Search Results - "Paliwal, Sunil"

Structural basis of CX-4945 binding to human protein kinase CK2 by Ferguson, Andrew D., Sheth, Payal R., Basso, Andrea D., Paliwal, Sunil, Gray, Kimberly, Fischmann, Thierry O., Le, Hung V.

“…Protein kinase CK2 (CK2), a constitutively active serine/threonine kinase, is involved in a variety of roles essential to the maintenance of cellular…”
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Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones:  Potent NK1 Antagonists by Reichard, Gregory A, Stengone, Carmine, Paliwal, Sunil, Mergelsberg, Ingrid, Majmundar, Sapna, Wang, Cheng, Tiberi, Robert, McPhail, Andrew T, Piwinski, John J, Shih, Neng-Yang

“…A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a “self-reproduction of the center of chirality” strategy is…”
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Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions by Shue, Ho-Jane, Chen, Xiao, Schwerdt, John H, Paliwal, Sunil, Blythin, David J, Lin, Ling, Gu, Danlin, Wang, Cheng, Reichard, Gregory A, Wang, Hongwu, Piwinski, John J, Duffy, Ruth A, Lachowicz, Jean E, Coffin, Vicki L, Nomeir, Amin A, Morgan, Cynthia A, Varty, Geoffrey B, Shih, Neng-Yang

“…A series of novel five-membered urea derivatives as potent NK1 receptor antagonists is described. The effects of substitution of a 4-fluoro group at the phenyl…”
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Design and biological characterization of a series of dual mechanism ERK1/2 inhibitors with a Triazolopyridinone core by Lotfaliansaremi, Sajedeh, Cornwell, Stephen, Casillas, Candice, Sabio, Michael, Tolias, Peter, Windsor, William, Paliwal, Sunil

“…Oncology clinical development programs have targeted the RAS/RAF/MEK/ERK signaling pathway with small molecule inhibitors for a variety of cancers during the…”
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Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer by Huang, Peter Q, Boren, Brant C, Hegde, Sayee G, Liu, Hui, Unni, Aditya K, Abraham, Sunny, Hopkins, Chad D, Paliwal, Sunil, Samatar, Ahmed A, Li, Jiali, Bunker, Kevin D

“…Wee1 inhibition has received great attention in the past decade as a promising therapy for cancer treatment. Therefore, a potent and selective Wee1 inhibitor…”
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Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors by Morris, Erick J, Jha, Sharda, Restaino, Clifford R, Dayananth, Priya, Zhu, Hugh, Cooper, Alan, Carr, Donna, Deng, Yongi, Jin, Weihong, Black, Stuart, Long, Brian, Liu, Jenny, Dinunzio, Edward, Windsor, William, Zhang, Rumin, Zhao, Shuxia, Angagaw, Minilik H, Pinheiro, Elaine M, Desai, Jagdish, Xiao, Li, Shipps, Gerald, Hruza, Alan, Wang, James, Kelly, Joe, Paliwal, Sunil, Gao, Xiaolei, Babu, Boga Sobhana, Zhu, Liang, Daublain, Pierre, Zhang, Ling, Lutterbach, Bart A, Pelletier, Marc R, Philippar, Ulrike, Siliphaivanh, Phieng, Witter, David, Kirschmeier, Paul, Bishop, W Robert, Hicklin, Daniel, Gilliland, D Gary, Jayaraman, Lata, Zawel, Leigh, Fawell, Stephen, Samatar, Ahmed A

“…The high frequency of activating RAS or BRAF mutations in cancer provides strong rationale for targeting the mitogen-activated protein kinase (MAPK) pathway…”
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Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology by Boga, Sobhana Babu, Alhassan, Abdul-Basit, Cooper, Alan B., Doll, Ronald, Shih, Neng-Yang, Shipps, Gerald, Deng, Yongqi, Zhu, Hugh, Nan, Yang, Sun, Robert, Zhu, Liang, Desai, Jagdish, Patel, Mehul, Muppalla, Kiran, Gao, Xiaolei, Wang, James, Yao, Xin, Kelly, Joseph, Gudipati, Subrahmanyam, Paliwal, Sunil, Tsui, Hon-Chung, Wang, Tong, Sherborne, Bradley, Xiao, Li, Hruza, Alan, Buevich, Alexei, Zhang, Li-Kang, Hesk, David, Samatar, Ahmed A., Carr, Donna, Long, Brian, Black, Stuart, Dayananth, Priya, Windsor, William, Kirschmeier, Paul, Bishop, Robert

