Search Results - "Pallis, M"

Analysis of factors that affect in vitro chemosensitivity of leukaemic stem and progenitor cells to gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukaemia by Jawad, M, Seedhouse, C, Mony, U, Grundy, M, Russell, N H, Pallis, M

“…Relapse in acute myeloid leukaemia (AML) is considered to result from the persistence of drug-resistant leukaemic stem and progenitor cells (LSPC) within a…”
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Resistance to FLT3 inhibition in an in vitro model of primary AML cells with a stem cell phenotype in a defined microenvironment by Mony, U, Jawad, M, Seedhouse, C, Russell, N, Pallis, M

“…Relapse in acute myeloid leukaemia (AML) is mediated by survival of leukaemic stem cells following remission-induction chemotherapy. It would therefore be…”
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DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412 by SEEDHOUSE, C. H, HUNTER, H. M, LLOYD-LEWIS, B, MASSIP, A-M, PALLIS, M, CARTER, Gl, GRUNDY, M, SHANG, S, RUSSELL, N. H

“…The presence of internal tandem duplications (ITD) mutations in the FMS-like tyrosine kinase 3 (FLT3) receptor influences the risk of relapse in acute myeloid…”
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Strategies for overcoming p-glycoprotein-mediated drug resistance in acute myeloblastic leukaemia by PALLIS, M, RUSSELL, N

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Interleukin-1β maintains an apoptosis-resistant phenotype in the blast cells of acute myeloid leukaemia via multiple pathways by TURZANSKI, J, GRUNDY, M, RUSSELL, N. H, PALLIS, M

“…Blast cell survival in suspension culture is associated with chemoresistance in acute myeloid leukaemia (AML). Autonomous production of IL-1β by AML blasts is…”
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Analysis of the interaction of induction regimens with p-glycoprotein expression in patients with acute myeloid leukaemia: results from the MRC AML15 trial by Pallis, M, Hills, R, White, P, Grundy, M, Russell, N, Burnett, A

“…Retrospective analyses in non-randomised cohorts suggest that regimens containing fludarabine/Ara C and/or idarubicin/ara C may be more effective than…”
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Resistance to spontaneous apoptosis in acute myeloid leukaemia blasts is associated with p‐glycoprotein expression and function, but not with the presence of FLT3 internal tandem duplications by Pallis, Monica, Turzanski, Julie, Grundy, Martin, Seedhouse, Claire, Russell, Nigel

“…The ability of acute myeloid leukaemia (AML) blasts to survive in culture has been associated with poor patient response to chemotherapy. Other biological…”
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Chronic rupture of a patellar tendon: a technique for reconstruction with Achilles allograft by Falconiero, R P, Pallis, M P

“…Chronic ruptures of the patellar tendon fortunately are an uncommon event. These ruptures are often difficult to repair because they are generally accompanied…”
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P-glycoprotein expression is associated with resistance to spontaneous in vitro apoptosis in AML by Pallis, M, Russell, N

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Ultrasound assessment of bladder volume: Is it valid after delivery? by Pallis, Lucinda M., Wilson, Melissa

“…Aim:  To assess the validity of a commercially available bladder volume scanner in the puerperium. Methods:  A prospective blinded comparison of bladder volume…”
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Early allogeneic transplantation for refractory or relapsed acute leukaemia following remission induction with FLAG by BYRNE, J. L, DASGUPTA, E, PALLIS, M, TURZANSKI, J, FORMAN, K, MITCHELL, D, HAYNES, A, RUSSELL, N

“…The prognosis for patients with secondary AML, primary resistant AML or ALL and early (<12 months) relapse of acute leukaemia remains extremely poor with…”
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Contrasting in vitro effects for the combination of fludarabine, cytosine arabinoside (Ara-C) and granulocyte colony-stimulating factor (FLAG) compared with daunorubicin and Ara-C in P-glycoprotein-positive and p-glycoprotein-negative acute myeloblastic leukaemia by HIGASHI, Y, TURZANSKI, J, PALLIS, M, RUSSELL, N. H

“…It has been suggested that the FLAG remission induction regimen comprising fludarabine (F-ara), cytosine arabinoside (Ara-C) and granulocyte colony-stimulating…”
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Use of standardized flow cytometric determinants of multidrug resistance to analyse response to remission induction chemotherapy in patients with acute myeloblastic leukaemia by Pallis, M., Turzanski, J., Harrison, G., Wheatley, K., Langabeer, S., Burnett, A. K., Russell, N. H.

“…We have used a combination of flow cytometric assays to define multidrug resistance (MDR) positive and negative blasts in cryopreserved samples from 47 MRC…”
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Comments on: Multidrug resistance-associated protein (MRP) expression is correlated with expression of aberrant p53 protein in colorectal cancer, Fukushima Y, Oshika Y, Tokunaga T, et al., Eur J Cancer 1999, 35, 935–938. Mutant p53 and high expression of MRP are associated in acute myeloblastic leukaemia by Turzanski, J., Zhu, Y.-M., Pallis, M.J., Russell, N.H.

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Strategy for Naturelike Designer Transcription Factors with Reduced Toxicity by Bach, Christian, Patra, Prabir K., Pallis, Jani M., Sherman, William B., Bajwa, Hassan

“…For clinical applications, the biological functions of DNA-binding proteins require that they interact with their target binding site with high affinity and…”
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Functional multidrug resistance in acute myeloblastic leukaemia : a standardized flow cytometric assay for intracellular daunorubicin accumulation by PALLIS, M, RUSSELL, N. H

“…We have developed a standardized flow cytometric method for the measurement of in vitro multidrug resistance in acute myeloblastic leukaemia (AML) blasts,…”
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Blast maturity and CD34 expression determine the effects of the differentiating agents KH1060 and 9-cis-retinoic acid on the differentiation and clonogenicity of non-M3 acute myeloid leukaemia cells by PALLIS, M, TURZANSKI, J, RUSSELL, N. H

“…The vitamin D analogue KH1060 and the retinoids all-trans retinoic acid (ATRA), 9-cis-retinoic acid (9-cRA) and 4-hydroxyphenyl retinamide (4-HPR) induce…”
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Reproducible flow cytometric methodology for measuring multidrug resistance in leukaemic blasts by Pallis, M, Turzanski, J, Langabeer, S, Russell, N H

“…In order to bring MDR analysis into a clinical setting, reproducible assays with clear cut off points to define MDR positivity must be used. Sensitivity can…”
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P-glycoprotein plays a drug-efflux–independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway by Pallis, Monica, Russell, Nigel

“…P-glycoprotein (pgp), which is the product of the MDR1(multidrug resistance-1) gene, has an established role as a mediator of cytotoxic drug resistance in…”
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Nailfold capillary density as a possible indicator of pulmonary capillary loss in systemic lupus erythematosus but not in mixed connective tissue disease by Pallis, M, Hopkinson, N, Powell, R

“…Nailfold capillary density was measured in 24 patients with systemic lupus erythematosus (SLE), 14 with mixed connective tissue disease (MCTD) and 21 healthy…”
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