Search Results - "Palei, Ana C."

Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms by Spradley, Frank T, Palei, Ana C, Granger, Joey P

“…Preeclampsia (PE) is a pregnancy-specific disorder typically presenting as new-onset hypertension and proteinuria. While numerous epidemiological studies have…”
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Placental Ischemia Says "NO" to Proper NOS-Mediated Control of Vascular Tone and Blood Pressure in Preeclampsia by Palei, Ana C, Granger, Joey P, Spradley, Frank T

“…In this review, we first provide a brief overview of the nitric oxide synthase (NOS) isoforms and biochemistry. This is followed by describing what is known…”
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Recent Advances in the Understanding of the Pathophysiology of Preeclampsia by WARRINGTON, Junie P, GEORGE, Eric M, PALEI, Ana C, SPRADLEY, Frank T, GRANGER, Joey P

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Sildenafil attenuates placental ischemia-induced hypertension by George, Eric M, Palei, Ana C, Dent, Edward A, Granger, Joey P

“…Preeclampsia is a complication of pregnancy that is marked by hypertension, proteinuria, and maternal endothelial dysfunction. A central factor in the etiology…”
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Reduced uterine perfusion pressure induces hypertension in the pregnant mouse by Intapad, Suttira, Warrington, Junie P, Spradley, Frank T, Palei, Ana C, Drummond, Heather A, Ryan, Michael J, Granger, Joey P, Alexander, Barbara T

“…Despite preeclampsia being one of the leading causes of maternal death and a major contributor of maternal and perinatal morbidity, the mechanisms responsible…”
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Circulating Total Cell-Free DNA Levels Are Increased in Hypertensive Disorders of Pregnancy and Associated with Prohypertensive Factors and Adverse Clinical Outcomes by Amaral, Lorena M, Sandrim, Valeria C, Kutcher, Matthew E, Spradley, Frank T, Cavalli, Ricardo C, Tanus-Santos, Jose E, Palei, Ana C

“…Previous studies have described increased circulating cell-free DNA (cfDNA) in hypertensive disorders of pregnancy (HDP). Here, we aimed first to confirm this…”
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Functional polymorphisms of NOS3 and GUCY1A3 affect both nitric oxide formation and association with hypertensive disorders of pregnancy by Pereira, Daniela A, Luizon, Marcelo R, Palei, Ana C, Tanus-Santos, José E, Cavalli, Ricardo C, Sandrim, Valeria C

“…Impaired nitric oxide (NO) formation may be associated with endothelial dysfunction and increased cardiovascular disease risk in preeclampsia (PE). Functional…”
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Nitric Oxide Formation Is Inversely Related to Serum Levels of Antiangiogenic Factors Soluble Fms-Like Tyrosine Kinase-1 and Soluble Endogline in Preeclampsia by Sandrim, Valeria C, Palei, Ana C.T, Metzger, Ingrid F, Gomes, Valeria A, Cavalli, Ricardo C, Tanus-Santos, Jose E

“…Deficient NO formation has been implicated in hypertensive disorders of pregnancy. However, no previous study has compared the circulating nitrite…”
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Immune Mechanisms Linking Obesity and Preeclampsia by Spradley, Frank T, Palei, Ana C, Granger, Joey P

“…Preeclampsia (PE) is characterized by hypertension occurring after the twentieth week of pregnancy. It is a significant contributor to maternal and perinatal…”
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Antihypertensive therapy responsiveness and adverse outcomes in preeclampsia: insights into molecular mechanisms underlying cardiovascular and renal complications by Luizon, Marcelo R, Pereira, Daniela A, Mamede, Izabela, Ceron, Carla S, Cavalli, Ricardo C, Palei, Ana C, Sandrim, Valeria C

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Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences by Chatre, Laurent, Ducat, Aurélien, Spradley, Frank T., Palei, Ana C., Chéreau, Christiane, Couderc, Betty, Thomas, Kamryn C., Wilson, Anna R., Amaral, Lorena M., Gaillard, Irène, Méhats, Céline, Lagoutte, Isabelle, Jacques, Sébastien, Miralles, Francisco, Batteux, Frédéric, Granger, Joey P., Ricchetti, Miria, Vaiman, Daniel

