Search Results - "Palej Jakopović, Ivana"
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Synthesis of macrolones with central piperazine ring in the linker and its influence on antibacterial activity
Published in Bioorganic & medicinal chemistry (01-12-2011)“…Three macrolides, clarithromycin, azithromycin and 11-O-Me-azithromycin have been selected for the construction of a series of new macrolone derivatives…”
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Ethers from esters; from exceptional transformation to synthetic method
Published in ARKIVOC free online journal of organic chemistry (01-01-2015)Get full text
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Novel desosamine-modified 14- and 15-membered macrolides without antibacterial activity
Published in Bioorganic & medicinal chemistry letters (15-05-2012)“…Novel modifications of the desosamine sugar of 14- and 15-membered antibacterial macrolides, in which the desosamine was fused with…”
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Initial Scale-Up and Process Improvements for the Preparation of a Lead Antibacterial Macrolone Compound
Published in Organic process research & development (19-11-2010)“…Macrolones are a novel class of potent antimicrobial agents that consist of a macrolide scaffold to which a quinolone unit is tethered by various linkers to…”
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Around the macrolide – Impact of 3D structure of macrocycles on lipophilicity and cellular accumulation
Published in European journal of medicinal chemistry (16-06-2017)“…The aim of this study was to investigate lipophilicity and cellular accumulation of rationally designed azithromycin and clarithromycin derivatives at the…”
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Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones
Published in European journal of medicinal chemistry (01-08-2011)“…Synthesis, antibacterial activity and pharmacokinetic properties of a novel class of macrolide antibiotics—macrolones—derived from azithromycin, comprising…”
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Synthesis and properties of macrolones characterized by two ether bonds in the linker
Published in Bioorganic & medicinal chemistry (01-09-2010)“…In this paper synthesis of macrolones 1– 18 starting from azithromycin is reported. Two key steps in the construction of the linker between macrolide and…”
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Ethers from esters; from exceptional transformationto synthetic method
Published in ARKIVOC (24-03-2015)Get full text
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