Search Results - "Palanki, Moorthy S"

Development of novel linkers to conjugate pharmacophores to a carrier antibody by Palanki, Moorthy S.S., Bhat, Abhijit, Lappe, Rodney W., Liu, Bin, Oates, Bryan, Rizzo, John, Stankovic, Nebojsa, Bradshaw, Curt

“…We have developed modified maleimide novel linkers with improved chemical stability that could potentially be used in conjugating various pharmacophores such…”
Get full text

Discovery of 3,3‘-(2,4-Diaminopteridine-6,7-diyl)diphenol as an Isozyme-Selective Inhibitor of PI3K for the Treatment of Ischemia Reperfusion Injury Associated with Myocardial Infarction by Palanki, Moorthy S. S, Dneprovskaia, Elena, Doukas, John, Fine, Richard M, Hood, John, Kang, Xinshan, Lohse, Dan, Martin, Michael, Noronha, Glenn, Soll, Richard M, Wrasidlo, Wolfgang, Yee, Shiyin, Zhu, Hong

“…In studies aimed toward identifying effective and safe inhibitors of kinase signaling cascades that underlie ischemia/reperfusion (I/R) injury, we synthesized…”
Get full text

Development of Prodrug 4-Chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl Benzoate (TG100801): A Topically Administered Therapeutic Candidate in Clinical Trials for the Treatment of Age-Related Macular Degeneration by Palanki, Moorthy S. S, Akiyama, Hideo, Campochiaro, Peter, Cao, Jianguo, Chow, Chun P, Dellamary, Luis, Doukas, John, Fine, Richard, Gritzen, Colleen, Hood, John D, Hu, Steven, Kachi, Shu, Kang, Xinshan, Klebansky, Boris, Kousba, Ahmed, Lohse, Dan, Mak, Chi Ching, Martin, Michael, McPherson, Andrew, Pathak, Ved P, Renick, Joel, Soll, Richard, Umeda, Naoyasu, Yee, Shiyin, Yokoi, Katsutoshi, Zeng, Binqi, Zhu, Hong, Noronha, Glenn

“…Age-related macular degeneration (AMD) is one of the leading causes of loss of vision in the industrialized world. Attenuating the VEGF signal in the eye to…”
Get full text

Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine—a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays by Noronha, Glenn, Barrett, Kathy, Boccia, Antonio, Brodhag, Tessa, Cao, Jianguo, Chow, Chun P., Dneprovskaia, Elena, Doukas, John, Fine, Richard, Gong, Xianchang, Gritzen, Colleen, Gu, Hong, Hanna, Ehab, Hood, John D., Hu, Steven, Kang, Xinshan, Key, Jann, Klebansky, Boris, Kousba, Ahmed, Li, Ge, Lohse, Dan, Mak, Chi Ching, McPherson, Andrew, Palanki, Moorthy S.S., Pathak, Ved P., Renick, Joel, Shi, Feng, Soll, Richard, Splittgerber, Ute, Stoughton, Silva, Tang, Suhan, Yee, Shiyin, Zeng, Binqi, Zhao, Ningning, Zhu, Hong

“…We describe the identification of benzotriazine 3, a potent and orally active Src inhibitor with desirable pharmacokinetic properties and anti-tumor activity…”
Get full text

Development of a long acting human growth hormone analog suitable for once a week dosing by Palanki, Moorthy S.S., Bhat, Abhijit, Bolanos, Ben, Brunel, Florence, Del Rosario, Joselyn, Dettling, Danielle, Horn, Mark, Lappe, Rodney, Preston, Ryan, Sievers, Annette, Stankovic, Nebojsa, Woodnut, Gary, Chen, Gang

“…Human growth hormone was conjugated to a carrier aldolase antibody, using a novel linker by connecting a disulphide bond in growth hormone to a lysine-94 amine…”
Get full text

Discovery and preliminary structure–activity relationship studies of novel benzotriazine based compounds as Src inhibitors by Noronha, Glenn, Barrett, Kathy, Cao, Jianguo, Dneprovskaia, Elena, Fine, Richard, Gong, Xianchang, Gritzen, Colleen, Hood, John, Kang, Xinshan, Klebansky, Boris, Li, G., Liao, W., Lohse, Dan, Mak, Chi Ching, McPherson, Andrew, Palanki, Moorthy S.S., Pathak, Ved P., Renick, Joel, Soll, Richard, Splittgerber, Ute, Wrasidlo, Wolfgang, Zeng, Binqi, Zhao, Ningning, Zhou, Y.

