM)…”
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Immune response to SARS-CoV-2 mRNA vaccination and booster dose in patients with multiple myeloma and monoclonal gammopathies: impact of Omicron variant on the humoral response by Storti, Paola, Marchica, Valentina, Vescovini, Rosanna, Franceschi, Valentina, Russo, Luca, Notarfranchi, Laura, Raimondi, Vincenzo, Toscani, Denise, Burroughs Garcia, Jessica, Costa, Federica, Dalla Palma, Benedetta, Iannozzi, Nicolas Thomas, Sammarelli, Gabriella, Donofrio, Gaetano, Giuliani, Nicola

“…The humoral and cellular response to SARS-CoV-2 mRNA full vaccination and booster dose as well as the impact of the spike variants, including Omicron, are…”
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PD-L1/PD-1 Pattern of Expression Within the Bone Marrow Immune Microenvironment in Smoldering Myeloma and Active Multiple Myeloma Patients by Costa, Federica, Vescovini, Rosanna, Marchica, Valentina, Storti, Paola, Notarfranchi, Laura, Dalla Palma, Benedetta, Toscani, Denise, Burroughs-Garcia, Jessica, Catarozzo, Maria Teresa, Sammarelli, Gabriella, Giuliani, Nicola

“…The PD-1/PD-L1 axis has recently emerged as an immune checkpoint that controls antitumor immune responses also in hematological malignancies. However, the use…”
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Bone marrow Dikkopf‐1 levels are a new independent risk factor for progression in patients with smouldering myeloma by Dalla Palma, Benedetta, Marchica, Valentina, Pedrazzoni, Mario, Accardi, Fabrizio, Notarfranchi, Laura, Goldoni, Matteo, De Luca, Federica, Costa, Federica, Storti, Paola, Toscani, Denise, Sammarelli, Gabriella, Bonomini, Sabrina, Aversa, Franco, Giuliani, Nicola

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