Search Results - "Palfreyman, Malcolm N"

Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogs by Ashton, Michael J, Cook, David C, Fenton, Garry, Karlsson, Jan-Anders, Palfreyman, Malcolm N, Raeburn, David, Ratcliffe, Andrew J, Souness, John E, Thurairatnam, Suga, Vicker, Nigel

“…The syntheses and biological activities of a number of benzamide derivatives, designed from rolipram, which are selective inhibitors of cyclic AMP-specific…”
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Synthesis and biological activity of trans-(.+-.)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (RP 49356) and analogs: a new class of potassium channel opener by Brown, Thomas J, Chapman, Robert F, Cook, David C, Hart, Terance W, McLay, Iain M, Jordan, Roy, Mason, Jonathan S, Palfreyman, Malcolm N, Walsh, Roger J. A

“…The synthesis and biological activity of trans-(+-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamid+ ++ e 1-oxide (8a, RP 49356) and analogues is…”
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Syntheses and biological activities of potent potassium channel openers derived from (.+-.)-2-oxo-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide: new potassium channel openers by Brown, Thomas J, Chapman, Robert F, Mason, Jonathan S, Palfreyman, Malcolm N, Vicker, Nigel, Walsh, Roger J. A

“…The syntheses and biological activities of (+/-)-2-(cyanomethylene)-1-pyridin-3-ylcyclohexanecarbothioic++ + acid methylamide (6) and…”
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Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer by Souness, John E., Griffin, Miriam, Maslen, Christopher, Ebsworth, Karen, Scott, Lisa C., Pollock, Kenneth, Palfreyman, Malcolm N., Karlsson, Jan‐Anders

“…1 We have investigated the inhibitory effects of RP 73401 (piclamilast) and rolipram against human monocyte cyclic AMP‐specific phosphodiesterase (PDE4) in…”
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Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP‐specific phosphodiesterase: comparison with rolipram by Soilness, John E., Maslen, Christopher, Webber, Stephen, Foster, Martyn, Raeburn, David, Palfreyman, Malcolm N., Ashton, Michael J., Karlsson, Jan‐Anders

“…1 We have investigated the inhibitory potency of RP 73401, a novel, highly selective and potent inhibitor of cyclic AMP‐specific phosphodiesterase (PDE IV),…”
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Potential chemotherapeutic agents. Formation of 2,7-naphthyridones from nicotinamide derivatives by Palfreyman, M N, Wooldridge, K R

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