Biomimetic Platelet‐Cloaked Nanoparticles for the Delivery of Anti‐Inflammatory Curcumin in the Treatment of Atherosclerosis

Atherosclerosis still represents a major driver of cardiovascular diseases worldwide. Together with accumulation of lipids in the plaque, inflammation is recognized as one of the key players in the formation and development of atherosclerotic plaque. Systemic anti‐inflammatory treatments are success...

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Published in:	Advanced healthcare materials Vol. 13; no. 15; pp. e2302074 - n/a
Main Authors:	Fontana, Flavia, Molinaro, Giuseppina, Moroni, Sofia, Pallozzi, Giulia, Ferreira, Mónica P. A., Tello, Rubén Pareja, Elbadri, Khalil, Torrieri, Giulia, Correia, Alexandra, Kemell, Marianna, Casettari, Luca, Celia, Christian, Santos, Hélder A.
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 01-06-2024 John Wiley and Sons Inc
Subjects:	Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology anti‐inflammatory Arteriosclerosis Atherosclerosis Atherosclerosis - drug therapy biohybrid Biomimetic Materials - chemistry Biomimetic Materials - pharmacology Blood Platelets - drug effects Blood Platelets - metabolism Cardiovascular diseases Cell membranes Curcumin Curcumin - chemistry Curcumin - pharmacology Effectiveness Endothelial cells Enzyme-linked immunosorbent assay Health services Human Umbilical Vein Endothelial Cells Humans Immune response Immune system Inflammation Lipids Lipopolysaccharides Macrophages Macrophages - drug effects Macrophages - metabolism Mice Nanoparticles Nanoparticles - chemistry Platelets platelets membrane Polymerase chain reaction RAW 264.7 Cells Side effects Smooth muscle Tannic acid Tannins - chemistry Tannins - pharmacology atherosclerosis anti‐inflammatory nanoparticles biohybrid platelets membrane
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Summary:	Atherosclerosis still represents a major driver of cardiovascular diseases worldwide. Together with accumulation of lipids in the plaque, inflammation is recognized as one of the key players in the formation and development of atherosclerotic plaque. Systemic anti‐inflammatory treatments are successful in reducing the disease burden, but are correlated with severe side effects, underlining the need for targeted formulations. In this work, curcumin is chosen as the anti‐inflammatory payload model and further loaded in lignin‐based nanoparticles (NPs). The NPs are then coated with a tannic acid (TA)− Fe (III) complex and further cloaked with fragments derived from platelet cell membrane, yielding NPs with homogenous size. The two coatings increase the interaction between the NPs and cells, both endothelial and macrophages, in steady state or inflamed status. Furthermore, NPs are cytocompatible toward endothelial, smooth muscle and immune cells, while not inducing immune activation. The anti‐inflammatory efficacy is demonstrated in endothelial cells by real‐time quantitative polymerase chain reaction and ELISA assay where curcumin‐loaded NPs decrease the expression of Nf‐κb, TGF‐β1, IL‐6, and IL‐1β in lipopolysaccharide‐inflamed cells. Overall, due to the increase in the cell−NP interactions and the anti‐inflammatory efficacy, these NPs represent potential candidates for the targeted anti‐inflammatory treatment of atherosclerosis. Biohybrid nanoparticles (NPs) are developed for the delivery of anti‐inflammatory curcumin in atherosclerosis. Lignin NPs are coated with a tannic acid (TA)‐iron (III) complex and cloaked with fragments of platelet membranes. The particles are cytocompatible and decrease the expression of pro‐inflammatory genes in LPS‐induced inflamed endothelial cells, while the cloaking increases the interaction with the target cells.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2192-2640 2192-2659 2192-2659
DOI:	10.1002/adhm.202302074