Search Results - "Palladino, N."

2-Chlorofatty acids: lipid mediators of neutrophil extracellular trap formation by Palladino, ElisaN.D., Katunga, Lalage A., Kolar, Grant R., Ford, David A.

“…Neutrophils form neutrophil extracellular traps (NETs), which have been implicated in microcirculatory plugging. NET formation (NETosis) involves the fusion of…”
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ABCG1 regulates pulmonary surfactant metabolism in mice and men[S] by de Aguiar Vallim, Thomas Q., Lee, Elinor, Merriott, David J., Goulbourne, Christopher N., Cheng, Joan, Cheng, Angela, Gonen, Ayelet, Allen, Ryan M., Palladino, Elisa N.D., Ford, David A., Wang, Tisha, Baldán, Ángel, Tarling, Elizabeth J.

“…Idiopathic pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by accumulation of surfactant. Surfactant synthesis and secretion are…”
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Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma by James, Briana N., Oyeniran, Clement, Sturgill, Jamie L., Newton, Jason, Martin, Rebecca K., Bieberich, Erhard, Weigel, Cynthia, Maczis, Melissa A., Palladino, Elisa N.D., Lownik, Joseph C., Trudeau, John B., Cook-Mills, Joan M., Wenzel, Sally, Milstien, Sheldon, Spiegel, Sarah

“…Nothing is known about the mechanisms by which increased ceramide levels in the lung contribute to allergic responses and asthma severity. We sought to…”
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Bromofatty aldehyde derived from bromine exposure and myeloperoxidase and eosinophil peroxidase modify GSH and protein by Duerr, Mark A., Palladino, Elisa N.D., Hartman, Celine L., Lambert, James A., Franke, Jacob D., Albert, Carolyn J., Matalon, Sadis, Patel, Rakesh P., Slungaard, Arne, Ford, David A.

“…α-Chlorofatty aldehydes (α-ClFALDs) and α-bromofatty aldehydes (α-BrFALDs) are produced in activated neutrophils and eosinophils. This study investigated the…”
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Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism by Palladino, ElisaN.D., Wang, Wen-yi, Albert, Carolyn J., Langhi, Cédric, Baldán, Ángel, Ford, David A.

“…α-Chlorofatty aldehydes are generated from myeloperoxidase-derived HOCl targeting plasmalogens, and are subsequently oxidized to α-chlorofatty acids (α-ClFAs)…”
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Platelet-Activating Factor Quantification Using Reversed Phase Liquid Chromatography and Selected Reaction Monitoring in Negative Ion Mode by Pike, Daniel P., Hartman, Celine L., Weissler, Gregory J., Palladino, Elisa N. D., Albert, Carolyn J., Ford, David A.

“…Platelet-activating factor (PAF) is a potent biologically active phospholipid that mediates human physiological and pathophysiologic responses. PAF levels…”
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Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis by Wang, Bo, Rong, Xin, Palladino, Elisa N.D., Wang, Jiafang, Fogelman, Alan M., Martín, Martín G., Alrefai, Waddah A., Ford, David A., Tontonoz, Peter

“…Adequate availability of cellular building blocks, including lipids, is a prerequisite for cellular proliferation, but excess dietary lipids are linked to…”
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Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer by Weigel, Cynthia, Maczis, Melissa A, Palladino, Elisa N D, Green, Christopher D, Maceyka, Michael, Guo, Chunqing, Wang, Xiang-Yang, Dozmorov, Mikhail G, Milstien, Sheldon, Spiegel, Sarah

“…Reciprocal interactions between breast cancer cells and the tumor microenvironment (TME) are important for cancer progression and metastasis. We report here…”
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Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice by James, Briana N., Weigel, Cynthia, Green, Christopher D., Brown, Ryan D. R., Palladino, Elisa N. D., Tharakan, Anuj, Milstien, Sheldon, Proia, Richard L., Martin, Rebecca K., Spiegel, Sarah

“…Genome‐wide association studies have linked the ORM (yeast)–like protein isoform 3 (ORMDL3) to asthma severity. Although ORMDL3 is a member of a family that…”
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Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking by Palladino, Elisa N D, Bernas, Tytus, Green, Christopher D, Weigel, Cynthia, Singh, Sandeep K, Senkal, Can E, Martello, Andrea, Kennelly, John P, Bieberich, Erhard, Tontonoz, Peter, Ford, David A, Milstien, Sheldon, Eden, Emily R, Spiegel, Sarah

