Search Results - "Palde, Prakash B"

Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase by Truong, Thu H, Ung, Peter Man-Un, Palde, Prakash B, Paulsen, Candice E, Schlessinger, Avner, Carroll, Kate S

“…Epidermal growth factor receptor (EGFR) is a target of signal-derived H2O2, and oxidation of active-site cysteine 797 to sulfenic acid enhances kinase…”
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A universal entropy-driven mechanism for thioredoxin–target recognition by Palde, Prakash B., Carroll, Kate S.

“…Cysteine residues in cytosolic proteins are maintained in their reduced state, but can undergo oxidation owing to posttranslational modification during redox…”
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Safe and Efficient Tetrazole Synthesis in a Continuous-Flow Microreactor by Palde, Prakash B., Jamison, Timothy F.

“…Safer flow: The synthesis of 5‐substituted tetrazoles in flow (see scheme) is safe, efficient, scalable, requires no metal promoter, and uses a near‐equimolar…”
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Dynamic Combinatorial Selection of Molecules Capable of Inhibiting the (CUG) Repeat RNA−MBNL1 Interaction In Vitro: Discovery of Lead Compounds Targeting Myotonic Dystrophy (DM1) by Gareiss, Peter C, Sobczak, Krzysztof, McNaughton, Brian R, Palde, Prakash B, Thornton, Charles A, Miller, Benjamin L

“…Myotonic dystrophy type 1 (DM1), the most common form of muscular dystrophy in adults, is an RNA-mediated disease. Dramatically expanded (CUG) repeats…”
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Selective Recognition of Alkyl Pyranosides in Protic and Aprotic Solvents by Palde, Prakash B, Gareiss, Peter C, Miller, Benjamin L

“…The design and synthesis of receptors capable of selective, noncovalent recognition of carbohydrates continues to be a signature challenge in bioorganic…”
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Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1 by Ryan, Kevin, Bolaňos, Ben, Smith, Marissa, Palde, Prakash B., Cuenca, Paulina Delgado, VanArsdale, Todd L., Niessen, Sherry, Zhang, Lianglin, Behenna, Douglas, Ornelas, Martha A., Tran, Khanh T., Kaiser, Stephen, Lum, Lawrence, Stewart, Al, Gajiwala, Ketan S.

“…Poly-ADP-ribosyltransferases play a critical role in DNA repair and cell death, and poly(ADP-ribosyl) polymerase 1 (PARP1) is a particularly important…”
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Substituted 4-methylquinolines as a new class of anti-tuberculosis agents by Jain, Rahul, Vaitilingam, Balasubramanian, Nayyar, Amit, Palde, Prakash B

“…We report synthesis and anti-tuberculosis activities of a series of novel ring-substituted quinolines. The most effective compound of the series 3d (MIC=6.25…”
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Functional Site Discovery in a Sulfur Metabolism Enzyme by Using Directed Evolution by Paritala, Hanumantharao, Palde, Prakash B., Carroll, Kate S.

“…In human pathogens, the sulfate assimilation pathway provides reduced sulfur for biosynthesis of essential metabolites, including cysteine and…”
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First-in-Class Inhibitors of Sulfur Metabolism with Bactericidal Activity against Non-Replicating M. tuberculosis by Palde, Prakash B., Bhaskar, Ashima, Pedró Rosa, Laura E., Madoux, Franck, Chase, Peter, Gupta, Vinayak, Spicer, Timothy, Scampavia, Louis, Singh, Amit, Carroll, Kate S.

“…Development of effective therapies to eradicate persistent, slowly replicating M. tuberculosis (Mtb) represents a significant challenge to controlling the…”
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Characterization of Specific N -α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library by Kung, Pei-Pei, Bingham, Patrick, Burke, Benjamin J., Chen, Qiuxia, Cheng, Xuemin, Deng, Ya-Li, Dou, Dengfeng, Feng, Junli, Gallego, Gary M., Gehring, Michael R., Grant, Stephan K., Greasley, Samantha, Harris, Anthony R., Maegley, Karen A., Meier, Jordan, Meng, Xiaoyun, Montano, Jose L., Morgan, Barry A., Naughton, Brigitte S., Palde, Prakash B., Paul, Thomas A., Richardson, Paul, Sakata, Sylvie, Shaginian, Alex, Sonnenburg, William K., Subramanyam, Chakrapani, Timofeevski, Sergei, Wan, Jinqiao, Yan, Wen, Stewart, Albert E.

