Search Results - "Palaniyappan, Lena"

Dysregulated Brain Dynamics in a Triple-Network Saliency Model of Schizophrenia and Its Relation to Psychosis by Supekar, Kaustubh, Cai, Weidong, Krishnadas, Rajeev, Palaniyappan, Lena, Menon, Vinod

“…Schizophrenia is a highly disabling psychiatric disorder characterized by a range of positive “psychosis” symptoms. However, the neurobiology of psychosis and…”
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Early treatment response in first episode psychosis: a 7-T magnetic resonance spectroscopic study of glutathione and glutamate by Dempster, Kara, Jeon, Peter, MacKinley, Michael, Williamson, Peter, Théberge, Jean, Palaniyappan, Lena

“…Early response to antipsychotic medications is one of the most important determinants of later symptomatic and functional outcomes in psychosis. Glutathione…”
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Subcortical Origin of Salience Processing Deficits in Schizophrenia by Palaniyappan, Lena

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Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction by Palaniyappan, Lena, MBBS, MMedSci, Liddle, Peter F., BMBCh, PhD

“…The insular cortex is one of the brain regions that show consistent abnormalities in both structural and functional neuroimaging studies of schizophrenia. In…”
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Glutathione and glutamate in schizophrenia: a 7T MRS study by Kumar, Jyothika, Liddle, Elizabeth B., Fernandes, Carolina C., Palaniyappan, Lena, Hall, Emma L., Robson, Siân E., Simmonite, Molly, Fiesal, Jan, Katshu, Mohammad Z., Qureshi, Ayaz, Skelton, Michael, Christodoulou, Nikolaos G., Brookes, Matthew J., Morris, Peter G., Liddle, Peter F.

“…In schizophrenia, abnormal neural metabolite concentrations may arise from cortical damage following neuroinflammatory processes implicated in acute episodes…”
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The trajectory of putative astroglial dysfunction in first episode schizophrenia: a longitudinal 7-Tesla MRS study by Jeon, Peter, Mackinley, Michael, Théberge, Jean, Palaniyappan, Lena

“…Myo-inositol is mainly found in astroglia and its levels has been shown to be reduced in the anterior cingulate cortex (ACC) of patients with schizophrenia. We…”
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Diagnostic Discontinuity in Psychosis: A Combined Study of Cortical Gyrification and Functional Connectivity by PALANIYAPPAN, Lena, LIDDLE, Peter F

“…The point of rarity in brain structure and function that separates the 2 major psychotic disorders--schizophrenia and bipolar disorder--is presently unknown…”
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Glutamate and Dysconnection in the Salience Network: Neurochemical, Effective Connectivity, and Computational Evidence in Schizophrenia by Limongi, Roberto, Jeon, Peter, Mackinley, Michael, Das, Tushar, Dempster, Kara, Théberge, Jean, Bartha, Robert, Wong, Dickson, Palaniyappan, Lena

“…Functional dysconnection in schizophrenia is underwritten by a pathophysiology of the glutamate neurotransmission that affects the excitation-inhibition…”
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Differential effects of surface area, gyrification and cortical thickness on voxel based morphometric deficits in schizophrenia by Palaniyappan, Lena, Liddle, Peter F.

“…Voxel Based Morphometry (VBM) and Surface Based Morphometry (SBM) are the two most commonly used methods to study the structure of gray matter in various…”
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Neuroimaging the consciousness of self: Review, and conceptual-methodological framework by Frewen, Paul, Schroeter, Matthias L., Riva, Giuseppe, Cipresso, Pietro, Fairfield, Beth, Padulo, Caterina, Kemp, Andrew Haddon, Palaniyappan, Lena, Owolabi, Mayowa, Kusi-Mensah, Kwabena, Polyakova, Maryna, Fehertoi, Nick, D’Andrea, Wendy, Lowe, Leroy, Northoff, Georg

“…•Neuroimaging studies of Self-Referential Processing (SRP) are reviewed.•Verbal (introspective, semantic) SRP is compared with Non-Verbal SRP (interoceptive,…”
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Aberrant cortical gyrification in schizophrenia: a surface-based morphometry study by Palaniyappan, Lena, MBBS, Liddle, Peter F., BMBCh, PhD

