Search Results - "Palese, Peter"

Is a Universal Influenza Virus Vaccine Possible? by Nachbagauer, Raffael, Palese, Peter

“…Influenza viruses remain a severe burden to human health because of their contribution to overall morbidity and mortality. Current seasonal influenza virus…”
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Toward a Universal Influenza Virus Vaccine: Prospects and Challenges by Pica, Natalie, Palese, Peter

“…Current influenza virus vaccines are annually reformulated to elicit protection by generating an immune response toward the virus strains that are predicted to…”
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Overcoming Barriers in the Path to a Universal Influenza Virus Vaccine by Coughlan, Lynda, Palese, Peter

“…Influenza viruses are important pathogens which pose an ongoing threat to public health due to their ability to mutate and evade immunity elicited by prior…”
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Oncolytic Newcastle disease virus for cancer therapy: old challenges and new directions by Zamarin, Dmitriy, Palese, Peter

“…Newcastle disease virus (NDV) is an avian paramyxovirus, which has been demonstrated to possess significant oncolytic activity against mammalian cancers. This…”
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Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies by Krammer, Florian, Pica, Natalie, Hai, Rong, Margine, Irina, Palese, Peter

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Guiding the Immune Response against Influenza Virus Hemagglutinin toward the Conserved Stalk Domain by Hyperglycosylation of the Globular Head Domain by Eggink, Dirk, Goff, Peter H, Palese, Peter

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Making better influenza virus vaccines? by Palese, Peter

“…Killed and live influenza virus vaccines are effective in preventing and curbing the spread of disease, but new technologies such as reverse genetics could be…”
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Development of Influenza B Universal Vaccine Candidates Using the "Mosaic" Hemagglutinin Approach by Sun, Weina, Kirkpatrick, Ericka, Ermler, Megan, Nachbagauer, Raffael, Broecker, Felix, Krammer, Florian, Palese, Peter

“…Influenza B viruses cause seasonal epidemics and are a considerable burden to public health. However, protection by current seasonal vaccines is suboptimal due…”
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Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy by Zamarin, Dmitriy, Holmgaard, Rikke B, Subudhi, Sumit K, Park, Joon Seok, Mansour, Mena, Palese, Peter, Merghoub, Taha, Wolchok, Jedd D, Allison, James P

“…Preexisting lymphocytic infiltration of tumors is associated with superior prognostic outcomes in a variety of cancers. Recent studies also suggest that…”
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Influenza virus transmission is dependent on relative humidity and temperature by Lowen, Anice C, Mubareka, Samira, Steel, John, Palese, Peter

“…Using the guinea pig as a model host, we show that aerosol spread of influenza virus is dependent upon both ambient relative humidity and temperature. Twenty…”
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Expression of functional recombinant hemagglutinin and neuraminidase proteins from the novel H7N9 influenza virus using the baculovirus expression system by Margine, Irina, Palese, Peter, Krammer, Florian

“…The baculovirus expression system is a powerful tool for expression of recombinant proteins. Here we use it to produce correctly folded and glycosylated…”
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Oncolytic Specificity of Newcastle Disease Virus Is Mediated by Selectivity for Apoptosis-Resistant Cells by MANSOUR, Mena, PALESE, Peter, ZAMARIN, Dmitriy

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Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19 by Calisher, Charles, Carroll, Dennis, Colwell, Rita, Corley, Ronald B, Daszak, Peter, Drosten, Christian, Enjuanes, Luis, Farrar, Jeremy, Field, Hume, Golding, Josie, Gorbalenya, Alexander, Haagmans, Bart, Hughes, James M, Karesh, William B, Keusch, Gerald T, Lam, Sai Kit, Lubroth, Juan, Mackenzie, John S, Madoff, Larry, Mazet, Jonna, Palese, Peter, Perlman, Stanley, Poon, Leo, Roizman, Bernard, Saif, Linda, Subbarao, Kanta, Turner, Mike

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Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential by VARGA, Zsuzsanna T, GRANT, Alesha, MANICASSAMY, Balaji, PALESE, Peter

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Induction of broadly reactive anti-hemagglutinin stalk antibodies by an H5N1 vaccine in humans by Nachbagauer, Raffael, Wohlbold, Teddy John, Hirsh, Ariana, Hai, Rong, Sjursen, Haakon, Palese, Peter, Cox, Rebecca J, Krammer, Florian

“…Influenza virus infections are a major public health concern and cause significant morbidity and mortality worldwide. Current vaccines are effective but strain…”
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Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins by Heaton, Nicholas S., Sachs, David, Chen, Chi-Jene, Hai, Rong, Palese, Peter

“…The molecular basis for the diversity across influenza strains is poorly understood. To gain insight into this question, we mutagenized the viral genome and…”
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Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus by He, Wenqian, Tan, Gene S., Mullarkey, Caitlin E., Lee, Amanda J., Lam, Mannie Man Wai, Krammer, Florian, Henry, Carole, Wilson, Patrick C., Ashkar, Ali A., Palese, Peter, Miller, Matthew S.

“…The generation of strain-specific neutralizing antibodies against influenza A virus is known to confer potent protection against homologous infections. The…”
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A Recombinant Antibody-Expressing Influenza Virus Delays Tumor Growth in a Mouse Model by Hamilton, Jennifer R., Vijayakumar, Gayathri, Palese, Peter

“…Influenza A virus (IAV) has shown promise as an oncolytic agent. To improve IAV as an oncolytic virus, we sought to design a transgenic virus expressing an…”
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Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity by Zamarin, Dmitriy, Holmgaard, Rikke B., Ricca, Jacob, Plitt, Tamar, Palese, Peter, Sharma, Padmanee, Merghoub, Taha, Wolchok, Jedd D., Allison, James P.

“…Emerging data suggest that locoregional cancer therapeutic approaches with oncolytic viruses can lead to systemic anti-tumour immunity, although the…”
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Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins by Nachbagauer, Raffael, Choi, Angela, Hirsh, Ariana, Margine, Irina, Iida, Sayaka, Barrera, Aldo, Ferres, Marcela, Albrecht, Randy A, García-Sastre, Adolfo, Bouvier, Nicole M, Ito, Kimihito, Medina, Rafael A, Palese, Peter, Krammer, Florian

“…Antigenic drift and reassortment alters the epitopes of influenza virus. Krammer and colleagues reveal the cross-reactivity of antibody responses to viral…”
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