Search Results - "Palazón, Asis"

Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer by PALAZON, Asis, ARAGONES, Julián, MORALES-KASTRESANA, Aizea, DE LANDAZURI, Manuel Ortiz, MELERO, Ignacio

“…Both malignant and stromal components in tumors are influenced by the physiologic conditions of the microenvironment. Hypoxia is a prominent feature of solid…”
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Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism by Labiano, Sara, Palazón, Asis, Bolaños, Elixabet, Azpilikueta, Arantza, Sánchez-Paulete, Alfonso R., Morales-Kastresana, Aizea, Quetglas, Jose I., Perez-Gracia, José L., Gúrpide, Alfonso, Rodriguez-Ruiz, Maria, Aznar, M. Angela, Jure-Kunkel, Maria, Berraondo, Pedro, Melero, Ignacio

“…Hypoxia is a common feature in solid tumors that has been implicated in immune evasion. Previous studies from our group have shown that hypoxia upregulates the…”
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Palettes of Vaccines and Immunostimulatory Monoclonal Antibodies for Combination by Melero, Ignacio, Martinez-Forero, Ivan, Dubrot, Juan, Suarez, Natalia, Palazón, Asis, Chen, Lieping

“…Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering…”
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Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ by Dubrot, Juan, Milheiro, Francisca, Alfaro, Carlos, Palazón, Asis, Martinez-Forero, Ivan, Perez-Gracia, Jose L, Morales-Kastresana, Aizea, Romero-Trevejo, José L, Ochoa, María C, Hervás-Stubbs, Sandra, Prieto, Jesús, Jure-Kunkel, Maria, Chen, Lieping, Melero, Ignacio

“…Background/aims Cancer therapy with agonist anti-CD137 mAbs has been shown to induce immune-mediated tumor rejections in mice, and equivalent agents of this…”
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Intratumoral injection of interferon‐α and systemic delivery of agonist anti‐CD137 monoclonal antibodies synergize for immunotherapy by Dubrot, Juan, Palazón, Asis, Alfaro, Carlos, Azpilikueta, Arantza, Ochoa, María Carmen, Rouzaut, Ana, Martinez‐Forero, Iván, Teijeira, Alvaro, Berraondo, Pedro, Le Bon, Agnes, Hervás‐Stubbs, Sandra, Melero, Ignacio

“…CD137 artificial costimulation results in complete tumor rejection in several mouse models. Type I interferons (IFN) exert antitumor effects through an array…”
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Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells by Dubrot, Juan, Portero, Aitziber, Orive, Gorka, Hernández, Rosa María, Palazón, Asis, Rouzaut, Ana, Perez-Gracia, Jose L, Hervás-Stubbs, Sandra, Pedraz, Jose Luis, Melero, Ignacio

“…Immunostimulatory monoclonal antibodies are immunoglobulins directed toward surface proteins of immune system cells that augment the immune response against…”
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CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape by Rodriguez-Garcia, Alba, Palazon, Asis, Noguera-Ortega, Estela, Powell, Jr, Daniel J, Guedan, Sonia

“…Chimeric antigen receptor (CAR) T cell therapies have demonstrated remarkable efficacy for the treatment of hematological malignancies. However, in patients…”
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Intensive Pharmacological Immunosuppression Allows for Repetitive Liver Gene Transfer With Recombinant Adenovirus in Nonhuman Primates by Fontanellas, Antonio, Hervás-Stubbs, Sandra, Mauleón, Itsaso, Dubrot, Juan, Mancheño, Uxua, Collantes, María, Sampedro, Ana, Unzu, Carmen, Alfaro, Carlos, Palazón, Asis, Smerdou, Cristian, Benito, Alberto, Prieto, Jesús, Peñuelas, Iván, Melero, Ignacio

“…Repeated administration of gene therapies is hampered by host immunity toward vectors and transgenes. Attempts to circumvent antivector immunity include…”
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Structural Characterization of N‐Linked Glycans in the Receptor Binding Domain of the SARS‐CoV‐2 Spike Protein and their Interactions with Human Lectins by Lenza, Maria Pia, Oyenarte, Iker, Diercks, Tammo, Quintana, Jon Imanol, Gimeno, Ana, Coelho, Helena, Diniz, Ana, Peccati, Francesca, Delgado, Sandra, Bosch, Alexandre, Valle, Mikel, Millet, Oscar, Abrescia, Nicola G. A., Palazón, Asís, Marcelo, Filipa, Jiménez‐Osés, Gonzalo, Jiménez‐Barbero, Jesús, Ardá, Ana, Ereño‐Orbea, June

“…The glycan structures of the receptor binding domain of the SARS‐CoV2 spike glycoprotein expressed in human HEK293F cells have been studied by using NMR. The…”
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HIF Transcription Factors, Inflammation, and Immunity by Palazon, Asis, Goldrath, Ananda W., Nizet, Victor, Johnson, Randall S.