“…Preeclampsia (PE) is a high-prevalence pregnancy disease characterized by placental insufficiency, gestational hypertension, and proteinuria. Overexpression of…”
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Sustained Elevated Circulating Activin A Impairs Global Longitudinal Strain in Pregnant Rats: A Potential Mechanism for Preeclampsia-Related Cardiac Dysfunction by Bakrania, Bhavisha A, Palei, Ana C, Bhattarai, Umesh, Chen, Yingjie, Granger, Joey P, Shahul, Sajid

“…Mediators of cardiac injury in preeclampsia are not well understood. Preeclamptic women have decreased cardiac global longitudinal strain (GLS), a sensitive…”
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Plasma eNOS Concentration in Healthy Pregnancy and in Hypertensive Disorders of Pregnancy: Evidence of Reduced Concentrations in Pre-Eclampsia from Two Independent Studies by Kaihara, Julyane N. S, Minami, Caroline K, Peraçoli, Maria T. S, Romão-Veiga, Mariana, Ribeiro-Vasques, Vanessa R, Peraçoli, José C, Palei, Ana C. T, Cavalli, Ricardo C, Nunes, Priscila R, Luizon, Marcelo R, Sandrim, Valeria C

“…Hypertensive disorders of pregnancy (HDP), comprising gestational hypertension (GH) and pre-eclampsia (PE), are leading causes of maternal and perinatal…”
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Pharmacogenetics in the treatment of pre-eclampsia: current findings, challenges and perspectives by Luizon, Marcelo R, Palei, Ana CT, Cavalli, Ricardo C, Sandrim, Valeria C

“…Pre-eclampsia (PE) is defined as pregnancy-induced hypertension and proteinuria, and is a major cause of maternal and perinatal morbidity and mortality. A…”
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Cell-free DNA as a potential biomarker for preeclampsia by Palei, Ana C

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Association between matrix metalloproteinase (MMP)-2 polymorphisms and MMP-2 levels in hypertensive disorders of pregnancy by Palei, Ana C.T., Sandrim, Valeria C., Amaral, Lorena M., Machado, Jackeline S.R., Cavalli, Ricardo C., Duarte, Geraldo, Tanus-Santos, Jose E.

“…We examined whether two functional polymorphisms (g.-1306C>T and g.-735C>T) in matrix metalloproteinase (MMP)-2 gene are associated with preeclampsia (PE) or…”
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Vascular endothelial growth factor genotypes and haplotypes are associated with pre-eclampsia but not with gestational hypertension by Sandrim, Valeria C., Palei, Ana C. T., Cavalli, Ricardo C., Araújo, Francielle M., Ramos, Ester S., Duarte, Geraldo, Tanus-Santos, Jose E.

“…Vascular endothelial growth factor (VEGF) is relevant for normal pregnancy, and abnormalities in VEGF functions are associated with hypertensive disorders of…”
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Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia by Sandrim, Valeria C., Palei, Ana C.T., Sertorio, Jonas T., Cavalli, Ricardo C., Duarte, Geraldo, Tanus-Santos, Jose E.

“…Pre-eclampsia (PE) is associated with decreased nitric oxide (NO) formation. However, no previous study has examined whether genetic variations in the…”
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Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin by George, Eric M., Colson, Drew, Dixon, Jeremy, Palei, Ana C., Granger, Joey P.

“…One of the most prevalent complications of pregnancy is preeclampsia, a hypertensive disorder which is a leading cause of maternal and perinatal morbidity and…”
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Antihypertensive effects of inducible nitric oxide synthase inhibition in experimental pre‐eclampsia by Amaral, Lorena M., Pinheiro, Lucas C., Guimaraes, Danielle A., Palei, Ana C.T., Sertório, Jonas T., Portella, Rafael L., Tanus‐Santos, Jose E.

“…Upregulation of inducible nitric oxide synthase (iNOS) has been reported in both experimental and clinical hypertension. However, although pro‐inflammatory…”
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