Search Results - "Palladino, Elisa N D"

ABCG1 regulates pulmonary surfactant metabolism in mice and men[S] by de Aguiar Vallim, Thomas Q., Lee, Elinor, Merriott, David J., Goulbourne, Christopher N., Cheng, Joan, Cheng, Angela, Gonen, Ayelet, Allen, Ryan M., Palladino, Elisa N.D., Ford, David A., Wang, Tisha, Baldán, Ángel, Tarling, Elizabeth J.

“…Idiopathic pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by accumulation of surfactant. Surfactant synthesis and secretion are…”
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Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism by Palladino, ElisaN.D., Wang, Wen-yi, Albert, Carolyn J., Langhi, Cédric, Baldán, Ángel, Ford, David A.

“…α-Chlorofatty aldehydes are generated from myeloperoxidase-derived HOCl targeting plasmalogens, and are subsequently oxidized to α-chlorofatty acids (α-ClFAs)…”
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2-Chlorofatty acids: lipid mediators of neutrophil extracellular trap formation by Palladino, ElisaN.D., Katunga, Lalage A., Kolar, Grant R., Ford, David A.

“…Neutrophils form neutrophil extracellular traps (NETs), which have been implicated in microcirculatory plugging. NET formation (NETosis) involves the fusion of…”
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Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma by James, Briana N., Oyeniran, Clement, Sturgill, Jamie L., Newton, Jason, Martin, Rebecca K., Bieberich, Erhard, Weigel, Cynthia, Maczis, Melissa A., Palladino, Elisa N.D., Lownik, Joseph C., Trudeau, John B., Cook-Mills, Joan M., Wenzel, Sally, Milstien, Sheldon, Spiegel, Sarah

“…Nothing is known about the mechanisms by which increased ceramide levels in the lung contribute to allergic responses and asthma severity. We sought to…”
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Bromofatty aldehyde derived from bromine exposure and myeloperoxidase and eosinophil peroxidase modify GSH and protein by Duerr, Mark A., Palladino, Elisa N.D., Hartman, Celine L., Lambert, James A., Franke, Jacob D., Albert, Carolyn J., Matalon, Sadis, Patel, Rakesh P., Slungaard, Arne, Ford, David A.

“…α-Chlorofatty aldehydes (α-ClFALDs) and α-bromofatty aldehydes (α-BrFALDs) are produced in activated neutrophils and eosinophils. This study investigated the…”
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Platelet-Activating Factor Quantification Using Reversed Phase Liquid Chromatography and Selected Reaction Monitoring in Negative Ion Mode by Pike, Daniel P., Hartman, Celine L., Weissler, Gregory J., Palladino, Elisa N. D., Albert, Carolyn J., Ford, David A.

“…Platelet-activating factor (PAF) is a potent biologically active phospholipid that mediates human physiological and pathophysiologic responses. PAF levels…”
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Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis by Wang, Bo, Rong, Xin, Palladino, Elisa N.D., Wang, Jiafang, Fogelman, Alan M., Martín, Martín G., Alrefai, Waddah A., Ford, David A., Tontonoz, Peter

“…Adequate availability of cellular building blocks, including lipids, is a prerequisite for cellular proliferation, but excess dietary lipids are linked to…”
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Sphingosine Kinase 2 in Stromal Fibroblasts Creates a Hospitable Tumor Microenvironment in Breast Cancer by Weigel, Cynthia, Maczis, Melissa A, Palladino, Elisa N D, Green, Christopher D, Maceyka, Michael, Guo, Chunqing, Wang, Xiang-Yang, Dozmorov, Mikhail G, Milstien, Sheldon, Spiegel, Sarah

“…Reciprocal interactions between breast cancer cells and the tumor microenvironment (TME) are important for cancer progression and metastasis. We report here…”
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Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice by James, Briana N., Weigel, Cynthia, Green, Christopher D., Brown, Ryan D. R., Palladino, Elisa N. D., Tharakan, Anuj, Milstien, Sheldon, Proia, Richard L., Martin, Rebecca K., Spiegel, Sarah

