Role of cytokines and reactive oxygen species in brain aging

Role of cytokines and reactive oxygen species in brain aging

Aging is a complex process that produces profound effects on the brain. Although a number of external factors can promote the initiation and progression of brain aging, peripheral and central changes in the immune cells with time, also play an important role. Immunosenescence, which is an age-associ...

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Bibliographic Details
Published in:Mechanisms of ageing and development Vol. 214; p. 111855
Main Authors: MohanKumar, Sheba M.J., Murugan, Abarna, Palaniyappan, Arunkumar, MohanKumar, Puliyur S.
Format: Journal Article
Language:English
Published: Ireland Elsevier B.V 01-09-2023
Subjects:
Brain
Cytokines
Depression
Humans
Immunosenescence
Inflammaging
Inflammation
Neurodegeneration
Neurotransmitters
Reactive Oxygen Species
Reactive oxygen species
Neurotransmitters
Cytokines
Neurodegeneration
Inflammaging
Immunosenescence
Depression
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Summary:Aging is a complex process that produces profound effects on the brain. Although a number of external factors can promote the initiation and progression of brain aging, peripheral and central changes in the immune cells with time, also play an important role. Immunosenescence, which is an age-associated decline in immune function and Inflammaging, a low-grade inflammatory state in the aging brain contribute to an elevation in cytokine and reactive oxygen species production. In this review, we focus on the pro-inflammatory state that is established in the brain as a consequence of these two phenomena and the resulting detrimental changes in brain structure, function and repair that lead to a decline in central and neuroendocrine function. •Aging is a complicated biological process that is induced by changes in the immune system (immunosenescence).•Immunosenescence causes inflammaging by promoting the establishment of a pro-inflammatory state.•Consequently, there is an increase in ROS generation which further triggers cytokine production leading to a vicious cycle.•The resultant changes in proteins, lipids and DNA compromise the brain’s capacity for regeneration and repair.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0047-6374
1872-6216
1872-6216
DOI:10.1016/j.mad.2023.111855