“…Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technology screening. Biophysical and biochemical data as well as cocrystal…”
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Strategies for Recognition of Stem−Loop RNA Structures by Synthetic Ligands: Application to the HIV-1 Frameshift Stimulatory Sequence by Palde, Prakash B, Ofori, Leslie O, Gareiss, Peter C, Lerea, Jaclyn, Miller, Benjamin L

“…Production of the Gag-Pol polyprotein in human immunodeficiency virus (HIV) requires a −1 ribosomal frameshift, which is directed by a highly conserved RNA…”
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Synthesis and antimycobacterial activities of ring-substituted quinolinecarboxylic acid/ester analogues. Part 1 by Vaitilingam, Balasubramanian, Nayyar, Amit, Palde, Prakash B, Monga, Vikramdeep, Jain, Rahul, Kaur, Sukhraj, Singh, Prati Pal

“…The antimycobacterial activities of ring-substituted quinolinecarboxylic acids/esters (Series 1–4) against M. tuberculosis H37Rv strains are described. The…”
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Ring-substituted quinolines. Part 2: Synthesis and antimycobacterial activities of ring-substituted quinolinecarbohydrazide and ring-substituted quinolinecarboxamide analogues by Monga, Vikramdeep, Nayyar, Amit, Vaitilingam, Balasubramanian, Palde, Prakash B., Singh Jhamb, Sarbjit, Kaur, Sukhraj, Singh, Prati Pal, Jain, Rahul

“…The antimycobacterial activities of ring-substituted quinolinecarbohydrazide and ring-substituted quinolinecarboxamide analogues (series 1–5) against M…”
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Safe and Efficient Tetrazole Synthesis in a Continuous-Flow Microreactor by Palde, Prakash B., Jamison, Timothy F.

“…Die Durchfluss‐Synthese von 5‐substituierten Tetrazolen (siehe Schema) gelingt sicher und effizient, benötigt keinen Metallpromotor, kommt mit einer annähernd…”
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universal entropy-driven mechanism for thioredoxin–target recognition by Palde, Prakash B, Kate S. Carroll

“…Cysteine residues in cytosolic proteins are maintained in their reduced state, but can undergo oxidation owing to posttranslational modification during redox…”
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Safe and Efficient Tetrazole Synthesis in a Continuous‐Flow Microreactor by Palde, Prakash B., Jamison, Timothy F.

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Strategies for Recognition of Stem-loop RNA Structures by Synthetic Ligands: Application to the HIV-1 Frameshift Stimulatory Sequencei by Palde, Prakash B., Ofori, Leslie O., Gareiss, Peter C., Lerea, Jaclyn, Miller, Benjamin L.

“…Production of the Gag-Pol polyprotein in human immunodeficiency virus (HIV) requires a -1 ribosomal frameshift, which is directed by a highly conserved RNA…”
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Conformational and Structural Analysis of a ter-Cyclopentane Scaffold for Molecular Recognition by Gareiss, Peter C., Palde, Prakash B., Hubbard, Robert D., Miller, Benjamin L.

“…Well‐defined oligomers of cycloalkanes comprise a relatively unstudied class of organic compounds, and may have general utility in the development of receptors…”
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Corrigendum to “Ring-substituted quinolines. Part 2: Synthesis and antimycobacterial activities of ring-substituted quinolinecarbohydrazide and ring-substituted quinolinecarboxamide analogues”: [Bioorg. Med. Chem. 12 (2004) 6465] by Monga, Vikramdeep, Nayyar, Amit, Vaitilingam, Balasubramaniam, Palde, Prakash B., Jhamb, Sarbjit Singh, Kaur, Sukhraj, Singh, Prati Pal, Jain, R.

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