“…The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible factor (HIF) transcription factors; these play an integral role in the…”
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Essential complicity of perforin-granzyme and FAS-L mechanisms to achieve tumor rejection following treatment with anti-CD137 mAb by Morales-Kastresana, Aizea, Catalán, Elena, Hervás-Stubbs, Sandra, Palazón, Asis, Azpilikueta, Arantza, Bolaños, Elixabet, Anel, Alberto, Pardo, Julián, Melero, Ignacio

“…Treatment with agonist anti-CD137 (4-1BB) immunostimulatory monoclonal antibodies elicits complete tumor regressions in a number of transplanted hematological…”
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SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum by Bruzzone, Chiara, Bizkarguenaga, Maider, Gil-Redondo, Rubén, Diercks, Tammo, Arana, Eunate, García de Vicuña, Aitor, Seco, Marisa, Bosch, Alexandre, Palazón, Asís, San Juan, Itxaso, Laín, Ana, Gil-Martínez, Jon, Bernardo-Seisdedos, Ganeko, Fernández-Ramos, David, Lopitz-Otsoa, Fernando, Embade, Nieves, Lu, Shelly, Mato, José M., Millet, Oscar

“…COVID-19 is a systemic infection that exerts significant impact on the metabolism. Yet, there is little information on how SARS-CoV-2 affects metabolism. Using…”
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Therapeutic Antitumor Efficacy of Anti-CD137 Agonistic Monoclonal Antibody in Mouse Models of Myeloma by MURILLO, Oihana, ARINA, Ainhoa, SOLANO, Sarai, PEREZ-GRACIA, José L, OYAJOBI, Babatunde O, MELERO, Ignacio, HERVAS-STUBBS, Sandra, GUPTA, Anjana, MCCLUSKEY, Brandon, DUBROT, Juan, PALAZON, Asis, AZPILIKUETA, Arantza, OCHOA, Maria C, ALFARO, Carlos

“…Purpose: Eradication of post-treatment residual myeloma cells is needed to prevent relapses, and immunostimulatory monoclonal antibodies (mAb) such as…”
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Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment by Araujo, Angela M, Abaurrea, Andrea, Azcoaga, Peio, López-Velazco, Joanna I, Manzano, Sara, Rodriguez, Javier, Rezola, Ricardo, Egia-Mendikute, Leire, Valdés-Mora, Fátima, Flores, Juana M, Jenkins, Liam, Pulido, Laura, Osorio-Querejeta, Iñaki, Fernández-Nogueira, Patricia, Ferrari, Nicola, Viera, Cristina, Martín-Martín, Natalia, Tzankov, Alexandar, Eppenberger-Castori, Serenella, Alvarez-Lopez, Isabel, Urruticoechea, Ander, Bragado, Paloma, Coleman, Nicholas, Palazón, Asís, Carracedo, Arkaitz, Gallego-Ortega, David, Calvo, Fernando, Isacke, Clare M, Caffarel, María M, Lawrie, Charles H

“…The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the…”
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Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b by Lenza, Maria Pia, Egia-Mendikute, Leire, Antoñana-Vildosola, Asier, Soares, Cátia O., Coelho, Helena, Corzana, Francisco, Bosch, Alexandre, Manisha, Prodhi, Quintana, Jon Imanol, Oyenarte, Iker, Unione, Luca, Moure, María Jesús, Azkargorta, Mikel, Atxabal, Unai, Sobczak, Klaudia, Elortza, Felix, Sutherland, James D., Barrio, Rosa, Marcelo, Filipa, Jiménez-Barbero, Jesús, Palazon, Asis, Ereño-Orbea, June