“…[Display omitted] •Discovery of potent, selective and orally bioavailable ERK inhibitor for oncology.•Synthesis of tert 3-(S)thiomethyl pyrrolidine based ERK…”
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MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology by Boga, Sobhana Babu, Deng, Yongqi, Zhu, Liang, Nan, Yang, Cooper, Alan B., Shipps, Gerald W., Doll, Ronald, Shih, Neng-Yang, Zhu, Hugh, Sun, Robert, Wang, Tong, Paliwal, Sunil, Tsui, Hon-Chung, Gao, Xiaolei, Yao, Xin, Desai, Jagdish, Wang, James, Alhassan, Abdul Basit, Kelly, Joseph, Patel, Mehul, Muppalla, Kiran, Gudipati, Subrahmanyam, Zhang, Li-Kang, Buevich, Alexei, Hesk, David, Carr, Donna, Dayananth, Priya, Black, Stuart, Mei, Hong, Cox, Kathleen, Sherborne, Bradley, Hruza, Alan W., Xiao, Li, Jin, Weihong, Long, Brian, Liu, Gongjie, Taylor, Stacey A., Kirschmeier, Paul, Windsor, William T., Bishop, Robert, Samatar, Ahmed A.

“…The emergence and evolution of new immunological cancer therapies has sparked a rapidly growing interest in discovering novel pathways to treat cancer. Toward…”
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Thermally stimulated current and electrical conduction in metal (1)-ethyl cellulose-metal (1)/(2) systems by Khare, P K, Verma, Ashish, Paliwal, Sunil K

“…Depolarization current characteristics of solution grown pure ethyl cellulose (EC) films of about 20µm thickness have been studied as a function of electrode…”
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Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation by McElroy, William T., Tan, Zheng, Ho, Ginny, Paliwal, Sunil, Li, Guoqing, Seganish, W. Michael, Tulshian, Deen, Tata, James, Fischmann, Thierry O., Sondey, Christopher, Bian, Hong, Bober, Loretta, Jackson, James, Garlisi, Charles G., Devito, Kristine, Fossetta, James, Lundell, Daniel, Niu, Xiaoda

“…IRAK4 is a critical upstream kinase in the IL-1R/TLR signaling pathway. Inhibition of IRAK4 is hypothesized to be beneficial in the treatment of autoimmune…”
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Measurements of Molecular Electrostatic Field Effects in Edge-to-Face Aromatic Interactions and CH-π Interactions with Implications for Protein Folding and Molecular Recognition by Kim, Eun-il, Paliwal, Sunil, Wilcox, Craig S

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Structure-based drug design of clinical compound MK-8353, a novel inhibitor of ERK by Hruza, Alan, Boga, Sobhana Babu, Alhassan, Abdul-Basit, Cooper, Alan B., Doll, Ronald, Shih, Neng-Yang, Shipps, Gerald, Deng, Yongqi, Zhu, Hugh, Nan, Yang, Sun, Robert, Zhu, Liang, Desai, Jagdish, Patel, Mehul, Muppalla, Kiran, Gao, Xiaolei, Wang, James, Kelly, Joseph, Gudipati, Subrahmanyam, Paliwal, Sunil, Tsui, Hon-Chung, Wang, Tong, Sherborne, Bradley, Xiao, Li, Buevich, Alexei, Hesk, David, Samatar, Ahmed A., Carr, Donna, Long, Brian, Black, Stuart, Dayananth, Priya, Windsor, William, Kirschmeier, Paul, Bishop, Robert

“…Abstract only…”
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Discovery of a series of potent, orally active α,α-disubstituted piperidine NK1 antagonists by DONG XIAO, CHENG WANG, VARTY, Geoffrey, MORGAN, Cynthia, FEI LIU, NOMEIR, Amin, PALANI, Anandan, TSUI, Hon-Chung, REICHARD, Gregory, PALIWAL, Sunil, SHIH, Neng-Yang, ASLANIAN, Robert, DUFFY, Ruth, LACHOWICZ, Jean