“…We report the SAR studies of a series of structurally novel benzotriazine analogs as inhibitors of Src. The 3-(2-(1-pyrrolidinyl)-ethoxy)phenyl analog ( 43)…”
Get full text

Inhibitors of ABL and the ABL-T315I mutation by Noronha, Glenn, Cao, Jianguo, Chow, Chun P, Dneprovskaia, Elena, Fine, Richard M, Hood, John, Kang, Xinshan, Klebansky, Boris, Lohse, Dan, Mak, Chi Ching, McPherson, Andre, Palanki, Moorthy S S, Pathak, Ved P, Renick, Joel, Soll, Richard, Zeng, Binqi

“…Chronic myelogenous leukemia (CML) is a hematological stem cell disorder caused by increased and unregulated growth of myeloid cells in the bone marrow, and…”
Get more information

Special issue of Medicinal Chemistry Research in honor of Professor Gary L. Grunewald by Palanki, Moorthy S. S., Wolfe, Michael S., Hu, Longqin

Get full text

Inhibitors of AP-1 and NF-kappa B mediated transcriptional activation: therapeutic potential in autoimmune diseases and structural diversity by Palanki, Moorthy S S

“…Cytokines and chemokines play a very important role in a number of inflammatory diseases. In activated T cells, transcription factors such as the activator…”
Get more information

Inhibition of Nuclear Factor-κB in T Cells Suppresses Lung Fibrosis by FUJIMOTO, Hajime, D'ALESSANDRO-GABAZZA, Corina N, SUMIDA, Yasuhiro, ADACHI, Yukihiko, SUZUKI, Koji, TAGUCHI, Osamu, PALANKI, Moorthy S. S, ERDMAN, Paul E, TAKAGI, Takehiro, GABAZZA, Esteban C, BRUNO, Nelson E, YANO, Yutaka, HAYASHI, Tatsuya, TAMAKI, Shigenori

Get full text

The design and preliminary structure–activity relationship studies of benzotriazines as potent inhibitors of Abl and Abl-T315I enzymes by Cao, Jianguo, Fine, Richard, Gritzen, Colleen, Hood, John, Kang, Xinshan, Klebansky, Boris, Lohse, Dan, Mak, Chi Ching, McPherson, Andrew, Noronha, Glenn, Palanki, Moorthy S.S., Pathak, Ved P., Renick, Joel, Soll, Richard, Zeng, Binqi, Zhu, Hong

“…We describe the design, synthesis and structure–activity relationship studies in optimizing a series of benzotriazine compounds as potent inhibitors of both…”
Get full text

Functional analogs of CC-1065 and the duocarmycins incorporating the 9a-(chloromethyl)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (C2BI) alkylation subunit: synthesis and preliminary DNA alkylation studies by Boger, Dale L, Palanki, Moorthy S. S

Get full text

Inhibition of Nuclear Factor-{kappa}B in T Cells Suppresses Lung Fibrosis by Fujimoto, Hajime, D'Alessandro-Gabazza, Corina N, Palanki, Moorthy S. S, Erdman, Paul E, Takagi, Takehiro, Gabazza, Esteban C, Bruno, Nelson E, Yano, Yutaka, Hayashi, Tatsuya, Tamaki, Shigenori, Sumida, Yasuhiro, Adachi, Yukihiko, Suzuki, Koji, Taguchi, Osamu

