Takotsubo Multicenter Registry (REMUTA) - Clinical Aspects, In-Hospital Outcomes, and Long-Term Mortality

Takotsubo syndrome (TTS) is an acquired form of cardiomyopathy. National Brazilian data on this condition are scarce. The Takotsubo Multicenter Registry (REMUTA) is the first to include multicenter data on this condition in Brazil. To describe the clinical characteristics, prognosis, in-hospital tre...

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Published in:	Arquivos brasileiros de cardiologia Vol. 115; no. 2; pp. 207 - 216
Main Authors:	Almeida Junior, Gustavo Luiz Gouvêa de, Mansur Filho, João, Albuquerque, Denilson Campos de, Xavier, Sergio Salles, Pontes, Álvaro, Gouvêa, Elias Pimentel, Martins, Alexandre Bahia Barreiras, Nunes, Nágela S V, Carestiato, Lilian Vieira, Petriz, João Luiz Fernandes, Santos, Armando Márcio Gonçalves, Bandeira, Bruno Santana, Abufaiad, Bárbara Elaine de Jesus, Pacheco, Luciana da Camara, Oliveira, Maurício Sales de, Ribeiro Filho, Paulo Eduardo Campana, Sampaio, Pedro Paulo Nogueres, Duque, Gustavo Salgado, Camillis, Luiz Felipe, Marques, André Casarsa, Lourenço, Jr, Francisco Carlos, Palazzo, José Ricardo, Costa, Cláudio Ramos da, Silva, Bibiana Almeida da, Zukowski, Cleverson Neves, Garcia, Romulo Ribeiro, Zonis, Fernanda de Carvalho, Paula, Suzana Andressa Morais de, Ferrari, Carolina Gravano Ferraz, Rangel, Bruno Soares da Silva, Ferreira, Roberto Muniz, Mendes, Bárbara Ferreira da Silva, Castro, Isabela Ribeiro Carvalho de, Souza, Leonardo Giglio Gonçalves de, Araújo, Luiz Henrique Dos Santos, Giani, Alexandre
Format:	Journal Article
Language:	English
Published:	Brazil 28-08-2020
Subjects:	Aged Aged, 80 and over Brazil - epidemiology Female Hospital Mortality Hospitals Humans Middle Aged Registries Retrospective Studies Stroke Volume Takotsubo Cardiomyopathy - mortality Ventricular Function, Left Brazil
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Summary:	Takotsubo syndrome (TTS) is an acquired form of cardiomyopathy. National Brazilian data on this condition are scarce. The Takotsubo Multicenter Registry (REMUTA) is the first to include multicenter data on this condition in Brazil. To describe the clinical characteristics, prognosis, in-hospital treatment, in-hospital mortality, and mortality during 1 year of follow-up. This is an observational, retrospective registry study including patients admitted to the hospital with diagnosis of TTS and patients admitted for other reasons who developed this condition. Evaluated outcomes included triggering factor, analysis of exams, use of medications, complications, in-hospital mortality, and mortality during 1 year of follow-up. A significance level of 5% was adopted. The registry included 169 patients from 12 centers in the state of Rio de Janeiro, Brazil. Mean age was 70.9 ± 14.1 years, and 90.5% of patients were female; 63% of cases were primary TTS, and 37% were secondary. Troponin I was positive in 92.5% of patients, and median BNP was 395 (176.5; 1725). ST-segment elevation was present in 28% of patients. Median left ventricular ejection fraction was 40 (35; 48)%. We observed invasive mechanical ventilation in 25.7% of cases and shock in 17.4%. Mechanical circulatory support was used in 7.7%. In-hospital mortality was 10.6%, and mortality at 1 year of follow-up was 16.5%. Secondary TTS and cardiogenic shock were independent predictors of mortality. The results of the REMUTA show that TTS is not a benign pathology, as was once thought, especially regarding the secondary TTS group, which has a high rate of complications and mortality. (Arq Bras Cardiol. 2020; 115(2):207-216).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1678-4170
DOI:	10.36660/abc.20190166