Search Results - "Pallini, Roberto"

Hypoxia, Inflammation and Necrosis as Determinants of Glioblastoma Cancer Stem Cells Progression by Papale, Marco, Buccarelli, Mariachiara, Mollinari, Cristiana, Russo, Matteo A, Pallini, Roberto, Ricci-Vitiani, Lucia, Tafani, Marco

“…Tumor hypoxic microenvironment causes hypoxia inducible factor 1 alpha (HIF-1α) activation and necrosis with alarmins release. Importantly, HIF-1α also…”
Get full text

Rapid and Efficient Invasion Assay of Glioblastoma in Human Brain Organoids by Goranci-Buzhala, Gladiola, Mariappan, Aruljothi, Gabriel, Elke, Ramani, Anand, Ricci-Vitiani, Lucia, Buccarelli, Mariachiara, D’Alessandris, Quintino Giorgio, Pallini, Roberto, Gopalakrishnan, Jay

“…Glioblastoma (GBM) possesses glioma stem cells (GSCs) that exhibit aggressive invasion behavior in the brain. Current preclinical GBM invasion assays using…”
Get full text

Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma by Haas, Tobias L., Sciuto, Maria Rita, Brunetto, Lidia, Valvo, Cecilia, Signore, Michele, Fiori, Micol E., di Martino, Simona, Giannetti, Stefano, Morgante, Liliana, Boe, Alessandra, Patrizii, Michele, Warnken, Uwe, Schnölzer, Martina, Ciolfi, Andrea, Di Stefano, Chiara, Biffoni, Mauro, Ricci-Vitiani, Lucia, Pallini, Roberto, De Maria, Ruggero

“…Functionally relevant markers of glioblastoma stem-like cells (GSCs) have potential for therapeutic targeting to treat this aggressive disease. Here we used…”
Get full text

Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth by Buccarelli, Mariachiara, D'Alessandris, Quintino Giorgio, Matarrese, Paola, Mollinari, Cristiana, Signore, Michele, Cappannini, Andrea, Martini, Maurizio, D'Aliberti, Pierluigi, De Luca, Gabriele, Pedini, Francesca, Boe, Alessandra, Biffoni, Mauro, Pallini, Roberto, Ricci-Vitiani, Lucia

“…Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults, characterized by a poor prognosis mainly due to recurrence and…”
Get full text

Chlorpromazine induces cytotoxic autophagy in glioblastoma cells via endoplasmic reticulum stress and unfolded protein response by Matteoni, Silvia, Matarrese, Paola, Ascione, Barbara, Ricci-Vitiani, Lucia, Pallini, Roberto, Villani, Veronica, Pace, Andrea, Paggi, Marco G, Abbruzzese, Claudia

“…Glioblastoma (GBM; grade IV glioma) is characterized by a very short overall survival time and extremely low 5-year survival rates. We intend to promote…”
Get full text

Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme by Pallini, Roberto, Ricci-Vitiani, Lucia, Banna, Giuseppe Luigi, Signore, Michele, Lombardi, Dario, Todaro, Matilde, Stassi, Giorgio, Martini, Maurizio, Maira, Giulio, Larocca, Luigi Maria, De Maria, Ruggero

“…Purpose: Cancer stem cells (CSC) are thought to represent the population of tumorigenic cells responsible for tumor development. The stem cell antigen CD133…”
Get full text

Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation by Mongiardi, Maria Patrizia, Radice, Giulia, Piras, Maurizia, Stagni, Venturina, Pacioni, Simone, Re, Agnese, Putti, Sabrina, Ferrè, Fabrizio, Farsetti, Antonella, Pallini, Roberto, Barilà, Daniela, Levi, Andrea, Falchetti, Maria Laura

“…Inhibitors of Vascular Endothelial Growth Factor target both tumor vasculature and cancer cells that have hijacked VEGF Receptors (VEGFRs) signaling for tumor…”
Get full text

TRPML2 Mucolipin Channels Drive the Response of Glioma Stem Cells to Temozolomide and Affect the Overall Survival in Glioblastoma Patients by Morelli, Maria Beatrice, Nabissi, Massimo, Amantini, Consuelo, Maggi, Federica, Ricci-Vitiani, Lucia, Pallini, Roberto, Santoni, Giorgio

