Search Results - "Palazzo, Isabella"
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Gene regulatory networks controlling vertebrate retinal regeneration
Published in Science (American Association for the Advancement of Science) (20-11-2020)“…Injury induces retinal Müller glia of certain cold-blooded vertebrates, but not those of mammals, to regenerate neurons. To identify gene regulatory networks…”
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Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina
Published in Journal of neuroinflammation (06-06-2019)“…Microglia and inflammation have context-specific impacts upon neuronal survival in different models of central nervous system (CNS) disease. Herein, we…”
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Common and divergent gene regulatory networks control injury-induced and developmental neurogenesis in zebrafish retina
Published in Nature communications (20-12-2023)“…Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes through Müller glia (MG) reprogramming and asymmetric cell…”
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mTor signaling is required for the formation of proliferating Müller glia-derived progenitor cells in the chick retina
Published in Development (Cambridge) (01-06-2016)“…We investigate the roles of mTor signaling in the formation of Müller glia-derived progenitor cells (MGPCs) in the chick retina. During embryonic development,…”
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Patterns of NFkB activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina
Published in Experimental neurology (01-01-2023)“…Müller glia are a cellular source for neuronal regeneration in vertebrate retinas. However, the capacity for retinal regeneration varies widely across species…”
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NF-κB signaling regulates the formation of proliferating Müller glia-derived progenitor cells in the avian retina
Published in Development (Cambridge) (22-05-2020)“…Retinal regeneration is robust in some cold-blooded vertebrates, but this process is ineffective in warm-blooded vertebrates. Understanding the mechanisms that…”
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NF-κB signaling regulates the formation of proliferating Müller glia-derived progenitor cells in the avian retina
Published in Development (Cambridge) (01-05-2020)“…Retinal regeneration is robust in some cold-blooded vertebrates, but this process is ineffective in warm-blooded vertebrates. Understanding the mechanisms that…”
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NFkB‐signaling promotes glial reactivity and suppresses Müller glia‐mediated neuron regeneration in the mammalian retina
Published in Glia (01-07-2022)“…Müller glia (MG) in mammalian retinas are incapable of regenerating neurons after damage, whereas the MG in lower vertebrates regenerate functional neurons…”
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BMP‐ and TGFβ‐signaling regulate the formation of Müller glia‐derived progenitor cells in the avian retina
Published in Glia (01-10-2017)“…Müller glia‐derived progenitor cells (MGPCs) have the capability to regenerate neurons in the retinas of different vertebrate orders. The formation of MGPCs is…”
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Midkine is neuroprotective and influences glial reactivity and the formation of Müller glia‐derived progenitor cells in chick and mouse retinas
Published in Glia (01-06-2021)“…Recent studies suggest midkine (MDK) is involved in the development and regeneration of the zebrafish retina. We investigate the expression patterns of MDK and…”
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Regulating the formation of Müller glia-derived progenitor cells in the retina
Published in Glia (24-10-2024)“…We summarize recent findings in different animal models regarding the different cell-signaling pathways and gene networks that influence the reprogramming of…”
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Wnt/β‐catenin‐signaling and the formation of Müller glia‐derived progenitors in the chick retina
Published in Developmental neurobiology (Hoboken, N.J.) (01-09-2016)“…ABSTRACT Müller glia can be stimulated to de‐differentiate, proliferate, and form Müller glia‐derived progenitor cells (MGPCs) that are capable of producing…”
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Real world data of 177 Lutetium-PSMA-617 for metastatic castration resistant prostate cancer (mCRPC): Analysis of patients treated from 2 large reference centers
Published in Journal of clinical oncology (01-06-2024)“…e17050 Background: 177 Lu-PSMA-617 was recently approved for the treatment of patients with mCRPC in the USA. While treatment is associated with improved…”
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Modulation of Neuroinflammatory Signaling Enhances the Neurogenic Reprogramming Capacity of Müller Glia across Species
Published 01-01-2021“…Retinal degeneration is a leading cause of blindness. Progressive death of retinal neurons is irreversible and results in loss of vision. Currently, there are…”
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Regional vs. Global Myocardial Flow Reserve Discordance in CZT SPECT: Implications for Risk Stratification
Published in Journal of nuclear cardiology (01-08-2024)Get full text
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Ga-DOTA PET/CT: the first-line functional imaging modality in the management of patients with neuroendocrine tumors
Published in Radiologia brasileira (01-03-2022)Get full text
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Robust reprogramming of glia into neurons by inhibition of Notch signaling and nuclear factor I (NFI) factors in adult mammalian retina
Published in Science advances (12-07-2024)“…Generation of neurons through direct reprogramming has emerged as a promising therapeutic approach for treating neurodegenerative diseases. In this study, we…”
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IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease
Published in The Journal of clinical investigation (01-10-2011)“…Aging is a major risk factor for the progression of neurodegenerative diseases, including Huntington disease (HD). Reduced neuronal IGF1 or Irs2 signaling have…”
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