“…Sialic acid-binding Ig-like lectin 15 (Siglec-15) is an immune modulator and emerging cancer immunotherapy target. However, limited understanding of its…”
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The HIF-1α hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy by Palazón, Asís, Martínez-Forero, Iván, Teijeira, Alvaro, Morales-Kastresana, Aizea, Alfaro, Carlos, Sanmamed, Miguel F, Perez-Gracia, Jose Luis, Peñuelas, Iván, Hervás-Stubbs, Sandra, Rouzaut, Ana, de Landázuri, Manuel Ortiz, Jure-Kunkel, Maria, Aragonés, Julian, Melero, Ignacio

“…The tumor microenvironment of transplanted and spontaneous mouse tumors is profoundly deprived of oxygenation as confirmed by positron emission tomographic…”
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The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent by Goikoetxea-Usandizaga, Naroa, Bravo, Miren, Egia-Mendikute, Leire, Abecia, Leticia, Serrano-Maciá, Marina, Urdinguio, Rocío G, Clos-García, Marc, Rodríguez-Agudo, Rubén, Araujo-Legido, Raquel, López-Bermudo, Lucía, Delgado, Teresa C, Lachiondo-Ortega, Sofía, González-Recio, Irene, Gil-Pitarch, Clàudia, Peña-Cearra, Ainize, Simón, Jorge, Benedé-Ubieto, Raquel, Ariño, Silvia, Herranz, Jose M, Azkargorta, Mikel, Salazar-Bermeo, Julio, Martí, Nuria, Varela-Rey, Marta, Falcón-Pérez, Juan M, Lorenzo, Óscar, Nogueiras, Rubén, Elortza, Félix, Nevzorova, Yulia A, Cubero, Francisco J, Saura, Domingo, Martínez-Cruz, Luis Alfonso, Sabio, Guadalupe, Palazón, Asís, Sancho-Bru, Pau, Elguezabal, Natalia, Fraga, Mario F, Ávila, Matías A, Bataller, Ramón, Marín, José J G, Martín, Franz, Martínez-Chantar, María Luz

“…Alcohol-associated liver disease (ALD) accounts for 70% of liver-related deaths in Europe, with no effective approved therapies. Although mitochondrial…”
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Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment by Araujo, Angela M, Abaurrea, Andrea, Azcoaga, Peio, López-Velazco, Joanna I, Manzano, Sara, Rodriguez, Javier, Rezola, Ricardo, Egia-Mendikute, Leire, Valdés-Mora, Fátima, Flores, Juana M, Jenkins, Liam, Pulido, Laura, Osorio-Querejeta, Iñaki, Fernández-Nogueira, Patricia, Ferrari, Nicola, Viera, Cristina, Martín-Martín, Natalia, Tzankov, Alexandar, Eppenberger-Castori, Serenella, Alvarez-Lopez, Isabel, Urruticoechea, Ander, Bragado, Paloma, Coleman, Nicholas, Palazón, Asís, Carracedo, Arkaitz, Gallego-Ortega, David, Calvo, Fernando, Isacke, Clare M, Caffarel, María M, Lawrie, Charles H

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Agonist Anti-CD137 mAb Act on Tumor Endothelial Cells to Enhance Recruitment of Activated T Lymphocytes by PALAZON, Asis, TEIJEIRA, Alvaro, OCHOA-CALLEJERO, Laura, MARTINEZ, Alfredo, LUQUE, Alfonso, DINCHUK, Joseph, ROUZAUT, Ana, JURE-KUNKEL, Maria, MELERO, Ignacio, MARTINEZ-FORERO, Iván, HERVAS-STUBBS, Sandra, RONCAL, Carmen, PENUELAS, Iván, DUBROT, Juan, MORALES-KASTRESANA, Aizea, PEREZ-GRACIA, Jose Luis, OCHOA, M. Carmen

“…Agonist monoclonal antibodies (mAb) to the immune costimulatory molecule CD137, also known as 4-1BB, are presently in clinical trials for cancer treatment on…”
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Hypoxia Promotes Syndecan-3 Expression in the Tumor Microenvironment by Prieto-Fernández, Endika, Egia-Mendikute, Leire, Bosch, Alexandre, García Del Río, Ana, Jimenez-Lasheras, Borja, Antoñana-Vildosola, Asier, Lee, So Young, Palazon, Asis

“…The syndecan (Sdc) family is comprised of four members of cell surface molecules (Sdc-1 to 4) with different biological functions. Syndecan-3 (Sdc-3) is known…”
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