“…Membrane contact sites (MCS), close membrane apposition between organelles, are platforms for interorganellar transfer of lipids including cholesterol,…”
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Targeting defective sphingosine kinase 1 in Niemann–Pick type C disease with an activator mitigates cholesterol accumulation by Newton, Jason, Palladino, Elisa N.D., Weigel, Cynthia, Maceyka, Michael, Gräler, Markus H., Senkal, Can E., Enriz, Ricardo D., Marvanova, Pavlina, Jampilek, Josef, Lima, Santiago, Milstien, Sheldon, Spiegel, Sarah

“…Niemann–Pick type C (NPC) disease is a lysosomal storage disorder arising from mutations in the cholesterol-trafficking protein NPC1 (95%) or NPC2 (5%). These…”
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The chlorinated lipidome originating from myeloperoxidase-derived HOCl targeting plasmalogens: Metabolism, clearance, and biological properties by Palladino, Elisa N.D., Hartman, Celine L., Albert, Carolyn J., Ford, David A.

“…Myeloperoxidase produces the two-electron oxidant HOCl, which targets plasmalogen phospholipids liberating 2-chlorofatty aldehyde. 2-Chlorofatty aldehyde has…”
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Transitory Severe CNS Adverse Effects after Accidental Efavirenz Overdose During Post-Exposure HIV Prophylaxis by Pasticci, M.B., Bonora, S., Di Candilo, F., Lapalorcia, L.M., Palladino, N., Baldelli, F.

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Clinical Efficacy and Tolerability of Caspofungin in a Renal Transplant Patient with Aspergillus flavus Lung Infection: Case Report by Pasticci, M.B., Barchiesi, F., Fallani, S., Palladino, N., Lapalorcia, L.M., Gubbiotti, M., Cozzari, M., Novelli, A., Baldelli, F.

“…Organ transplant recipients are at increased risk for severe invasive aspergillosis, and amphotericin deoxycholate has been the standard treatment for many…”
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Prosthetic infections following total knee arthroplasty: a six-year prospective study (1997–2002) by Pasticci, M. B., Mancini, G., Lapalorcia, L. M., Morosi, S., Palladino, N., Zucchini, M., Baldelli, F.

“…This paper reports on a prospective observational study that evaluated the frequency of prosthetic infections after total knee arthroplasty. During a six-year…”
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733 Management of children with cystic fibrosis–positive neonatal screening/CFTR-related metabolic syndrome: a national real world survey by Terlizzi, V., Claut, L., Tosco, A., Fevola, C., Ambroni, M., Calderazzo, M., Esposito, I., Fabrizzi, B., Leonetti, G., Lombardo, M., Maschio, M., Palladino, N., Pauro, F., Pisi, G., Poli, P., Ripani, P., Ros, M., Rotolo, N., Salvatore, D., Termini, L., Troiani, P., Vitullo, P., Zanda, M., Castellani, C.

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P109 Safety of elexacaftor/tezacaftor/ivacaftor in patients 6 through 18 years with cystic fibrosis and at least one F508del allele: a retrospective Italian multicenter study by Terlizzi, V., Fevola, C., Presti, S., Castaldo, A., Daccò, V., Claut, L., Sepe, A., Majo, F., Casciaro, R., Esposito, I., Vitullo, P., Salvi, M., Troiani, P., Ficili, F., Parisi, G.F., Pantano, S., Costa, S., Leonetti, G., Palladino, N., Taccetti, G., Bonomi, P., Salvatore, D.

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Chlorinated Lipids Activate Human Neutrophils by Palladino, Elisa N. D., Ford, David A

“…Abstract only Neutrophil activation is orchestrated by a complex array of mechanisms including phosphorylation and activation of NADPH oxidase and subsequent…”
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Myeloperoxidase‐Derived 2‐Chlorofatty Acids Make Neutrophils Go NETs by Palladino, Elisa N. D., Katunga, Lalage A., Ford, David A.

“…Neutrophils represent the major effector cells of innate immunity. One mechanism for neutrophil‐mediated microbe killing is through the release of neutrophil…”
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ER phospholipid composition modulates lipogenesis during feeding and in obesity by Rong, Xin, Wang, Bo, Palladino, Elisa Nd, de Aguiar Vallim, Thomas Q, Ford, David A, Tontonoz, Peter

“…Sterol regulatory element-binding protein 1c (SREBP-1c) is a central regulator of lipogenesis whose activity is controlled by proteolytic cleavage. The…”
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