Search Results - "Palen, Katie"

Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models by Tsai, Susan, McOlash, Laura, Palen, Katie, Johnson, Bryon, Duris, Christine, Yang, Qiuhui, Dwinell, Michael B, Hunt, Bryan, Evans, Douglas B, Gershan, Jill, James, Michael A

“…Patient-derived tumor models are the new standard for pre-clinical drug testing and biomarker discovery. However, the emerging technology of primary pancreatic…”
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Cancer chemoprevention with PV-1, a novel Prunella vulgaris -containing herbal mixture that remodels the tumor immune microenvironment in mice by Zhang, Qi, Chen, Xu, Palen, Katie, Johnson, Bryon, Bui, Dinh, Xiong, Donghai, Pan, Jing, Hu, Ming, Wang, Yian, You, Ming

“…The herb has shown significant immune-stimulatory and anti-inflammatory effects in mouse models. Here, the effects of a novel -containing herbal mixture, PV-1,…”
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Precision immunointerception of EGFR-driven tumorigenesis for lung cancer prevention by Pan, Jing, Xiong, Donghai, Zhang, Qi, Palen, Katie, Shoemaker, Robert H, Johnson, Bryon, Sei, Shizuko, Wang, Yian, You, Ming

“…Epidermal growth factor receptor (EGFR) mutations occur in about 50% of lung adenocarcinomas in Asia and about 15% in the US. EGFR mutation-specific inhibitors…”
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Potentiation of Kras peptide cancer vaccine by avasimibe, a cholesterol modulator by Pan, Jing, Zhang, Qi, Palen, Katie, Wang, Li, Qiao, Lifen, Johnson, Bryon, Sei, Shizuko, Shoemaker, Robert H., Lubet, Ronald A., Wang, Yian, You, Ming

“…No effective approaches to target mutant Kras have yet been developed. Immunoprevention using KRAS-specific antigenic peptides to trigger T cells capable of…”
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Striking efficacy of a vaccine targeting TOP2A for triple-negative breast cancer immunoprevention by Lee, Sang Beom, Pan, Jing, Xiong, Donghai, Palen, Katie, Johnson, Bryon, Lubet, Ronald A., Shoemaker, Robert H., Green, Jeffrey E., Fernando, Romaine Ingrid, Sei, Shizuko, You, Ming, Wang, Yian

“…Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that has a poor prognosis. TOP2A is a key enzyme in DNA replication and is a…”
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Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA by Pan, Jing, Chen, Yao, Zhang, Qi, Khatun, Achia, Palen, Katie, Xin, Gang, Wang, Li, Yang, Chuanjia, Johnson, Bryon D., Myers, Charles R., Sei, Shizuko, Shoemaker, Robert H., Lubet, Ronald A., Wang, Yian, Cui, Weiguo, You, Ming

“…Expressed on cells of the myeloid and lymphoid lineages, V-domain Ig Suppressor of T cell Activation (VISTA) is an emerging target for cancer immunotherapy…”
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Adoptive cell therapy using PD-1 + myeloma-reactive T cells eliminates established myeloma in mice by Jing, Weiqing, Gershan, Jill A, Blitzer, Grace C, Palen, Katie, Weber, James, McOlash, Laura, Riese, Matthew, Johnson, Bryon D

“…Adoptive cellular therapy (ACT) with cancer antigen-reactive T cells following lymphodepletive pre-conditioning has emerged as a potentially curative therapy…”
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Tumor antigen analysis in neuroblastoma by serological interrogation of bioinformatic data by Kohler, M. Eric, Johnson, Bryon D., Palen, Katie, Chen, Qing‐Rong, Khan, Javed, Orentas, Rimas J.

“…The identification of tumor antigens remains a major objective in tumor immunology, especially in pediatric malignancies where solid tumors often do not…”
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Erratum to: Separation and Characterization of Epithelial and Mesenchymal-like Murine Mammary Tumor Cells Reveals Epithelial Cell Differentiation Plasticity and Enhanced Tumorigenicity of Epithelial-enriched Tumor Cells by Palen, Katie A., Jing, Weiqing, Weber, James J., Tilkens, Sara B., Chan, Andrew M., Johnson, Bryon D., Gershan, Jill A.

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Separation and Characterization of Epithelial and Mesenchymal-like Murine Mammary Tumor Cells Reveals Epithelial Cell Differentiation Plasticity and Enhanced Tumorigenicity of Epithelial-enriched Tumor Cells by Palen, Katie A., Jing, Weiqing, Weber, James J., Tilkens, Sara B., Chan, Andrew M., Johnson, Bryon D., Gershan, Jill A.