“…The survival of patients with glioblastoma (GBM) is poor. The main cause is the presence of glioma stem cells (GSCs), exceptionally resistant to temozolomide…”
Get full text

Mir-370-3p Impairs Glioblastoma Stem-Like Cell Malignancy Regulating a Complex Interplay between HMGA2/HIF1A and the Oncogenic Long Non-Coding RNA (lncRNA) NEAT1 by Lulli, Valentina, Buccarelli, Mariachiara, Ilari, Ramona, Castellani, Giorgia, De Dominicis, Chiara, Di Giamberardino, Alessandra, D Alessandris, Quintino Giorgio, Giannetti, Stefano, Martini, Maurizio, Stumpo, Vittorio, Boe, Alessandra, De Luca, Gabriele, Biffoni, Mauro, Marziali, Giovanna, Pallini, Roberto, Ricci-Vitiani, Lucia

“…Glioblastoma (GBM) is the most aggressive and prevalent form of a human brain tumor in adults. Several data have demonstrated the implication of microRNAs…”
Get full text

The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response by D'Alessandris, Quintino Giorgio, Biffoni, Mauro, Martini, Maurizio, Runci, Daniele, Buccarelli, Mariachiara, Cenci, Tonia, Signore, Michele, Stancato, Louis, Olivi, Alessandro, De Maria, Ruggero, Larocca, Luigi M, Ricci-Vitiani, Lucia, Pallini, Roberto

“…Advances from glioma stemlike cell (GSC) research, though increasing our knowledge of glioblastoma (GBM) biology, do not influence clinical decisions yet. We…”
Get full text

Endothelial Cells Lining Sporadic Cerebral Cavernous Malformation Cavernomas Undergo Endothelial-to-Mesenchymal Transition by Bravi, Luca, Malinverno, Matteo, Pisati, Federica, Rudini, Noemi, Cuttano, Roberto, Pallini, Roberto, Martini, Maurizio, Larocca, Luigi Maria, Locatelli, Marco, Levi, Vincenzo, Bertani, Giulio Andrea, Dejana, Elisabetta, Lampugnani, Maria Grazia

“…Cerebral cavernous malformation (CCM) is characterized by multiple lumen vascular malformations in the central nervous system that can cause neurological…”
Get full text

Pervasive structural heterogeneity rewires glioblastoma chromosomes to sustain patient-specific transcriptional programs by Xie, Ting, Danieli-Mackay, Adi, Buccarelli, Mariachiara, Barbieri, Mariano, Papadionysiou, Ioanna, D’Alessandris, Q. Giorgio, Robens, Claudia, Übelmesser, Nadine, Vinchure, Omkar Suhas, Lauretti, Liverana, Fotia, Giorgio, Schwarz, Roland F., Wang, Xiaotao, Ricci-Vitiani, Lucia, Gopalakrishnan, Jay, Pallini, Roberto, Papantonis, Argyris

“…Glioblastoma multiforme (GBM) encompasses brain malignancies marked by phenotypic and transcriptional heterogeneity thought to render these tumors aggressive,…”
Get full text

Mesenchymal stromal cells primed with paclitaxel provide a new approach for cancer therapy by Pessina, Augusto, Bonomi, Arianna, Coccè, Valentina, Invernici, Gloria, Navone, Stefania, Cavicchini, Loredana, Sisto, Francesca, Ferrari, Maura, Viganò, Lucia, Locatelli, Alberta, Ciusani, Emilio, Cappelletti, Graziella, Cartelli, Daniele, Arnaldo, Caruso, Parati, Eugenio, Marfia, Giovanni, Pallini, Roberto, Falchetti, Maria Laura, Alessandri, Giulio

“…Mesenchymal stromal cells may represent an ideal candidate to deliver anti-cancer drugs. In a previous study, we demonstrated that exposure of mouse bone…”
Get full text