“…Genome‐wide association studies have linked the ORM (yeast)–like protein isoform 3 (ORMDL3) to asthma severity. Although ORMDL3 is a member of a family that…”
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Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking by Palladino, Elisa N D, Bernas, Tytus, Green, Christopher D, Weigel, Cynthia, Singh, Sandeep K, Senkal, Can E, Martello, Andrea, Kennelly, John P, Bieberich, Erhard, Tontonoz, Peter, Ford, David A, Milstien, Sheldon, Eden, Emily R, Spiegel, Sarah

“…Membrane contact sites (MCS), close membrane apposition between organelles, are platforms for interorganellar transfer of lipids including cholesterol,…”
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Targeting defective sphingosine kinase 1 in Niemann–Pick type C disease with an activator mitigates cholesterol accumulation by Newton, Jason, Palladino, Elisa N.D., Weigel, Cynthia, Maceyka, Michael, Gräler, Markus H., Senkal, Can E., Enriz, Ricardo D., Marvanova, Pavlina, Jampilek, Josef, Lima, Santiago, Milstien, Sheldon, Spiegel, Sarah

“…Niemann–Pick type C (NPC) disease is a lysosomal storage disorder arising from mutations in the cholesterol-trafficking protein NPC1 (95%) or NPC2 (5%). These…”
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The chlorinated lipidome originating from myeloperoxidase-derived HOCl targeting plasmalogens: Metabolism, clearance, and biological properties by Palladino, Elisa N.D., Hartman, Celine L., Albert, Carolyn J., Ford, David A.

“…Myeloperoxidase produces the two-electron oxidant HOCl, which targets plasmalogen phospholipids liberating 2-chlorofatty aldehyde. 2-Chlorofatty aldehyde has…”
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Chlorinated Lipids Activate Human Neutrophils by Palladino, Elisa N. D., Ford, David A

“…Abstract only Neutrophil activation is orchestrated by a complex array of mechanisms including phosphorylation and activation of NADPH oxidase and subsequent…”
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Myeloperoxidase‐Derived 2‐Chlorofatty Acids Make Neutrophils Go NETs by Palladino, Elisa N. D., Katunga, Lalage A., Ford, David A.

“…Neutrophils represent the major effector cells of innate immunity. One mechanism for neutrophil‐mediated microbe killing is through the release of neutrophil…”
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ER phospholipid composition modulates lipogenesis during feeding and in obesity by Rong, Xin, Wang, Bo, Palladino, Elisa Nd, de Aguiar Vallim, Thomas Q, Ford, David A, Tontonoz, Peter

“…Sterol regulatory element-binding protein 1c (SREBP-1c) is a central regulator of lipogenesis whose activity is controlled by proteolytic cleavage. The…”
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2-Chlorofatty Acids Function as New Lipid Mediators in Neutrophil Extracellular Trap Formation and Accelerate Their Own Clearance by Inducing PPAR-α Activity by Palladino, Elisa N. D

“…Neutrophils represent the first line of defense as they are the first to be recruited to the site of inflammation. Their role in inflammation is fundamental…”
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Targeting defective sphingosine kinase 1 in Niemann-Pick type C disease with an activator mitigates cholesterol accumulation by Newton, Jason, Palladino, Elisa N D, Weigel, Cynthia, Maceyka, Michael, Gräler, Markus H, Senkal, Can E, Enriz, Ricardo D, Marvanova, Pavlina, Jampilek, Josef, Lima, Santiago, Milstien, Sheldon, Spiegel, Sarah

“…Niemann-Pick type C (NPC) disease is a lysosomal storage disorder arising from mutations in the cholesterol-trafficking protein NPC1 (95%) or NPC2 (5%). These…”
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