Search Results - "Palencia, Belen"

Intratumoral injection of IL-12-encoding mRNA targeted to CSF1R and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure by Di Trani, Claudia Augusta, Cirella, Assunta, Arrizabalaga, Leire, Alvarez, Maite, Bella, Ángela, Fernandez-Sendin, Myriam, Russo-Cabrera, Joan Salvador, Gomar, Celia, Ardaiz, Nuria, Teijeira, Alvaro, Bolaños, Elixabet, González-Gomariz, José, Otano, Itziar, Aranda, Fernando, Palencia, Belén, Segués, Aina, Huang, Shuyu, van Duijnhoven, Sander M.J., van Elsas, Andrea, Melero, Ignacio, Berraondo, Pedro

“…IL-12 is a potent cytokine for cancer immunotherapy. However, its systemic delivery as a recombinant protein has shown unacceptable toxicity in the clinic…”
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Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models by Di Trani, Claudia Augusta, Cirella, Assunta, Arrizabalaga, Leire, Bella, Ángela, Fernandez-Sendin, Myriam, Russo-Cabrera, Joan Salvador, Gomar, Celia, Olivera, Irene, Bolaños, Elizabeth, González-Gomariz, José, Álvarez, Maite, Etxeberria, Iñaki, Palencia, Belen, Teijeira, Álvaro, Melero, Ignacio, Berraondo, Pedro, Aranda, Fernando

“…Previous studies have shown that local delivery of tumor antigen-specific CD8 + T lymphocytes engineered to transiently express single-chain IL-12 mRNA is…”
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Dendritic cells delivered inside human carcinomas are sequestered by interleukin‐8 by Feijoó, Esperanza, Alfaro, Carlos, Mazzolini, Guillermo, Serra, Patricia, Peñuelas, Iván, Arina, Ainhoa, Huarte, Eduardo, Tirapu, Iñigo, Palencia, Belén, Murillo, Oihana, Ruiz, Juan, Sangro, Bruno, Richter, José A., Prieto, Jesús, Melero, Ignacio

“…In the course of a clinical trial consisting of intratumoral injections of dendritic cells (DCs) transfected to produce interleukin‐12, the use of…”
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Potentiation of Therapeutic Immune Responses against Malignancies with Monoclonal Antibodies by MURILLO, Oihana, ARINA, Ainhoa, TIRAPU, Inigo, ALFARO, Carlos, MAZZOLINI, Guillermo, PALENCIA, Belen, LOPEZ-DIAZ DE CERIO, Ascension, PRIETO, Jesus, BENDANDI, Maurizio, MELERO, Ignacio

“…Immunotherapeutic monoclonal antibodies (mAbs) can be defined as those that exert their functions by tampering with immune system cell molecules, causing an…”
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Intratumoral immunotherapy with mRNAs encoding chimeric protein constructs encompassing IL-12, CD137 agonists, and TGF-β antagonists by Cirella, Assunta, Bolaños, Elixabet, Luri-Rey, Carlos, Di Trani, Claudia Augusta, Olivera, Irene, Gomis, Gabriel, Glez-Vaz, Javier, Pinci, Beatrice, Garasa, Saray, Sánchez-Gregorio, Sandra, Azpilikueta, Arantza, Eguren-Santamaria, Iñaki, Valencia, Karmele, Palencia, Belén, Alvarez, Maite, Ochoa, Maria C., Teijeira, Álvaro, Berraondo, Pedro, Melero, Ignacio

“…Intratumoral immunotherapy strategies for cancer based on interleukin-12 (IL-12)-encoding cDNA and mRNA are under clinical development in combination with…”
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CD137 (4-1BB) and T-Lymphocyte Exhaustion by Molero-Glez, Paula, Azpilikueta, Arantza, Mosteo, Laura, Glez-Vaz, Javier, Palencia, Belen, Melero, Ignacio

“…CD137 (4-1BB) costimulation results in the potent activation of antitumor T lymphocytes and elicits antitumor efficacy that is synergistic with anti-PD(L)1…”
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Novel strategies exploiting interleukin-12 in cancer immunotherapy by Cirella, Assunta, Luri-Rey, Carlos, Di Trani, Claudia Augusta, Teijeira, Alvaro, Olivera, Irene, Bolaños, Elixabet, Castañón, Eduardo, Palencia, Belen, Brocco, Davide, Fernández-Sendin, Myriam, Aranda, Fernando, Berraondo, Pedro, Melero, Ignacio

“…Interleukin-12 is considered a potent agent to enhance antitumor immune responses. It belongs to a family of heterodimeric cytokines with key roles in the…”
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Intratumoral injection of IL-12-encoding mRNA targeted to CSFR1 and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure by Di Trani, Claudia Augusta, Cirella, Assunta, Arrizabalaga, Leire, Alvarez, Maite, Bella, Ángela, Fernandez-Sendin, Myriam, Russo-Cabrera, Joan Salvador, Gomar, Celia, Ardaiz, Nuria, Teijeira, Alvaro, Bolaños, Elixabet, González-Gomariz, José, Otano, Itziar, Aranda, Fernando, Palencia, Belén, Segués, Aina, Huang, Shuyu, van Duijnhoven, Sander M J, van Elsas, Andrea, Melero, Ignacio, Berraondo, Pedro