“…Cytokines secreted by T cells play a pivotal role in the pathogenesis of lung injury and fibrosis, and the transcription factors nuclear factor (NF)-kappaB and…”
Get full text

Inhibitors of NF-κB and AP-1 Gene Expression:  SAR Studies on the Pyrimidine Portion of 2-Chloro-4-trifluoromethylpyrimidine-5-[N-(3‘,5‘-bis(trifluoromethyl)phenyl)carboxamide] by Palanki, Moorthy S. S, Erdman, Paul E, Gayo-Fung, Leah M, Shevlin, Graziella I, Sullivan, Robert W, Goldman, Mark E, Ransone, Lynn J, Bennett, Brydon L, Manning, Anthony M, Suto, Mark J

“…We investigated the structure−activity relationship studies of N-[3,5-bis(trifluoromethyl)phenyl][2-chloro-4-(trifluoromethyl)pyrimidin-5-yl]carboxamide (1),…”
Get full text

2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3‘,5‘-bis(trifluoromethyl)phenyl)- carboxamide:  A Potent Inhibitor of NF-κB- and AP-1-Mediated Gene Expression Identified Using Solution-Phase Combinatorial Chemistry by Sullivan, Robert W, Bigam, Colin G, Erdman, Paul E, Palanki, Moorthy S. S, Anderson, David W, Goldman, Mark E, Ransone, Lynn J, Suto, Mark J

“…Described is the identification of a novel series of compounds that blocks the activation of two key transcription factors, AP-1 and NF-κB. These transcription…”
Get full text

Immunospecific Reduction of Antioligonucleotide Antibody-Forming Cells with a Tetrakis-oligonucleotide Conjugate (LJP 394), a Therapeutic Candidate for the Treatment of Lupus Nephritis by Jones, David S, Barstad, Paul A, Feild, Mark J, Hachmann, John P, Hayag, Merle S, Hill, Kenneth W, Iverson, G. Michael, Livingston, Douglas A, Palanki, Moorthy S

“…A discrete tetravalent conjugate, 7a (LJP 394), consisting of four oligonucleotides attached to a common carrier or platform was prepared. Single-stranded…”
Get full text

The design and synthesis of novel orally active inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. SAR of in vitro and in vivo studies by Palanki, Moorthy S S, Erdman, Paul E, Ren, Minghuan, Suto, Mark, Bennett, Brydon L, Manning, Anthony, Ransone, Lynn, Spooner, Cheryl, Desai, Sonal, Ow, Arnie, Totsuka, Ryuichi, Tsao, Peter, Toriumi, Wataru

“…We have developed novel orally active quinazoline analogues as inhibitors of AP-1 and NF-kappaB mediated transcriptional activation. Among the derivatives…”
Get full text

Structure-activity relationship studies of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate: an inhibitor of AP-1 and NF-kappaB mediated gene expression by Palanki, Moorthy S S, Gayo-Fung, Leah M, Shevlin, Graziella I, Erdman, Paul, Sato, Mark, Goldman, Mark, Ransone, Lynn J, Spooner, Cheryl

“…Several analogues of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate (1) were synthesized and tested as…”
Get full text

The design and synthesis of novel orally active inhibitors of AP-1 and NF-KB mediated transcriptional activation. SAR of in vitro and in vivo studies by PALANKI, Moorthy S. S, ERDMAN, Paul E, TOTSUKA, Ryuichi, TSAO, Peter, TORIUMI, Wataru, MINGHUAN REN, SUTO, Mark, BENNETT, Brydon L, MANNING, Anthony, RANSONE, Lynn, SPOONER, Cheryl, DESAI, Sonal, OW, Arnie

Get full text

Structure-activity relationship studies of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carb oxylate: An inhibitor of AP-1 and NF-kB mediated gene expression by PALANKI, Moorthy S. S, GAYO-FUNG, Leah M, SHEVLIN, Graziella I, ERDMAN, Paul, SATO, Mark, GOLDMAN, Mark, RANSONE, Lynn J, SPOONER, Cheryl

Get full text