“…Tumors are composed of heterogeneous populations of cells including tumor-initiating cells (TICs) and metastatic precursors. While the origin of these cells is…”
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Successful Manufacturing of CAR T-Cells with Small Volume Peripheral Blood from Healthy Donors Using the Clinimacs Prodigy Device by Palen, Katie, Hari, Parameswaran, Shah, Nirav N., Johnson, Bryon

“…Introduction In recent years, CAR T-cell therapy has emerged as a potentially curative intent treatment for some patients with relapsed, refractory hematologic…”
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ABCL-720 Combination of Pirtobrutinib and Lentiviral Transduced Bispecific Anti-CD20/CD19 (LV20.19) CAR T-Cell Therapy to Improve Outcomes in Patients With Relapsed/Refractory Lymphoma by Furqan, Fateeha, Palen, Katie, Kearl, Tyce, Hematti, Pieman, Hamadani, Mehdi, Fenske, Timothy, Shah, Nirav

“…Trials combining BTK inhibitors (BTKis) with CAR-T have suggested potential synergistic benefit by improving CAR-T immunophenotype and outcomes but are limited…”
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Combination of Pirtobrutinib and Lentiviral Transduced Bispecific Anti-CD20/CD19 (LV20 .19) CAR T-Cell Therapy to Improve Outcomes in Patients With Relapsed/Refractory Lymphoma by Furqan, Fateeha, Palen, Katie, Johnson, Bryon, Kearl, Tyce, Hematti, Pieman, Hamadani, Mehdi, Fenske, Timothy, Shah, Nirav

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Dual Targeting of Slamf-7 and CD38 in Mulitple Myeloma (MM): A Phase II Study of Isatuximab, Elotuzumab, Pomalidomide and Dexamethasone (Isa-EloPD) in Relapsed and/or Refractory MM (RRMM) by Dhakal, Binod, Mohan, Meera, Narra, Ravi, Palen, Katie, Szabo, Aniko, Kearl, Tyce, Ravi, Gayathri, Bal, Susan, Johnson, Bryon D., Pasquini, Marcelo, D'Souza, Anita, Hari, Parameswaran N., Costa, Luciano

“…Background: Elotuzumab (Elo) is a humanized IgG1 mAb that targets SLAMF7, an antigen highly expressed on malignant plasma cells. Isatuximab (Isa) is a…”
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Manufacturing chimeric antigen receptor T cells from cryopreserved peripheral blood cells: time for a collect-and-freeze model? by Palen, Katie, Zurko, Joanna, Johnson, Bryon D., Hari, Parameswaran, Shah, Nirav N.

“…Chimeric antigen receptor (CAR)-modified T-cell therapy has revolutionized outcomes for patients with relapsed/refractory B-cell malignancies. Despite the…”
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STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models by Jing, Weiqing, McAllister, Donna, Vonderhaar, Emily P, Palen, Katie, Riese, Matthew J, Gershan, Jill, Johnson, Bryon D, Dwinell, Michael B

“…Pancreatic cancer is characterized by an immune suppressive stromal reaction that creates a barrier to therapy. A murine transgenic pancreatic cancer cell line…”
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Abstract IA015: Immunoprevention of triple negative breast cancer by TOP2A derived peptide vaccination by Lee, Sang Beom, Pan, Jing, Xiong, Donghai, Palen, Katie, Johnson, Bryon, Green, Jeffrey E., Sei, Shizuko, Shoemaker, Robert H., Lubet, Ronald A., Wang, Yian, You, Ming

“…Abstract Top2A is a key enzyme involved in DNA replication and is a therapeutic target for several cancer types including breast cancer. Overexpression of…”
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Abstract 4584: A novel combination of a multipeptide KRAS vaccine and an ACAT1 inhibitor to prevent lung cancer by Pan, Jing, Zhang, Qi, Palen, Katie, Johnson, Bryon, Wang, Li, Sei, Shizuko, Shoemaker, Robert H., Lubet, Ronald A., Wang, Yian, You, Ming

“…Abstract Kirsten rat sarcoma viral oncogene homolog (KRAS) gene encodes a small GTPase that cycles between GDP and GTP-bound states, which modulates important…”
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Bone Marrow-derived CD8+ T Cells From Pediatric Leukemia Patients Express PD1 and Expand Ex Vivo Following Induction Chemotherapy by Palen, Katie, Thakar, Monica, Johnson, Bryon D, Gershan, Jill A

“…Adoptive cell therapy (ACT) of chimeric antigen receptor T cells has demonstrated remarkable success for the treatment of pediatric B-cell leukemia. For…”
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Abstract 1618: Inhibition of lung tumorigenesis by a novel small molecule CA170 targeting the immune checkpoint protein VISTA by Pan, Jing, Chen, Yao, Zhang, Qi, Khatun, Achia, Palen, Katie, Wang, Li, Yang, Chuanjia, Johnson, Bryon D., Myers, Charles R., Sei, Shizuko, Shoemaker, Robert H., Lubet, Ronald A., Wang, Yian, Cui, Weiguo, You, Ming

“…Abstract Immunotherapy using monoclonal antibodies to block immune checkpoints is becoming a mainstream therapy for multiple late-stage cancers owing to their…”
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