“…IL-12 is a potent cytokine for cancer immunotherapy. However, its systemic delivery as a recombinant protein has shown unacceptable toxicity in the clinic…”
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Facts and Hopes on Neutralization of Protumor Inflammatory Mediators in Cancer Immunotherapy by Olivera, Irene, Luri-Rey, Carlos, Teijeira, Alvaro, Eguren-Santamaria, Iñaki, Gomis, Gabriel, Palencia, Belen, Berraondo, Pedro, Melero, Ignacio

“…In cancer pathogenesis, soluble mediators are responsible for a type of inflammation that favors the progression of tumors. The mechanisms chiefly involve…”
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Intratumoural administration of dendritic cells: hostile environment and help by gene therapy by Huarte, Eduardo, Tirapu, Iñigo, Arina, Ainhoa, Vera, María, Alfaro, Carlos, Murillo, Oihana, Palencia, Belén, Busto, Victoria, Marín, Verónica, Mazzolini, Guillermo, Melero, Ignacio

“…Like paratroopers in special operations, dendritic cells (DCs) can be deployed behind the enemy borders of malignant tissue to ignite an antitumour immune…”
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Low-dose ionizing γ-radiation elicits the extrusion of neutrophil extracellular traps by Teijeira, Alvaro, Garasa, Saray, Ochoa, Maria C, Sanchez-Gregorio, Sandra, Gomis, Gabriel, Luri-Rey, Carlos, Martinez-Monge, Rafael, Pinci, Beatrice, Valencia, Karmele, Palencia, Belen, Barbes, Benigno, Bolanos, Elixabet, Azpilikueta, Arantza, Garcia-Cardosa, Marina, Burguete, Javier, Eguren-Santamaria, Iñaki, Garate-Soraluze, Eneko, Berraondo, Pedro, Perez-Gracia, Jose L, de Andrea, Carlos E, Rodriguez-Ruiz, Maria E, Melero, Ignacio

“…Cancer patients frequently undergo radiotherapy in their clinical management with unintended irradiation of blood vessels and copiously irrigated organs in…”
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Intratumoral Gene Transfer of mRNAs Encoding IL12 in Combination with Decoy-Resistant IL18 Improves Local and Systemic Antitumor Immunity by Cirella, Assunta, Bolaños, Elixabet, Di Trani, Claudia Augusta, de Andrea, Carlos E, Sánchez-Gregorio, Sandra, Etxeberria, Iñaki, Gonzalez-Gomariz, Jose, Olivera, Irene, Brocco, Davide, Glez-Vaz, Javier, Luri-Rey, Carlos, Azpilikueta, Arantza, Rodríguez, Inmaculada, Fernandez-Sendín, Myriam, Egea, Josune, Eguren, Iñaki, Sanmamed, Miguel F, Palencia, Belen, Teijeira, Alvaro, Berraondo, Pedro, Melero, Ignacio

“…IL12-based local gene therapy of cancer constitutes an active area of clinical research using plasmids, mRNAs, and viral vectors. To improve antitumor effects,…”
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Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer by Arina, Ainhoa, Murillo, Oihana, Dubrot, Juan, Azpilikueta, Arantza, Alfaro, Carlos, Pérez-Gracia, Jose L, Bendandi, Maurizio, Palencia, Belen, Hervás-Stubbs, Sandra, Melero, Ignacio

“…There is compelling evidence for the role of natural killer (NK) cells in tumor immunosurveillance and their beneficial effects on many experimentally…”
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Effective tumor immunotherapy: start the engine, release the brakes, step on the gas pedal,...and get ready to face autoimmunity by Tirapu, Iñigo, Mazzolini, Guillermo, Rodriguez-Calvillo, Mercedes, Arina, Ainhoa, Palencia, Belen, Gabari, Izaskun, Melero, Ignacio

“…Cellular immune responses can destroy cancer cells, achieving the cure of experimental malignancies. An expanding wealth of knowledge on the molecular basis of…”
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Interferon producing killer dendritic cells (IKDC): A matter of controversy by Morales, Aizea, Ochoa, Carmen, Palazón, Asís, Dubrot, Juan, Palencia, Belén, Alfaro, Carlos, Suarez, Natalia, Martínez Forero, Iván, Hervás-Stubbs, Sandra, Melero, Ignacio

“…Abstract Division of labour among cells of the immune system is a prevailing theme in the orchestration of immune responses. Contrary to this paradigm, a…”
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Potenciales evocados cognitivos en el trastorno por déficit de atención con hiperactividad by Idiazábal Alecha, Mª Ángeles, Palencia Taboada, Ana Belén, Sangorrín García, Javier, Espadaler Gamissans, Josep Maria

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