Search Results - "Palecek, Jan J."

Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes by Palecek, Jan J., Gruber, Stephan

“…SMC/kleisin complexes form elongated annular structures, which are critical for chromosome segregation, genome maintenance, and the regulation of gene…”
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The interplay of homology‐directed repair pathways in the repair of zebularine‐induced DNA–protein crosslinks in Arabidopsis by Dvořák Tomaštíková, Eva, Vaculíková, Jitka, Štenclová, Veronika, Kaduchová, Kateřina, Pobořilová, Zuzana, Paleček, Jan J., Pecinka, Ales

“…SUMMARY DNA–protein crosslinks (DPCs) are highly toxic DNA lesions represented by proteins covalently bound to the DNA. Persisting DPCs interfere with…”
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NSE5 subunit interacts with distant regions of the SMC arms in the Physcomitrium patens SMC5/6 complex by Vaculíková, Jitka, Holá, Marcela, Králová, Barbora, Lelkes, Edit, Štefanovie, Barbora, Vágnerová, Radka, Angelis, Karel J., Paleček, Jan J.

“…SUMMARY Structural maintenance of chromosome (SMC) complexes play roles in cohesion, condensation, replication, transcription, and DNA repair. Their cores are…”
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Characterisation of the Arabidopsis thaliana telomerase TERT-TR complex by Štefanovie, Barbora, Jenner, Leon P., Bozděchová, Lucie, Fajkus, Petr, Sýkorová, Eva, Fajkus, Jiří, Paleček, Jan J.

“…Most eukaryotic organisms employ a telomerase complex for the maintenance of chromosome ends. The core of this complex is composed of telomerase reverse…”
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SMC5/6: Multifunctional Player in Replication by Palecek, Jan J

“…The genome replication process is challenged at many levels. Replication must proceed through different problematic sites and obstacles, some of which can…”
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A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6 by Vondrova, Lucie, Kolesar, Peter, Adamus, Marek, Nociar, Matej, Oliver, Antony W., Palecek, Jan J.

“…The SMC (Structural Maintenance of Chromosomes) complexes are composed of SMC dimers, kleisin and kleisin-interacting (HAWK or KITE) subunits. Mutual…”
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Characterization of the conserved features of the NSE6 subunit of the Physcomitrium patens SMC5/6 complex by Lelkes, Edit, Jemelková, Jitka, Holá, Marcela, Štefanovie, Barbora, Kolesár, Peter, Vágnerová, Radka, Dvořák Tomaštíková, Eva, Pecinka, Ales, Angelis, Karel J., Paleček, Jan J.

“…SUMMARY Structural maintenance of chromosomes (SMC) complexes are molecular machines ensuring chromatin organization at higher levels. They play direct roles…”
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Analysis of BRCT5 domain-containing proteins reveals a new component of DNA damage repair in Arabidopsis by Vladejić, Jovanka, Yang, Fen, Dvořák Tomaštíková, Eva, Doležel, Jaroslav, Palecek, Jan J, Pecinka, Ales

“…The integrity of plant genetic information is constantly challenged by various internal and external factors. Therefore, plants use a sophisticated molecular…”
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Correction: Kolesar et al. Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase. Cells 2022, 11 , 165 by Kolesar, Peter, Stejskal, Karel, Potesil, David, Murray, Johanne M, Palecek, Jan J

“…In the original publication [...]…”
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Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase by Kolesar, Peter, Stejskal, Karel, Potesil, David, Murray, Johanne M, Palecek, Jan J

“…Structural Maintenance of Chromosomes (SMC) complexes are important for many aspects of the chromosomal organization. Unlike cohesin and condensin, the SMC5/6…”
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Visual Analysis of Protein-Protein Interaction Docking Models Using COZOID Tool by Byska, Jan, Jurcik, Adam, Furmanova, Katarina, Kozlikova, Barbora, Palecek, Jan J

“…Networks of protein-protein interactions (PPI) constitute either stable or transient complexes in every cell. Most of the cellular complexes keep their…”
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Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA by Zabrady, Katerina, Adamus, Marek, Vondrova, Lucie, Liao, Chunyan, Skoupilova, Hana, Novakova, Marketa, Jurcisinova, Lenka, Alt, Aaron, Oliver, Antony W, Lehmann, Alan R, Palecek, Jan J

“…SMC5/6 is a highly conserved protein complex related to cohesin and condensin, which are the key components of higher-order chromatin structures. The SMC5/6…”
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COZOID: contact zone identifier for visual analysis of protein-protein interactions by Furmanová, Katarína, Byška, Jan, Gröller, Eduard M, Viola, Ivan, Paleček, Jan J, Kozlíková, Barbora

“…Studying the patterns of protein-protein interactions (PPIs) is fundamental for understanding the structure and function of protein complexes. The exploration…”
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The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex by Kozakova, Lucie, Vondrova, Lucie, Stejskal, Karel, Charalabous, Panagoula, Kolesar, Peter, Lehmann, Alan R, Uldrijan, Stjepan, Sanderson, Christopher M, Zdrahal, Zbynek, Palecek, Jan J

“…The MAGE (Melanoma-associated antigen) protein family members are structurally related to each other by a MAGE-homology domain comprised of 2 winged helix…”
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Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease by van der Crabben, Saskia N, Hennus, Marije P, McGregor, Grant A, Ritter, Deborah I, Nagamani, Sandesh C S, Wells, Owen S, Harakalova, Magdalena, Chinn, Ivan K, Alt, Aaron, Vondrova, Lucie, Hochstenbach, Ron, van Montfrans, Joris M, Terheggen-Lagro, Suzanne W, van Lieshout, Stef, van Roosmalen, Markus J, Renkens, Ivo, Duran, Karen, Nijman, Isaac J, Kloosterman, Wigard P, Hennekam, Eric, Orange, Jordan S, van Hasselt, Peter M, Wheeler, David A, Palecek, Jan J, Lehmann, Alan R, Oliver, Antony W, Pearl, Laurence H, Plon, Sharon E, Murray, Johanne M, van Haaften, Gijs

“…The structural maintenance of chromosomes (SMC) family of proteins supports mitotic proliferation, meiosis, and DNA repair to control genomic stability…”
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A Single Conserved Amino Acid Residue as a Critical Context-Specific Determinant of the Differential Ability of Mdm2 and MdmX RING Domains to Dimerize by Kosztyu, Pavlína, Slaninová, Iva, Valčíková, Barbora, Verlande, Amandine, Müller, Petr, Paleček, Jan J, Uldrijan, Stjepan

“…Mdm2 and MdmX are related proteins serving in the form of the Mdm2 homodimer or Mdm2/MdmX heterodimer as an E3 ubiquitin ligase for the tumor suppressor p53…”
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Correction: Kolesar et al. Role of Nse1 Subunit of SMC5/6 Complex as a Ubiquitin Ligase. ICells/I 2022, I11/I, 165 by Kolesar, Peter, Stejskal, Karel, Potesil, David, Murray, Johanne M, Palecek, Jan J

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The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex by Kozakova, Lucie, Vondrova, Lucie, Stejskal, Karel, Charalabous, Panagoula, Kolesar, Peter, Lehmann, Alan R, Uldrijan, Stjepan, Sanderson, Christopher M, Zdrahal, Zbynek, Palecek, Jan J

“…The MAGE (Melanoma-associated antigen) protein family members are structurally related to each other by a MAGE-homology domain comprised of 2 winged helix…”
Get full text