Dissecting Stemness in Aggressive Intracranial Meningiomas: Prognostic Role of SOX2 Expression by Di Bonaventura, Rina, Martini, Maurizio, Cenci, Tonia, Caccavella, Valerio Maria, Barresi, Valeria, Gessi, Marco, Albanese, Alessio, Lauretti, Liverana, Pallini, Roberto, D'Alessandris, Quintino Giorgio, Olivi, Alessandro

“…Meningiomas are mostly benign tumors that, at times, can behave aggressively, displaying recurrence despite gross-total resection (GTR) and progression to…”
Get full text

Neuromodulation for Brain Tumors: Myth or Reality? A Narrative Review by D'Alessandris, Quintino Giorgio, Menna, Grazia, Izzo, Alessandro, D'Ercole, Manuela, Della Pepa, Giuseppe Maria, Lauretti, Liverana, Pallini, Roberto, Olivi, Alessandro, Montano, Nicola

“…In recent years, research on brain cancers has turned towards the study of the interplay between the tumor and its host, the normal brain. Starting from the…”
Get full text

Effectiveness of Flattening-Filter-Free versus Flattened Beams in V79 and Glioblastoma Patient-Derived Stem-like Cells by Dini, Valentina, Esposito, Giuseppe, Sacconi, Andrea, D'Andrea, Marco, Tabocchini, Maria Antonella, Anello, Pasquale, Ricci-Vitiani, Lucia, Buccarelli, Mariachiara, Pallini, Roberto, Strigari, Lidia

“…Literature data on the administration of conventional high-dose beams with (FF) or without flattening filters (FFF) show conflicting results on biological…”
Get full text

FMRP modulates the Wnt signalling pathway in glioblastoma by Pedini, Giorgia, Buccarelli, Mariachiara, Bianchi, Fabrizio, Pacini, Laura, Cencelli, Giulia, D’Alessandris, Quintino Giorgio, Martini, Maurizio, Giannetti, Stefano, Sasso, Franceschina, Melocchi, Valentina, Farace, Maria Giulia, Achsel, Tilmann, Larocca, Luigi M., Ricci-Vitiani, Lucia, Pallini, Roberto, Bagni, Claudia

“…Converging evidence indicates that the Fragile X Messenger Ribonucleoprotein (FMRP), which absent or mutated in Fragile X Syndrome (FXS), plays a role in many…”
Get full text

Olfactory Groove Meningioma: Report of 99 Cases Surgically Treated at the Catholic University School of Medicine, Rome by Pallini, Roberto, Fernandez, Eduardo, Lauretti, Liverana, Doglietto, Francesco, D’Alessandris, Quintino Giorgio, Montano, Nicola, Capo, Gabriele, Meglio, Mario, Maira, Giulio

“…Objective We reviewed our series of olfactory groove meningiomas (OGMs) with the aim to relate the surgical approach with outcome and to define clinical and…”
Get full text

Clinical and NGS predictors of response to regorafenib in recurrent glioblastoma by Chiesa, Silvia, Mangraviti, Antonella, Martini, Maurizio, Cenci, Tonia, Mazzarella, Ciro, Gaudino, Simona, Bracci, Serena, Martino, Antonella, Della Pepa, Giuseppe M., Offi, Martina, Gessi, Marco, Russo, Rosellina, Martucci, Matia, Beghella Bartoli, Francesco, Larocca, Luigi M., Lauretti, Liverana, Olivi, Alessandro, Pallini, Roberto, Balducci, Mario, D’Alessandris, Quintino Giorgio

“…Predictive factors for response to regorafenib in recurrent glioblastoma, IDH- wildtype, are scarcely recognized. The objective of this study was to identify…”
Get full text

Anticancer Properties of the Antipsychotic Drug Chlorpromazine and Its Synergism With Temozolomide in Restraining Human Glioblastoma Proliferation In Vitro by Matteoni, Silvia, Matarrese, Paola, Ascione, Barbara, Buccarelli, Mariachiara, Ricci-Vitiani, Lucia, Pallini, Roberto, Villani, Veronica, Pace, Andrea, Paggi, Marco G, Abbruzzese, Claudia

“…The extremely poor prognosis of patients affected by glioblastoma (GBM, grade IV glioma) prompts the search for new and more effective therapies. In this…”
Get full text