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Discovery of a series of potent, orally active alpha , alpha -disubstituted piperidine NK sub(1 antagonists) by Xiao, Dong, Wang, Cheng, Palani, Anandan, Tsui, Hon-Chung, Reichard, Gregory, Paliwal, Sunil, Shih, Neng-Yang, Aslanian, Robert, Duffy, Ruth, Lachowicz, Jean, Varty, Geoffrey, Morgan, Cynthia, Liu, Fei, Nomeir, Amin

“…Modification of prototype NK sub(1 antagonist 2 resulted in the synthesis of a series of simple amides 6 and retroamides 9. These compounds were shown to be…”
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Cyclobutane derivatives as potent NK1 selective antagonists by WROBLESKI, Michelle Laci, REICHARD, Gregory A, PALIWAL, Sunil, SHAH, Sapna, TSUI, Hon-Chung, DUFFY, Ruth A, LACHOWICZ, Jean E, MORGAN, Cynthia A, VARTY, Geoffrey B, SHIH, Neng-Yang

“…A series of novel cyclobutane derivatives as potent and selective NK1 receptor antagonists is described. Several compounds in this series exhibited high in…”
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Discovery of a series of potent, orally active α,α-disubstituted piperidine NK 1 antagonists by Xiao, Dong, Wang, Cheng, Palani, Anandan, Tsui, Hon-Chung, Reichard, Gregory, Paliwal, Sunil, Shih, Neng-Yang, Aslanian, Robert, Duffy, Ruth, Lachowicz, Jean, Varty, Geoffrey, Morgan, Cynthia, Liu, Fei, Nomeir, Amin

“…Modification of prototype NK 1 antagonist 2 resulted in the synthesis of a series of simple amides 6 and retroamides 9. These compounds were shown to be potent…”
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Cyclic urea derivatives as potent NK1 selective antagonists by SHUE, Ho-Jane, XIAO CHEN, PIWINSKI, John J, DUFFY, Ruth A, LACHOWICZ, Jean E, COFFIN, Vicki L, FEI LIU, NOMEIR, Amin A, MORGAN, Cynthia A, VARTY, Geoffrey B, SHIH, Neng-Yang, BLYTHIN, David J, PALIWAL, Sunil, LING LIN, DANLIN GU, SCHWERDT, John H, SHAH, Sapna, REICHARD, Gregory A

“…A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this…”
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Discovery of a novel, potent and orally active series of γ-lactams as selective NK1 antagonists by PALIWAL, Sunil, REICHARD, Gregory A, NOMEIR, Amin A, VARTY, Geoffrey B, SHIH, Neng-Yang, SHAH, Sapna, LACI WROBLESKI, Michelle, CHENG WANG, STENGONE, Carmine, TSUI, Hon-Chung, DONG XIAO, DUFFY, Ruth A, LACHOWICZ, Jean E

“…Strategic replacement of the nitrogen of the lead compound 1 in the original cyclic urea series with a carbon resulted in the discovery of a novel, potent and…”
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Discovery of a novel, potent and orally active series of gamma -lactams as selective NK sub(1) antagonists by Paliwal, Sunil, Reichard, Gregory A, Shah, Sapna, Wrobleski, Michelle Laci, Wang, Cheng, Stengone, Carmine, Tsui, Hon-Chung, Xiao, Dong, Duffy, Ruth A, Lachowicz, Jean E, Nomeir, Amin A, Varty, Geoffrey B, Shih, Neng-Yang

“…Strategic replacement of the nitrogen of the lead compound 1 in the original cyclic urea series with a carbon resulted in the discovery of a novel, potent and…”
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Discovery of a novel, potent and orally active series of γ-lactams as selective NK 1 antagonists by Paliwal, Sunil, Reichard, Gregory A., Shah, Sapna, Wrobleski, Michelle Laci, Wang, Cheng, Stengone, Carmine, Tsui, Hon-Chung, Xiao, Dong, Duffy, Ruth A., Lachowicz, Jean E., Nomeir, Amin A., Varty, Geoffrey B., Shih, Neng-Yang

“…Replacement of nitrogen of the cyclic urea lead 1 with a carbon led to identification of a more potent and orally efficacious γ-lactam series of selective NK 1…”
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