“…Background Schizophrenia is considered to be a disorder of cerebral connectivity associated with disturbances of cortical development. Disturbances in…”
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The centrality of working memory networks in differentiating bipolar type I depression from unipolar depression: A task-fMRI study by Xi, Chang, Liu, Zhening, Zeng, Can, Tan, Wenjian, Sun, Fuping, Yang, Jie, Palaniyappan, Lena

“…Objectives Up to 70%–80% of patients with bipolar disorder are misdiagnosed as having major depressive disorder (MDD), leading to both delayed intervention and…”
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Resolving heterogeneity in schizophrenia through a novel systems approach to brain structure: individualized structural covariance network analysis by Liu, Zhaowen, Palaniyappan, Lena, Wu, Xinran, Zhang, Kai, Du, Jiangnan, Zhao, Qi, Xie, Chao, Tang, Yingying, Su, Wenjun, Wei, Yarui, Xue, Kangkang, Han, Shaoqiang, Tsai, Shih-Jen, Lin, Ching-Po, Cheng, Jingliang, Li, Chunbo, Wang, Jijun, Sahakian, Barbara J., Robbins, Trevor W., Zhang, Jie, Feng, Jianfeng

“…Reliable mapping of system-level individual differences is a critical first step toward precision medicine for complex disorders such as schizophrenia…”
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Neural Primacy of the Salience Processing System in Schizophrenia by Palaniyappan, Lena, Simmonite, Molly, White, Thomas P., Liddle, Elizabeth B., Liddle, Peter F.

“…For effective information processing, two large-scale distributed neural networks appear to be critical: a multimodal executive system anchored on the…”
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Neurovascular Uncoupling in Schizophrenia: A Bimodal Meta-Analysis of Brain Perfusion and Glucose Metabolism by Sukumar, Niron, Sabesan, Priyadharshini, Anazodo, Udunna, Palaniyappan, Lena

“…The use of modern neuroimaging approaches has demonstrated resting-state regional cerebral blood flow (rCBF) to be tightly coupled to resting cerebral glucose…”
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Abnormal hemispheric asymmetry of both brain function and structure in attention deficit/hyperactivity disorder: a meta-analysis of individual participant data by He, Ningning, Palaniyappan, Lena, Linli, Zeqiang, Guo, Shuixia

“…Aberration in the asymmetric nature of the human brain is associated with several mental disorders, including attention deficit/hyperactivity disorder (ADHD)…”
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Oxytocin modulates the effective connectivity between the precuneus and the dorsolateral prefrontal cortex by Kumar, Jyothika, Iwabuchi, Sarina J., Völlm, Birgit A., Palaniyappan, Lena

“…Our social activity is heavily influenced by the process of introspection, with emerging research suggesting a role for the Default Mode Network (DMN) in…”
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Brain-Wide Functional Dysconnectivity in Schizophrenia: Parsing Diathesis, Resilience, and the Effects of Clinical Expression by Guo, Shuixia, He, Ningning, Liu, Zhening, Linli, Zeqiang, Tao, Haojuan, Palaniyappan, Lena

“…Background: The functional dysconnectivity observed from functional magnetic resonance imaging (fMRI) studies in schizophrenia is also seen in unaffected…”
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Antioxidant defense in schizophrenia and bipolar disorder: A meta-analysis of MRS studies of anterior cingulate glutathione by Das, Tushar Kanti, Javadzadeh, Alborz, Dey, Avyarthana, Sabesan, Priyadharshini, Théberge, Jean, Radua, Joaquim, Palaniyappan, Lena

“…Glutathione [GSH] is a major intracellular antioxidant that disposes peroxides and protects neurons and glial cells from oxidative stress. In both…”
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Repetitive transcranial magnetic stimulation versus electroconvulsive therapy for major depression: A systematic review and meta-analysis by Ren, Juanjuan, Li, Hui, Palaniyappan, Lena, Liu, Hongmei, Wang, Jijun, Li, Chunbo, Rossini, Paolo Maria

“…Electroconvulsive therapy (ECT) is the most effective treatment of depression. During the last decades repetitive transcranial magnetic stimulation (rTMS), an…”
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