Search Results - "Paliga, K"

Sequential processing of the transmembrane chemokines CX3CL1 and CXCL16 by α- and γ-secretases by Schulte, A., Schulz, B., Andrzejewski, M.G., Hundhausen, C., Mletzko, S., Achilles, J., Reiss, K., Paliga, K., Weber, C., Rose John, S., Ludwig, A.

“…The chemokines CX3CL1/Fractalkine and CXCL16 are expressed as transmembrane molecules and can mediate cell–cell-adhesion. By proteolytic processing, CX3CL1 and…”
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What the evolution of the amyloid protein precursor supergene family tells us about its function by Coulson, E.J, Paliga, K, Beyreuther, K, Masters, C.L

“…The Alzheimer’s disease amyloid protein precursor (APP) gene is part of a multi-gene super-family from which sixteen homologous amyloid precursor-like proteins…”
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Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein by Weidemann, A, Paliga, K, Dürrwang, U, Czech, C, Evin, G, Masters, C. L, Beyreuther, K

“…Mutations in the presenilin genes are associated with early onset familial Alzheimer's disease and lead to increased accumulation of beta A4 peptide, the…”
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The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation by Eggert, Simone, Paliga, Krzysztof, Soba, Peter, Evin, Genevieve, Masters, Colin L, Weidemann, Andreas, Beyreuther, Konrad

“…Amyloid precursor protein (APP) processing is of major interest in Alzheimer's disease research, since sequential cleavages by beta- and gamma-secretase lead…”
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A Novel ε-Cleavage within the Transmembrane Domain of the Alzheimer Amyloid Precursor Protein Demonstrates Homology with Notch Processing by Weidemann, Andreas, Eggert, Simone, Reinhard, Friedrich B. M, Vogel, Markus, Paliga, Krzysztof, Baier, Gottfried, Masters, Colin L, Beyreuther, Konrad, Evin, Geneviève

“…Proteolytic processing of the transmembrane domain of the amyloid precursor protein (APP) is a key component of Alzheimer's disease pathogenesis. Using…”
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γ-Secretase Cleavage and Binding to FE65 Regulate the Nuclear Translocation of the Intracellular C-Terminal Domain (ICD) of the APP Family of Proteins by Walsh, Dominic M, Fadeeva, Julia V, LaVoie, Matthew J, Paliga, Krzysztof, Eggert, Simone, Kimberly, W. Taylor, Wasco, Wilma, Selkoe, Dennis J

“…Regulated intramembrane proteolysis (RIP) of the amyloid precursor protein (APP) produces amyloid β-protein (Aβ), the probable causative agent of Alzheimer's…”
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Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases by Weidemann, A, Paliga, K, Dürrwang, U, Reinhard, F B, Schuckert, O, Evin, G, Masters, C L

“…Alzheimer's disease is characterized by neurodegeneration and deposition of betaA4, a peptide that is proteolytically released from the amyloid precursor…”
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Identification of cis-Elements Regulating Exon 15 Splicing of the Amyloid Precursor Protein Pre-mRNA by Bergsdorf, Christian, Paliga, Krzysztof, Kreger, Sylvia, Masters, Colin L., Beyreuther, Konrad

“…Alternative splicing of exon 15 of the amyloid precursor protein (APP) pre-mRNA generates two APP isoform groups APPex15 (containing exon 15) and L-APP…”
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Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer's disease by BAYER, T. A, PALIGA, K, WEGGEN, S, WIESTLER, O. D, BEYREUTHER, K, MULTHAUP, G

“…The Alzheimer's disease (AD) beta-amyloid precursor protein (APP) and the amyloid precursor-like protein 1 (APLP1) and 2 (APLP2) are members of a super-family…”
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225 Cloning and characterization of the human amyloid precursor-like protein 1 (APLP1) by Paliga, K., Weidemann, A., Dürrwangs, U., Peraus, G.C., Kreger, S., Masters, C.L., Beyreuther, K.

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61 Characterization of transmembrane PS-2 proteins by expression of the wild-type gene and cDNAs bearing missense mutation by Weidemann, A., Dürrwang, U., Paliga, K., Czech, C., Masters, C.L., Bevreuther, K.

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783 Polymorphisms of the Presenilin 2 gene (PS2, STM2 or ES1) in German sporadic Alzheimer's disease patients by Zhang, D., Sandbrink, R., Tienari, P., Hartmann, T., Bergsdorf, C., Paliga, K., Förstl, H., Masters, C.L., Bevreuther, K.

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Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid by Paliga, K, Peraus, G, Kreger, S, Dürrwang, U, Hesse, L, Multhaup, G, Masters, C L, Beyreuther, K, Weidemann, A

“…Amyloid precursor-like protein 1 (APLP1) represents an integral membrane type 1 protein of unknown function which was originally cloned from a mouse cDNA…”
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45 Missense mutations of the Presenilin I (PSI or 5182) gene in German early-onset Alzheimer's disease Patients by Sandbrink, R., Zhang, D., Hartmann, T., Bergsdorf, C., Paliga, K., Schäffer, S., Bauer, J., Först, H., Bickel, H., Masters, C.L., Beyreuther, K.

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